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In this work, Eu2O3-doped (CaCu3Ti4O12)x of low dielectric loss have been fabricated using both conventional (CS) and microwave sintering (MWS), where x = Eu2O3 = 0.1, 0.2, and 0.3, respectively. According to X-ray diffraction (XRD) and scanning electron microscope (SEM) reports, increasing the concentration of Eu3+ in the CCTO lattice causes the grain size of the MWS samples to increase and vice versa for CS. The X-ray photoelectron spectroscopy (XPS) delineated the binding energies and charge states of the Cu2+/Cu+ and Ti4+/Ti3+ transition ions. Energy dispersive spectroscopy (EDS) analysis revealed no Cu-rich phase along the grain boundaries that directly impacts the dielectric properties. The dielectric characteristics, which include dielectric constant (ε) and the loss (tan δ), were examined using broadband dielectric spectrometer (BDS) from 10 to 107 Hz at ambient temperature. The dielectric constant was >104 and >102 for CS and MWS samples at x > 0.1, respectively, with the low loss being constant even at high frequencies due to the effective suppression of tan δ by Eu3+. This ceramic of low dielectric loss has potential for commercial applications at comparatively high frequencies.
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Európio , Micro-Ondas , Cerâmica , Grão Comestível , Espectroscopia FotoeletrônicaRESUMO
In this research, we intended to examine the effect of heating mode on the densification, microstructure, mechanical properties, and corrosion resistance of sintered aluminum alloys. The compacts were sintered in conventional (radiation-heated) and microwave (2.45 GHz, multimode) sintering furnaces followed by aging. Detailed analysis of the final sintered aluminum alloys was done using optical and scanning electron microscopes. The observations revealed that the microwave sintered sample has a relatively finer microstructure compared to its conventionally sintered counterparts. The experimental results also show that microwave sintered alloy has the best mechanical properties over conventionally sintered compacts. Similarly, the microwave sintered samples showed better corrosion resistance than conventionally sintered ones.
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The effect of molybdenum additions on the phases, microstructures, and mechanical properties of pre-alloyed Ti6Al4V was studied through the spark plasma sintering technique. Ti6Al4V-xMo (where x = 0, 2, 4, 6 wt.% of Mo) alloys were developed, and the sintered compacts were characterized in terms of their phase composition, microstructure, and mechanical properties. The results show that the equiaxed primary alpha and Widmänstatten (alpha + beta) microstructure in pre-alloyed Ti6Al4V is transformed into a duplex and globular model with the increasing content of Mo from 0 to 6%. The changing pattern of the microstructure of the sample strongly influences the properties of the material. The solid solution hardening element such as Mo enhances mechanical properties such as yield strength, ultimate tensile strength, ductility, and hardness compared with the pre-alloyed Ti6Al4V alloy.
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The plantaris muscle (PM) typically begins with a short, fusiform muscle belly and continues as a slim tendon traversing distally between the gastrocnemius and soleus to attach into the calcaneus directly or Achilles tendon. Conventionally, it has been of most interest as a donor for surgeons plantaris tendon (PT) grafting and recent studies have implicated the PT in the development of Achilles tendinopathy. During routine cadaveric dissection, one such anatomical variation was identified in a cadaver with two distal tendons of the PM and also multiple tendon connections into the crural fascia. While similar variants have been reported before in isolation, to our knowledge, this has been rarely reported illustrating the coexistence of a duplicated PT with simultaneous fascial connections into the crural fascia. The clinical implications of such a finding are discussed.
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Tendão do Calcâneo , Tendinopatia , Variação Anatômica , Fáscia , Humanos , Músculo EsqueléticoRESUMO
Staphylococcus aureus an opportunistic pathogen, causes biofilm-associated infections like nosocomial and chronic disease, where quorum sensing plays vital role. Biofilm-associated infections are provocative due to antibiotic resistance and become major public health threat to human. Accordingly, there is an urgent need to identify novel compounds and groundbreaking methods to pervade and clear biofilm-associated infections. It has been suggested that naturally occurring small molecules especially flavonoids could be used as a new source of anti-biofilm drugs. Thus, an attempt to evaluate the effectiveness of Morin against Staphylococcus aureus resistant strains, through in-vitro (antibacterial, anti-biofilm, microscopic analysis, anti-motility, anti-spreading, cell viability and EPS production assay) and in-silico studies (Docking and Molecular dynamic simulation). Interestingly, in vitro and microscopic analysis revealed Morin to have very less or negligible antibiotic activity against methicillin resistant and vancomycin resistant Staphylococcus aureus, however, Morin exhibited significant biofilm inhibition, reduced motility and spreading, and EPS production of both the resistant strains. Further, studies on the molecular interaction of Morin with global regulatory protein (SarA) of Staphylococcus aureus, suggested the effective role of Morin as an anti-quorum sensing agent and interpolating the further studies to suit it as drug candidate against the pathogenic bacteria.
