Detalhe da pesquisa
1.
Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg Med Chem Lett
; 90: 129331, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37187252
2.
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
Bioorg Med Chem Lett
; 29(19): 126610, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471167
3.
Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
Bioorg Med Chem Lett
; 29(3): 509-514, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30553738
4.
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Bioorg Med Chem Lett
; 28(19): 3168-3173, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30174152
5.
Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.
Antimicrob Agents Chemother
; 60(3): 1464-75, 2015 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26711771
6.
Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1.
Antimicrob Agents Chemother
; 58(10): 6032-43, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25070106
7.
Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Bioorg Med Chem Lett
; 23(10): 3064-9, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23570789
8.
Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues.
Bioorg Med Chem Lett
; 23(21): 6019-24, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24035097
9.
Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7.
Bioorg Med Chem Lett
; 18(19): 5294-8, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18774709
10.
Inhibition of papillomavirus protein function in cervical cancer cells by intrabody targeting.
J Mol Biol
; 355(3): 360-78, 2006 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16324714
11.
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Nat Commun
; 8(1): 430, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28874661
12.
Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
J Med Chem
; 57(8): 3570-87, 2014 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24689770
13.
Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.
J Med Chem
; 55(7): 3578-82, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22439843
14.
Monocyclic ß-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.
ACS Chem Biol
; 6(4): 325-35, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21175222
15.
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Cell
; 131(6): 1072-83, 2007 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083098