A Comparative Study of Narrow/Ultra-Wideband Microwave Sensors for the Continuous Monitoring of Vital Signs and Lung Water Level.

This article presents an in-depth investigation of wearable microwave antenna sensors (MASs) used for vital sign detection (VSD) and lung water level (LWL) monitoring. The study looked at two different types of MASs, narrowband (NB) and ultra-wideband (UWB), to decide which one was better. Unlike recent wearable respiratory sensors, these antennas are simple in design, low-profile, and affordable. The narrowband sensor employs an offset-feed microstrip transmission line, which has a bandwidth of 240 MHz at -10 dB reflection coefficient for the textile substrate. The UWB microwave sensor uses a CPW-fed line to excite an unbalanced U-shaped radiator, offering an extended simulated operating bandwidth from 1.5 to 10 GHz with impedance matching ≤-10 dB. Both types of microwave sensors are designed on a flexible RO 3003 substrate and textile conductive fabric attached to a cotton substrate. The specific absorption rate (SAR) of the sensors is measured at different resonant frequencies on 1 g and 10 g of tissue, according to the IEEE C95.3 standard, and both sensors meet the standard limit of 1.6 W/kg and 2 W/kg, respectively. A simple peak-detection algorithm is used to demonstrate high accuracy in the detection of respiration, heartbeat, and lung water content. Based on the experimental results on a child and an adult volunteer, it can be concluded that UWB MASs offer superior performance when compared to NB sensors.

An Improved Performance Radar Sensor for K-Band Automotive Radars.

This paper presents a new radar sensor configuration of a planar grid antenna array (PGAA) for automotive ultra-wideband (UWB) radar applications. For system realisation, the MIMO concept is adopted. The proposed antenna is designed to operate over the 24 GHz frequency band. It is based on split-ring resonator (SRR) elements to enhance the operating bandwidth and increase the antenna gain, leading to a better-performing radar system. The PGAA consists of thirty-one radiating elements, in which each element excitation is obtained using a common transmission line centre fed by a 50 Ω coaxial probe. By introducing a superstrate dielectric layer at a distance of λ/2 from the top of the antenna array, the PGAA gain and impedance bandwidth are further improved. The gain is improved by 2.7 dB to reach 16.5 dBi at 24 GHz, and the impedance bandwidth is enhanced to 9.3 GHz (37.7%). The measured impedance bandwidth of the proposed antenna array ranges from 20 GHz to 29.3 GHz for a reflection coefficient (S11) of less than -10 dB. The proposed antenna is validated for automotive applications.

Performance Improvement of Substrate Integrated Cavity Fed Dipole Array Antenna Using ENZ Metamaterial for 5G Applications.

This paper exhibits a high-gain, low-profile dipole antenna array (DAA) for 5G applications. The dipole element has a semi-triangular shape to realize a simple input impedance regime. To reduce the overall antenna size, a substrate integrated cavity (SIC) is adopted as a power splitter feeding network. The transition between the SIC and the antenna element is achieved by a grounded coplanar waveguide (GCPW) to increase the degree of freedom of impedance matching. Epsilon-near-zero (ENZ) metamaterial technique is exploited for gain enhancement. The ENZ metamaterial unit cells of meander shape are placed in front of each dipole perpendicularly to guide the radiated power into the broadside direction. The prospective antenna has an overall size of 2.58 λg3 and operates from 28.5 GHz up to 30.5 GHz. The gain is improved by 5 dB compared to that of the antenna without ENZ unit cells, reaching 11 dBi at the center frequency of 29.5 GHz. Measured and simulated results show a reasonable agreement.

Effect of quadriceps and hamstrings muscle cooling on standing balance in healthy young men.

OBJECTIVE: The present study compared the effect of quadriceps and hamstring muscle cooling on standing balance in healthy young men. METHODS: Thirty healthy young men (18-30 years) participated in the study. The participants were randomly assigned to three groups (n=10 each): quadriceps cooling (QC), hamstring cooling (HC), or control group (no cooling). Participants in the QC and HC groups received 20 minutes of cooling using a cold pack (gel pack), placed on the anterior thigh (from the apex of the patella to the mid-thigh) and the posterior thigh (from the base of the popliteal fossa to the mid-thigh), respectively. Balance score including unilateral stance was measured at baseline and immediately after the application of the cold pack. RESULTS: No significant difference in the balance score was noted in any group after the application of the cold pack (p⟩0.05). Similarly, no significant differences in post-test balance score were noted among the three groups (p⟩0.05). CONCLUSIONS: Cooling of the quadriceps and hamstring muscles has no immediate effect on standing balance in healthy young men. However, longitudinal studies are warranted to investigate the long-term effects of cooling these muscles on standing balance.