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Antibacterianos/metabolismo , Biofilmes/efeitos dos fármacos , Flavonoides/metabolismo , Percepção de Quorum/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Proteínas de Bactérias/química , Proteínas de Bactérias/metabolismo , Metabolismo dos Carboidratos/efeitos dos fármacos , Humanos , Locomoção/efeitos dos fármacos , Simulação de Acoplamento Molecular , Ligação Proteica , Staphylococcus aureus/fisiologiaRESUMO
Nanomaterials show great opportunities in the development of electronics, biosensors, chemical and industrial applications. In this article, we are reporting the cytotoxicity and antibacterial characteristics of graphene-oxide (GO) nanosheets toward selected human pathogens. GO is prepared by using modified Hummers method. The prepared GO is characterized using X-ray diffraction, Raman analysis and transmission electron microscopy. Our studies confirmed the antimicrobial activity of GO against various human pathogens. The cytotoxicity effects of GO nanosheets are investigated using MTT assay which confirms that GO nanosheets are non-toxic and eco-friendly. These results ensure that GO nanosheets can be a potential antibacterial agent in the biological, health related industry development and applications.
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Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Grafite/toxicidade , Nanoestruturas , Grafite/química , Humanos , Microscopia Eletrônica de Varredura , Microscopia Eletrônica de Transmissão , Óxidos/química , Espectrofotometria Ultravioleta , Análise Espectral Raman , Difração de Raios XRESUMO
The temperature effect on the wear behaviour of EV31A Mg alloy during dry sliding wear was investigated. Wear tests were carried out at 50, 100, 150, 200, and 250 °C using a standard load of 10 N and a sliding distance of 1000 m. Weight loss method was used to calculate the wear rate. Optical microscopy was used to examine the microstructure of the EV31A alloy. FE-SEM with EDS analysis was used to investigate the wear morphology, and XRD analysis was performed both before and after the wear test. A high wear coefficient (K) value (more than 10-4) indicates extreme wear for EV31A in all the scenarios. T4 EV31A had a maximum wear rate of 20.2 mg at 150 °C. The as-cast EV31A alloy exhibits an excellent wear rate at the price of mechanical properties under all test scenarios. Wear resistance is improved by Nd and Zr oxides, although Mg and Gd oxides have little effect. Zn has no effect on the wear behaviour of the EV31A. In as-cast, T4, and T6 heat-treated conditions, the EV31A alloy exhibits delamination (abrasive wear), oxide development (corrosive wear), and delamination mixed with plastic deformation (adhesive wear). A Three-layered ANN and adapted Fine Gaussian SVM predicted tribological characteristics. In ANN prediction, the maximum R2 was 0.99 for CoF and 0.89 for wear rate, respectively. Despite the fact that the study's normal load is constant, machine learning models allow to deduce that temperature and normal load are the main influential parameters in CoF and wear rate, respectively.
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Scientists are drawn to the new green composites because they may demonstrate qualities that are comparable to those of composites made of synthetic fibers due to concerns about environmental contamination. In this work, the potential for using the produced green composite in different buckling load-bearing structural applications is explored. The work on composite buckling characteristics is vital because one needs to know the composite's structural stability since buckling leads to structural instability. The buckling properties of composite specimens with epoxy as the matrix and chemically treated cellulose microfibrils as reinforcements are examined numerically in this study when exposed to axial compressive stress. The numerical model is first created based on the finite element method model. Its validity is checked using ANSYS software by contrasting the critical buckling loads determined through research for three samples. The numerical findings acquired using the finite element method are then contrasted with those produced using the regression equation derived from the ANOVA. The utilization of the created green composite in different buckling load-bearing structural applications is investigated in this study. As a result of the green composite's unaltered buckling properties compared to synthetic composites, it has the potential to replace numerous synthetic composites, improving environmental sustainability.
