RESUMO
The article presents the results of urological examination (spermograms and data of ultrasound examination) of 22 patients with chronic brucellosis and diseases of the scrotum (6 patients with orchitis, 16 with orchiepididymitis) before and after conventional therapy (10 patients) and combined treatment with the inclusion of cycloferon (2 courses of 5 intramuscular injection [0.25 g] with an interval of 10 days)--12 patients. It is shown that the administration of cycloferon leads to more effective relief of intoxication symptoms and inflammation in the testes and appendages (reduction of scrotal wall thickness, size of testes and/or adjuncts, and the incidence and severity of hydrocele), and has a positive effect on spermatogenesis (reduction of semen viscosity, the number of white blood cells in semen, sperm agglutination associated with the formation of sperm antibodies in most patients after treatment), as well as reduces the number of exacerbations of chronic orchitis/orchiepididymitis by 2.4 times.
Assuntos
Acridinas/administração & dosagem , Brucelose , Indutores de Interferon/administração & dosagem , Orquite , Escroto , Testículo , Adulto , Brucelose/tratamento farmacológico , Brucelose/patologia , Brucelose/fisiopatologia , Humanos , Masculino , Orquite/tratamento farmacológico , Orquite/patologia , Orquite/fisiopatologia , Recuperação de Função Fisiológica/efeitos dos fármacos , Escroto/patologia , Escroto/fisiopatologia , Espermatogênese/efeitos dos fármacos , Testículo/patologia , Testículo/fisiopatologiaRESUMO
Clinical and pathogenetic efficacy of cytoflavin as a component of combined therapy of chronic brucellosis was tested in 50 patients who repeated its beneficial effect on the quality of life. The mechanism of cytoflavin action consists of lowering severity of endogenous intoxication and systemic inflammation.
Assuntos
Brucelose/tratamento farmacológico , Mononucleotídeo de Flavina/uso terapêutico , Inosina Difosfato/uso terapêutico , Niacinamida/uso terapêutico , Succinatos/uso terapêutico , Adulto , Doença Crônica , Combinação de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
Patients with chronic brucellosis underwent a complex clinical and laboratory studies to determine the indicators reflecting the degree of systemic inflammation and endotoxicosis. On the basis of an analysis of the findings, an integral quantitative approach was applied to describing the associations between various pathophysiological processes and clinical manifestations; criteria for the activity of the infectious process were objectivized, and the form of chronic brucellosis was defined. The mathematical simulation method was shown to be an adequate tool to objectivized the differential diagnosis of the clinical forms of the disease.