Left atrial pump strain predicts long-term survival after transcatheter aortic valve implantation.

BACKGROUND: This study aims at investigating left atrial (LA) deformation by left atrial reservoir (LARS) and pump strain (LAPS) and its implications for long-term survival in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). METHODS: Speckle tracking echocardiography was performed in 198 patients with severe AS undergoing TAVI. Association of strain parameters with cardiovascular mortality was determined. RESULTS: Over a follow-up time of 5 years, 49 patients (24.7%) died. LAPS was more impaired in non-survivors than survivors (P = 0.010), whereas no difference was found for LARS (P = 0.114), LA ejection fraction (P = 0.241), and LA volume index (P = 0.292). Kaplan-Meier analyses yielded a reduced survival probability according to the optimal threshold for LAPS (P = 0.002). A more impaired LAPS was associated with increased mortality risk (HR 1.12 [95% CI 1.02-1.22]; P = 0.014) independent of LVEF, LAVI, age, and sex. Addition of LAPS improved multivariable echocardiographic (LVEF, LAVI) and clinical (age, sex) models with potential incremental value for mortality prediction (P = 0.013 and P = 0.031, respectively). In contrast, LARS and LAVI were not associated with mortality. CONCLUSIONS: In patients undergoing aortic valve replacement for severe AS, LAPS was impaired in patients dying during long-term follow-up after TAVI, differentiated survivors from non-survivors, was independently associated with long-term mortality, and yielded potential incremental value for survival prediction after TAVI. LAPS seems useful for risk stratification in severe AS and timely valve replacement.

Phenomenological and statistical analyses of turbulence in forced convection with temperature-dependent viscosity under non-Boussinesq condition.

In this work, Thermal Large Eddy Simulation (TLES) is performed to study the behavior of weakly compressible Newtonian fluids with anisotropic temperature-dependent viscosity in forced convection turbulent flow. A systematic analysis of variable-viscosity effects, isolated from gravity, with relevance to industrial cooling/heating applications is being carried out. A LES of a planar channel flow with significant heat transfer at a low Mach number was performed to study effects of fluid property variation on the near-wall turbulence structure. In this flow configuration the top wall is maintained at a higher temperature (T hot ) than the bottom wall (T cold ). The temperature ratio (R θ = T hot /T cold ) is fixed at 1.01, 2 and 3 to study the effects of property variations at low Mach number. Results indicate that average and turbulent fields undergo significant changes. Compared with isothermal flow with constant viscosity, we observe that turbulence is enhanced in the cold side of the channel, characterized by locally lower viscosity whereas a decrease of turbulent kinetic energy is found at the hot wall. The turbulent structures near the cold wall are very short and densely populated vortices but near the hot wall there seems to be a long streaky structure or large elongated vortices. Spectral study reveals that turbulence is completely suppressed at the hot side of the channel at a large temperature ratio because no inertial zone is obtained (i.e. index of Kolmogorov scaling law is zero) from the spectra in these region.

The prevalence and impact of age and gender on rehabilitation outcomes in spinal cord injury in India: a retrospective pilot study.

STUDY DESIGN: Retrospective, 1 year case series. OBJECTIVES: To analyze the relationship between gender, age, injury-related variables and rehabilitation outcomes in patients with spinal cord injury (SCI). SETTING: Tertiary Rehabilitation Center, Inpatient rehabilitation unit, India. METHODS: The data from a series of SCI cases were analyzed. Each case was followed from admission into the hospital until their discharge. Patients were described according to age, gender, etiology of SCI, neurological classification, medical complications, American spinal injury association (ASIA) classification, length of rehabilitation stay and spinal cord independence measure (SCIM). RESULTS: Forty-seven new SCI cases, 37 (78.7%) male and 10 (21.3%) female patients, were reported over a 1-year period during 2009-2010. Male patients were younger than the female ones, but the difference was not statistically significant. There was no statistically significant relationship between age or gender, and the following SCI variables: ASIA classification, neurological classification, SCI complications and length of stay (P>0.05). Traumatic etiology and Pott's disease was found be related with gender (P<0.05). There was no statistically significant relationship between age or gender and SCIM score at admission or discharge (P>0.05). CONCLUSION: Age and gender are not significantly related to outcomes of rehabilitation or characteristics of SCI in this sample. Further research is needed to confirm the generalizability of these findings and to identify which factors contribute more strongly to SCI rehabilitation outcomes.