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Pituitary carcinoma occurs in ~0.2% of resected pituitary tumours and carries a poor prognosis (mean survival <4 years), with standard chemotherapy regimens showing limited efficacy. Recent evidence suggests that temozolomide (TMZ), an orally-active alkylating agent used principally in the management of glioblastoma, may also be effective in controlling aggressive/invasive pituitary adenomas/carcinomas. A low level of expression of the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) predicts TMZ responsiveness in glioblastomas, and a similar correlation has been observed in the majority of aggressive pituitary adenomas/carcinomas reported to date. Here, we report a case of a silent pituitary corticotroph adenoma, which subsequently re-presented with Cushing's syndrome due to functioning hepatic metastases. The tumour exhibited low immunohistochemical MGMT expression in both primary (pituitary) and secondary (hepatic) lesions. Initial TMZ therapy (200 mg/m² for 5 days every 28 days-seven cycles) resulted in marked clinical, biochemical [>50% fall in adrenocorticotrophic hormone (ACTH)] and radiological [partial RECIST (response evaluation criteria in solid tumors) response] improvements. The patient then underwent bilateral adrenalectomy. However, despite reintroduction of TMZ therapy (further eight cycles) ACTH levels plateaued and no further radiological regression was observed. We review the existing literature reporting TMZ efficacy in pituitary corticotroph tumours, and highlight the pointers/lessons for treating aggressive pituitary neoplasia that can be drawn from experience of susceptibility and evolving resistance to TMZ therapy in glioblastoma. Possible strategies for mitigating resistance developing during TMZ treatment of pituitary adenomas/carcinomas are also considered.
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Dacarbazina/análogos & derivados , Neoplasias Hipofisárias/tratamento farmacológico , Adenoma Hipofisário Secretor de ACT/tratamento farmacológico , Adenoma Hipofisário Secretor de ACT/patologia , Adenoma/tratamento farmacológico , Idoso , Antineoplásicos Alquilantes/uso terapêutico , Dacarbazina/uso terapêutico , Resistencia a Medicamentos Antineoplásicos , Glioblastoma/tratamento farmacológico , Humanos , Neoplasias Hepáticas/secundário , Masculino , O(6)-Metilguanina-DNA Metiltransferase/metabolismo , Neoplasias Hipofisárias/patologia , Neoplasias Hipofisárias/cirurgia , TemozolomidaRESUMO
Calcium Copper Titanium Oxide (CaCu3Ti4O12/CCTO) has grasped massive attention for its colossal dielectric constant in high operating frequencies and wide temperature range. However, the synthesis and processing of CCTO directly influence the material's properties, imparting the overall performance. Researchers have extensively probed into these downsides, but the need for a new and novel approach has been in high demand. Modern synthesis routes and advanced non-conventional sintering techniques have been employed to curb the drawbacks for better properties and performance. This review provides a short overview of the modern synthesis and sintering methods that utilize direct pulse current and electromagnetic waves to improve the material's electrical, optical, and dielectric properties in the best ways possible. In addition, the current application of CCTO as a photocatalyst under visible light and CuO's role in the efficient degradation of pollutants in replacement for other metal oxides has been reviewed. This research also provides a brief overview of using CCTO as a photoelectrode in zinc-air batteries (ZAB) to improve the Oxidation-reduction and evolution (ORR/OER) reactions.
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This review paper gives an insight into the microstructural, mechanical, biological, and corrosion resistance of spark plasma sintered magnesium (Mg) composites. Mg has a mechanical property similar to natural human bones as well as biodegradable and biocompatible properties. Furthermore, Mg is considered a potential material for structural and biomedical applications. However, its high affinity toward oxygen leads to oxidation of the material. Various researchers optimize the material composition, processing techniques, and surface modifications to overcome this issue. In this review, effort has been made to explore the role of process techniques, especially applying a typical powder metallurgy process and the sintering technique called spark plasma sintering (SPS) in the processing of Mg composites. The effect of reinforcement material on Mg composites is illustrated well. The reinforcement's homogeneity, size, and shape affect the mechanical properties of Mg composites. The evidence shows that Mg composites exhibit better corrosion resistance, as the reinforcement act as a cathode in a Mg matrix. However, in most cases, a localized corrosion phenomenon is observed. The Mg composite's high corrosion rate has adversely affected cell viability and promotes cytotoxicity. The reinforcement of bioactive material to the Mg matrix is a potential method to enhance the corrosion resistance and biocompatibility of the materials. However, the impact of SPS process parameters on the final quality of the Mg composite needs to be explored.
