Detalhe da pesquisa
1.
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype.
Proc Natl Acad Sci U S A
; 115(48): 12301-12306, 2018 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30429323
2.
Repurposing Approved Drugs as Inhibitors of Kv7.1 and Nav1.8 to Treat Pitt Hopkins Syndrome.
Pharm Res
; 36(9): 137, 2019 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31332533
3.
A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy.
Epilepsia
; 59(4): 802-813, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29574705
4.
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Proc Natl Acad Sci U S A
; 110(29): E2724-32, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23818614
5.
APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease.
J Clin Invest
; 134(5)2024 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38227370
6.
Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series.
ACS Med Chem Lett
; 12(4): 593-602, 2021 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33859800
7.
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Bioorg Med Chem Lett
; 20(22): 6812-5, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855211
8.
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
Bioorg Med Chem
; 18(22): 7816-25, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20965738
9.
The effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons.
Anesth Analg
; 109(2): 632-40, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608841
10.
GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.
Br J Pharmacol
; 175(12): 2272-2283, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29150838
11.
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
ACS Med Chem Lett
; 9(2): 125-130, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456800
12.
Discovery of a Series of Indazole TRPA1 Antagonists.
ACS Med Chem Lett
; 8(6): 666-671, 2017 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28626530
13.
Validation of ion channel targets.
Channels (Austin)
; 9(6): 376-9, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26556675
14.
A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability.
Br J Pharmacol
; 172(10): 2654-70, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25625641
15.
High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition.
J Biomol Screen
; 8(3): 332-9, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12857387
16.
N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy.
ACS Med Chem Lett
; 2(6): 481-4, 2011 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900334
17.
Sodium channel inhibitor drug discovery using automated high throughput electrophysiology platforms.
Comb Chem High Throughput Screen
; 12(1): 107-22, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19149496