Phenolic compound and fatty acid properties of some microalgae species isolated from Erbil City.

The total phenolic compound and fatty acid profiles of lipids from microalgae are unique. The present study was designed to investigate aqueous, ethanolic and acetone extracts of several algae (Spirogyra sp., Spirulina sp.,Chlorella sp and Chara sp.) for their antioxidant capacities of the crude extracts and fractions by radical scavenging activity against the stable radical 1,1-diphenyl-2-picrylhydrazyl DPPH as well; total phenolic content. The results showed that Spirulina sp. indicated significantly higher total phenolic compound and antioxidant activities compared to the other species (P < 0.05) and acetone extracts showed higher quantity among three extracts. The fatty acids analysis using High performance liquid chromatography -HPLC showed the presence of palmitic acid, stearic acid, oleic acid, and linoleic acid, palmitic acid showed high quantity than other fatty acid classes in all studied algae. This study concluded that high antioxidant capacity of microalgae could be inspected for different industrial applications.

Mathematical Modeling and Control of COVID-19 Using Super Twisting Sliding Mode and Nonlinear Techniques.

Since the outbreak of the COVID-19 epidemic, several control strategies have been proposed. The rapid spread of COVID-19 globally, allied with the fact that COVID-19 is a serious threat to people's health and life, motivated many researchers around the world to investigate new methods and techniques to control its spread and offer treatment. Currently, the most effective approach to containing SARS-CoV-2 (COVID-19) and minimizing its impact on education and the economy remains a vaccination control strategy, however. In this paper, a modified version of the susceptible, exposed, infectious, and recovered (SEIR) model using vaccination control with a novel construct of active disturbance rejection control (ADRC) is thus used to generate a proper vaccination control scheme by rejecting those disturbances that might possibly affect the system. For the COVID-19 system, which has a unit relative degree, a new structure for the ADRC has been introduced by embedding the tracking differentiator (TD) in the control unit to obtain an error signal and its derivative. Two further novel nonlinear controllers, the nonlinear PID and a super twisting sliding mode (STC-SM) were also used with the TD to develop a new version of the nonlinear state error feedback (NLSEF), while a new nonlinear extended state observer (NLESO) was introduced to estimate the system state and total disturbance. The final simulation results show that the proposed methods achieve excellent performance compared to conventional active disturbance rejection controls.

The Relationship between Tumor Necrosis Factor Alpha and Left Ventricular Diastolic Function.

INTRODUCTION: Left ventricular (LV) diastolic dysfunction is a common condition. Tumor necrosis factor (TNF) alpha is an inflammatory cytokine that plays a role in the development of cardiac structural changes leading to LV diastolic dysfunction. The aim of this study was to examine the relationship between serum levels of TNF alpha levels and LV diastolic function. METHODS: A case-control study that included 40 patients with echocardiographic evidence of LV diastolic dysfunction and 40 healthy controls. Standard transthoracic echocardiography was performed to assess LV and left atrial volumes, systolic and diastolic function according to the current recommendations. Serum TNF alpha levels were assessed using a specific enzyme-linked immunosorbent assay kit. RESULTS: Mean serum TNF alpha level was significantly higher in the study group 3.48 ± 1.06 versus 1.22 ± 0.36 pg/ml in the control group, P < 0.001. It was also higher in patients with Grade 2 diastolic dysfunction (n = 16) 3.91 ± 1.21 versus 3.18 ± 0.86 pg/ml in those with Grade 1 diastolic dysfunction (n = 24), P = 0.03. TNF alpha showed a strong correlation with indexed left atrial volume (LAVI) in the study group but not in controls. Mean serum TNF showed a trend toward increase with worsening heart failure symptoms in the form of increased the New York Heart Association functional class. CONCLUSION: Serum TNF alpha level is elevated in patients with LV diastolic dysfunction and is correlated to LAVI in such patients. Patients with Grade 2 diastolic dysfunction have higher serum levels of TNF alpha compared to those with Grade 1 diastolic dysfunction. TNF alpha levels increase with worsening heart failure symptoms.

Effect of localised vibration on muscle strength in healthy adults: a systematic review.