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The most well-known and widely used non-traditional manufacturing method is electrical discharge machining (EDM). It is well-known for its ability to cut rigid materials and high-temperature alloys that are difficult to machine with traditional methods. The significant challenges encountered in EDM are high tool wear rate, low material removal rate, and high surface roughness caused by the continuous electric spark generated between the tool and the workpiece. Researchers have reported using a variety of approaches to overcome this challenge, such as combining the die-sinking EDM process with cryogenic treatment, cryogenic cooling, powder-mixed processing, ultrasonic assistance, and other methods. This paper examines the results of these association techniques on various performance measures, such as material removal rate (MRR), tool wear rate (TWR), surface roughness, surface integrity, and recast layer formed during machining, and identifies potential gap areas and proposes a solution. The manuscript is useful for improving performance and introducing new resolutions to the field of EDM machining.
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The present study examines the effect of heating mode on the densification, microstructure, and mechanical properties of iron-nickel steel with graphite and phosphorus addition. The compacts were sintered in conventional (radiatively-heated) and microwave (2.45 GHz, multimode) furnaces at 1120 degrees C for 1 hour in forming gas (dissociated ammonia atmosphere, 95% N2-5% H2). The experimental results show that microwave sintered alloy has better properties compared with the conventionally sintered counterparts. Detailed analyses by using optical microscopy and scanning electron microscopy (SEM) reveal that microwave sintered sample has finer microstructure. SEM examination of the fractured surfaces indicate that a mixed mode fracture containing both, ductile and brittle types, is present in microwave sintered alloy, in contrast with the brittle fracture only in conventional sintered counterpart.
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Calefação/métodos , Ferro/química , Micro-Ondas , Níquel/química , Aço/química , Dureza , Ferro/efeitos da radiação , Teste de Materiais , Níquel/efeitos da radiação , Tamanho da Partícula , Aço/efeitos da radiaçãoRESUMO
There is a massive demand for low-weight high strength materials in automotive, space aerospace, and even structural industries in this present engineering world. These industries attract composites only because of their high strength, resistance to wear, and low weight. Among these composites, metal matrix composite finds wide applications due to its elevated properties, excellent resistance property, corrosion resistance, etc. The reinforcements exist in particles, fiber, and whiskers. Among the three, particles play an important role because of their availability and wettability with the metal matrix. Additionally, among the various metal matrices such as aluminum, magnesium, copper, titanium, etc., aluminum plays a vital role among metal matrices because of its cost, availability in abundance, and castability. Stir casting is the most inexpensive and straightforward composite fabrication technique among the prevailing techniques. Even though so many factors contribute to the elevated property of composites, metal matrix, and reinforcement phase, uniform distribution and wettability are essential factors among all the other factors. This review aims to develop a composite with elevated property in a cost-effective manner. Cost includes metal matrix, reinforcement, and processing technique. Various works have been tabulated to achieve the above objective, and analysis was carried out on tensile strength concerning microstructure. This review paper explores the challenges in composite fabrication and finds a solution to overcome them.
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In the present work, nano Cu (0, 5, 10, 15, 20, 25 wt.%) was added to W, and W-Cu composites were fabricated using the spark plasma sintering (S.P.S.) technique. The densification, microstructural evolution, tensile strength, micro-hardness, and electrical conductivity of the W-Cu composite samples were evaluated. It was observed that increasing the copper content resulted in increasing the relative sintered density, with the highest being 82.26% in the W75% + Cu25% composite. The XRD phase analysis indicated that there was no evidence of intermetallic phases. The highest ultimate (tensile) strength, micro-hardness, and electrical conductivity obtained was 415 MPa, 341.44 HV0.1, and 28.2% IACS, respectively, for a sample containing 25 wt.% nano-copper. Fractography of the tensile tested samples revealed a mixed-mode of fracture. As anticipated, increasing the nano-copper content in the samples resulted in increased electrical conductivity.
