Detalhe da pesquisa
1.
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.
Proc Natl Acad Sci U S A
; 105(33): 11915-20, 2008 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18695239
2.
Measurement of lipogenic flux by deuterium resolved mass spectrometry.
Nat Commun
; 12(1): 3756, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145255
3.
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.
J Clin Invest
; 116(11): 2995-3005, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17080197
4.
Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.
Elife
; 62017 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28244871
5.
Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Cell Metab
; 26(2): 394-406.e6, 2017 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28768177
6.
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
Nat Med
; 21(11): 1280-9, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26437365
7.
Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Cell Metab
; 26(3): 576, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28877461
8.
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.
Proc Natl Acad Sci U S A
; 102(15): 5374-9, 2005 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15805190
9.
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
Proc Natl Acad Sci U S A
; 100(21): 12027-32, 2003 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-14512514