OBJECTIVE: To investigate the effects of local vibration on muscle strength in healthy adults. DATA SOURCES: The electronic databases PubMed, CINAHL, Scopus and Web of Science were searched using a combination of the following keywords: vibration, vibration therapy, power, maximal voluntary contraction, performance, rate of force development and vibratory exercise. In addition, the Medical Subject Headings 'vibration', 'strength' and 'exercise' were used. The bibliographical search was limited to articles published in English. STUDY SELECTION: Trials that evaluated the effect of localised vibration on muscle strength in healthy humans were included. DATA EXTRACTION: Two independent evaluators verified the quality of the selected studies using the PEDro Scale and the Cochrane Collaboration's tool for assessing the risk of bias. Muscle strength was calculated for each intervention. RESULTS: In total, 29 full-text studies were assessed for eligibility. Eighteen studies did not match the inclusion criteria, and were excluded. The 11 studies included in this review had an average PEDro score of 5.36/10. Most of the studies reported significant improvements in muscle strength after the application of local vibration. There was considerable variation in the vibration training parameters and target muscle location. CONCLUSIONS: The use of local vibration on the target muscle can enhance muscle strength in healthy adults. Further well-designed controlled studies are required to confirm the effect of local vibration training on muscle strength.

Management of choledocholithiasis after previous gastrectomy.

Common bile duct stones in patients with a previous gastrectomy can be a technical challenge because of the altered anatomy. This paper presents the successful management of two such patients using non-traditional techniques as conventional endoscopic retrograde cholangiopancreatography was not possible.

Phenolic compound and fatty acid properties of some microalgae species isolated from Erbil City

Abstract The total phenolic compound and fatty acid profiles of lipids from microalgae are unique. The present study was designed to investigate aqueous, ethanolic and acetone extracts of several algae (Spirogyra sp., Spirulina sp.,Chlorella sp and Chara sp.) for their antioxidant capacities of the crude extracts and fractions by radical scavenging activity against the stable radical 1,1-diphenyl-2-picrylhydrazyl DPPH as well; total phenolic content. The results showed that Spirulina sp. indicated significantly higher total phenolic compound and antioxidant activities compared to the other species (P 0.05) and acetone extracts showed higher quantity among three extracts. The fatty acids analysis using High performance liquid chromatography HPLC showed the presence of palmitic acid, stearic acid, oleic acid, and linoleic acid, palmitic acid showed high quantity than other fatty acid classes in all studied algae. This study concluded that high antioxidant capacity of microalgae could be inspected for different industrial applications.

Resumo O composto fenólico total e os perfis de ácidos graxos dos lipídios das microalgas são únicos. O presente estudo foi desenhado para investigar extratos aquosos, etanólicos e acetona de várias algas (Spirogyra sp., Spirulina sp., Chlorella sp. e Chara sp.) Quanto às suas capacidades antioxidantes dos extratos brutos e frações por atividade de eliminação de radicais contra o radical estável 1,1-difenil-2-picrilhidrazil DPPH também; fenólico total. Os resultados mostraram que a Spirulina sp. indicaram atividade antioxidante e compostos fenólicos totais significativamente maiores em relação às outras espécies (P 0,05), e os extratos de acetona apresentaram maior quantidade entre os três extratos. A análise de ácidos graxos por cromatografia líquida de alta eficiência - HPLC mostrou a presença de ácido palmítico, ácido esteárico, ácido oleico e ácido linoleico; o ácido palmítico apresentou maior quantidade do que outras classes de ácidos graxos em todas as algas estudadas. Este estudo concluiu que a alta capacidade antioxidante pode ser inspecionada para diferentes aplicações industriais.

Phenolic compound and fatty acid properties of some microalgae species isolated from Erbil City / Propriedades do composto fenólico e dos ácidos graxos de algumas espécies de microalgas isoladas da cidade de Erbil

Food handlers plays a primary role in the transmission of pathogenically important protozoans and helminth parasites. This study was aimed to evaluate the prevalence of intestinal pathogenic protozoans and helminth parasites among food handlers in and around University of Malakand, Lower Dir, Pakistan. Stool samples were collected from 642 food handlers (all of male) in a cross-sectional study from January to November, 2017. Wet Mount Techniques and concentration methods by using salt and formol­ether solutions. Three hundred and eighty four cases (59.8%) were found infected with one more parasites. Most of the individuals were found infected with helminth (47.6%) as compared to intestinal protozoans (0.93%). Seventy two cases (11.2%) of the cases presented mixed infection with both intestinal protozoan and helminth parasites. The order of prevalence for intestinal helminth was Ancylostoma duodenale (n = 258, 40.1%), followed by Taeniasa ginata (n=96, 14.9%) Ascaris lumbricoides (n = 54, 8.40%) and Trichuris trichura (n=30, 4.60%). For intestinal protozoa, Entamoeba histolytica/díspar (n = 36, 5.64%) was the only protozoan detected. Mono-parasitism was higher than poly-parasitism. Family size income and education level were the factors significantly (P<0.05) associated in the parasites prevalence. Current research showed that IPIs are primarily the foodborne pathogens still an important public health problem in Pakistan. Effective control programs on parasitic diseases transfer and their associated factors are recommended.