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The evolution of a sustainable green composite in various loadbearing structural applications tends to reduce pollution, which in turn enhances environmental sustainability. This work is an attempt to promote a sustainable green composite in buckling loadbearing structural applications. In order to use the green composite in various structural applications, the knowledge on its structural stability is a must. As the structural instability leads to the buckling of the composite structure when it is under an axial compressive load, the work on its buckling characteristics is important. In this work, the buckling characteristics of a woven flax/bio epoxy (WFBE) laminated composite plate are investigated experimentally and numerically when subjected to an axial compressive load. In order to accomplish the optimization study on the buckling characteristics of the composite plate among various structural criterions such as number of layers, the width of the plate and the ply orientation, the optimization tool "response surface methodology" (RSM) is used in this work. The validation of the developed finite element model in Analysis System (ANSYS) version 16 is carried out by comparing the critical buckling loads obtained from the experimental test and numerical simulation for three out of twenty samples. A comparison is then made between the numerical results obtained through ANSYS16 and the results generated using the regression equation. It is concluded that the buckling strength of the composite escalates with the number of layers, the change in width and the ply orientation. It is also noted that the weaving model of the fabric powers the buckling behavior of the composite. This work explores the feasibility of the use of the developed green composite in various buckling loadbearing structural applications. Due to the compromised buckling characteristics of the green composite with the synthetic composite, it has the capability of replacing many synthetic composites, which in turn enhances the sustainability of the environment.
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The effect of adding molybdenum to the heavy tungsten alloy of W-Ni-Fe on its material characteristics was examined in the current study. The elemental powders of tungsten, iron, nickel, and molybdenum, with a composition analogous to W-3Fe-7Ni-xMo (x = 0, 22.5, 45, 67.5 wt.%), were fabricated using the spark plasma sintering (SPS) technique at a sintering temperature of 1400 °C and under pressure of 50 MPa. The sintered samples were subjected to microstructural characterization and tested for mechanical strength. The smallest grain size of 9.99 microns was observed for the 45W-45Mo alloy. This alloy also gave the highest tensile and yield strengths of 1140 MPa and 763 MPa, respectively. The hardness increased with the increased addition of molybdenum. The high level of hardness was observed for 67.5Mo with a 10.8% increase in the base alloy's hardness. The investigation resulted in the alloy of 45W-7Ni-3Fe-45Mo, observed to provide optimum mechanical properties among all the analyzed samples.
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Due to the growing environmental awareness, the development of sustainable green composites is in high demand in composite industries, mainly in the automotive, aircraft, construction and marine applications. This work was an attempt to experimentally and numerically investigate the dynamic characteristics of Woven Flax/Bio epoxy laminated composite plates. In addition, the optimisation study on the dynamic behaviours of the Woven Flax/Bio epoxy composite plate is carried out using the response surface methodology (RSM) by consideration of the various parameters like ply orientation, boundary condition and aspect ratio. The elastic constants of the Woven Flax/Bio epoxy composite lamina needed for the numerical simulation are determined experimentally using two methods, i.e., the usual mechanical tests as well as through the impulse excitation of vibration-based approach and made a comparison between them. The numerical analysis on the free vibration characteristics of the composite was carried out using ANSYS, a finite element analysis (FEA) software. The confirmation of the FE model was accomplished by comparing the numerical results with its experimental counterpart. Finally, a comparison was made between the results obtained through the regression equation and finite element analysis.
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The traditional solid-state reaction method was employed to synthesize bulk calcium cobaltite (Ca349/Ca3Co4O9) ceramics via ball milling the precursor mixture. The samples were compacted using conventional sintering (CS) and spark plasma sintering (SPS) at 850, 900, and 950 °C. The X-ray diffraction (XRD) pattern indicates the presence of the Ca349 phase for samples sintered at 850 and 900 °C. In addition, SPS fosters higher densification (81.18%) than conventional sintering (50.76%) at elevated sintering temperatures. The thermo-gravimetric analysis (TGA) and differential thermal analysis (DTA) performed on the precursor mixture reported a weight loss of ~25.23% at a temperature range of 600-820 °C. This current work aims to analyze the electrical properties (Seebeck coefficient (s), electrical resistivity (ρ), and power factor) of sintered samples as a function of temperature (35-500 °C). It demonstrates that the change in sintering temperature (conventional sintering) did not evince any significant change in the Seebeck coefficient (113-142 µV/K). However, it reported a low resistivity of 153-132 µΩ-m and a better power factor (82-146.4 µW/mK2) at 900 °C. On the contrary, the SPS sintered samples recorded a higher Seebeck coefficient of 121-181 µV/K at 900 °C. Correspondingly, the samples sintered at 950 °C delineated a low resistivity of 145-158 µΩ-m and a better power factor (97-152 µW/mK2).