Os manipuladores de alimentos desempenham um papel fundamental na transmissão de protozoários e helmintos parasitas patogenicamente importantes. Este estudo teve como objetivo avaliar a prevalência de protozoários patogênicos intestinais e helmintos parasitas entre manipuladores de alimentos na Universidade de Malakand, Lower Dir, Paquistão. Amostras de fezes foram coletadas de 642 manipuladores de alimentos (todos do sexo masculino) em um estudo transversal de janeiro a novembro de 2017. Técnicas de montagem úmida e métodos de concentração usando soluções de sal e formol-éter. Trezentos e oitenta e quatro casos (59,8%) foram encontrados infectados com mais um parasita. A maioria dos indivíduos foi encontrada infectada por helmintos (47,6%) em comparação com protozoários intestinais (0,93%). Setenta e dois casos (11,2%) dos casos apresentavam infecção mista com protozoários intestinais e helmintos parasitas. A ordem de prevalência de helmintos intestinais foi Ancylostoma duodenale (n = 258, 40,1%), seguido por Taeniasa ginata (n = 96, 14,9%) Ascaris lumbricoides (n = 54, 8,40%) e Trichuris trichura (n = 30, 4,60 %). Para protozoários intestinais, Entamoeba histolytica / dispar (n = 36, 5,64%) foi o único protozoário detectado. Monoparasitismo foi maior do que poliparasitismo. A renda familiar e o nível de escolaridade foram os fatores significativamente (P <0,05) associados na prevalência de parasitos. A pesquisa atual mostrou que os IPIs são principalmente os patógenos de origem alimentar, ainda um importante problema de saúde pública no Paquistão. Programas eficazes de controle da transferência de doenças parasitárias e seus fatores associados são recomendados.

Clinical characteristics of 110 miliary tuberculosis patients from a low HIV prevalence country.

SETTING: A university teaching hospital in Karachi, Pakistan. OBJECTIVE: To define the clinical characteristics and outcome of miliary tuberculosis (TB) patients from a low human immunodeficiency virus (HIV) prevalence country. DESIGN: Review of adult miliary TB patients admitted between 1994 and 2001. Clinical characteristics of those dying from miliary TB were compared with those of the survivors. RESULTS: Most of the 110 cases reviewed were middle aged or elderly, with a female preponderance. An underlying medical condition was present in 47%. Presenting symptoms were of several weeks' duration, and mostly constitutional (fever and weight loss). Common laboratory findings included anaemia (62%), lymphopaenia (71%), hyponatraemia (74%), elevated serum alkaline phosphatase (57%) and hypoalbuminaemia (92%). Typical miliary pattern was observed in 77% of radiographs. Sputum smear and culture were positive in respectively 36% and 52% of those tested. Biopsy was performed in selected patients. Mean hospital stay was 8.8 days, and mortality was 30%. Those who died were significantly older than survivors and had a more fulminant course. Presence of altered mental status, lung crackles, leucocytosis, thrombocytopaenia and the need for ventilation were associated with increased mortality. CONCLUSION: Miliary TB carries a high mortality. It should be considered in patients who present with prolonged systemic symptoms. A positive TB culture or biopsy is needed to establish a diagnosis.

Two new triterpene lactones from Centaurium pulchellum.

Two new triterpene lactones, centauriol (1) and centaurione (2) were isolated from the whole plant of Centaurium pulchellum. Their structures were determined by spectral data.

Rapid identification of neonatal sepsis.

OBJECTIVE: To achieve rapid identification of neonatal sepsis. SETTING: Neonatal Intensive care unit (NICU) of a teaching hospital. METHOD: We evaluated fifty neonates who were admitted with clinical features suggesting sepsis or who had principal risk factors, e.g. Prematurity (< 36 weeks), Low birth weight (< 2.5 kg), H/o maternal pyrexia or prolonged rupture of membranes, birth asphyxia, unbooked cases or instrumentation. Five tests, i.e., Total Leukocyte Count (T.L.C.), Absolute Neutrophil Count, Immature/Total Neutrophil ratio (I.T. ratio), Platelet count and C-Reactive protein were used for rapid diagnosis of neonatal sepsis. RESULTS: C-reactive protein (C.R.P.) and absolute Neutrophil count had a sensitivity of over 60% with a specificity of 50%. White blood cell count had a specificity of 93% but a sensitivity of 14%. CONCLUSION: None of the tests used alone were reliable, but when in combination these five tests may help to diagnose sepsis within a few hours. Also, if the tests show a high negative predictive value, the neonate can be discharged early from the hospital, stopping the antibiotics, thereby reducing the cost of treatment and anxiety of the family.

Neonatal sepsis: an etiological study.

OBJECTIVE: A periodic review of neonatal sepsis to asses any change in the infecting organism. METHOD: A prospective study was conducted at HMC and ASH, Karachi. The babies suspected to have or developed sepsis any time during hospitalization were investigated to establish the diagnosis and isolate the causative organism. Blood culture was taken at the time of admission or when sepsis was suspected. RESULTS: Out of 109 episodes of blood culture proven sepsis 68 presented as early onset (within 48 hours of birth) and 41 as late onset sepsis (after 48 hours of birth). In early onset group Gram -ve and Gram +ve organisms were almost equal, i.e. 33 and 35 respectively. Among the gram -ve organism most of the cases were due to Klebsiella sp, and Enterococcus was the commonest Gram +ve organism. In late onset group majority of infections were due to gram +ve organisms, i.e. 30 out of 41. Staph. aureus and Staph. epidermidis were commonest. The organisms were least sensitive to Ampicillin (< 20%) and highly sensitive to Amikacin (90% to 100%), Cefotaxime was also seen as a good choice of antibiotic with sensitivity of (84%-89%). CONCLUSION: Gram +ve organisms were the main cause of neonatal sepsis. Klebsiella sp. is still the commonest organism causing early onset sepsis. The data must be periodically reviewed and antibiotic policy revised accordingly.

Effect of gender on strength gains after isometric exercise coupled with electromyographic biofeedback in knee osteoarthritis: a preliminary study.

OBJECTIVE: The objective of this trial was to evaluate the effect of gender on strength gains after five week training programme that consisted of isometric exercise coupled with electromyographic biofeedback to the quadriceps muscle. MATERIALS AND METHODS: Forty-three (20 men and 23 women) patients with knee osteoarthritis (OA), were placed into two groups based on their gender. Both groups performed isometric exercise coupled with electromyographic biofeedback for five days a week for five weeks. RESULTS: Both groups reported gains in muscle strength after five week training. However, the difference was found to be statistically insignificant between the two groups (P=0.224). CONCLUSION: The results suggest that gender did not affect gains in muscle strength by isometric exercise coupled with electromyographic biofeedback in patients with knee OA.

Effect of angiotensin converting enzyme gene I/D polymorphism in patients with metabolic syndrome in North Indian population.

BACKGROUND: Numerous studies have investigated the effect of angiotensin converting enzyme (ACE) gene I/D polymorphism and various cardiovascular risk factors in different populations with varied results. Currently, the association of ACE gene polymorphism with metabolic syndrome has not been studied in North Indians. While studies assessing the effect with polymorphism on each of the components of metabolic syndrome separately are present, data regarding the metabolic syndrome per se are sparse. The present study evaluated the effect of ACE gene I/D polymorphism in patients with metabolic syndrome in North Indian population at a tertiary care centre. METHODS: Fifty subjects, with thirty cases of metabolic syndrome (NCEP/ATP III guidelines, 2004) and twenty age and gender matched healthy controls were chosen. Detailed history was reviewed and clinical examination of the subjects was carried out. Relevant investigations including blood glucose (fasting and post prandial), blood urea, serum creatinine and serum lipids were done. DNA of cases and controls was analysed for I/D polymorphism using polymerase chain reaction. RESULTS: D/D genotype was more frequent in patients with metabolic syndrome as compared with healthy controls (P < 0.05). Systolic blood pressure (SBP) and diastolic blood pressure (DBP) was significantly higher in the D/D genotype than I/D and I/I genotypes (P < 0.05). Our study also showed positive association between obesity, fasting blood glucose and ACE gene polymorphism while no association was found with triglycerides and high density lipoprotein cholesterol. The I/I group was significantly associated with waist circumference and fasting blood glucose (P < 0.05). CONCLUSION: Our study clearly showed that metabolic syndrome was associated with ACE gene polymorphism. However due to less number of subjects in the study further studies are needed to corroborate our results.