RESUMO
As the replacement of a hydrogen atom by a fluorine atom in a compound can have an important impact on its biological properties, the development of methods allowing the introduction of a fluorine atom is of great importance. The scope and limitations of the ring expansion of cyclic 2-hydroxymethyl amines induced by diethylaminosulfur trifluoride (DAST) to produce cyclic ß-fluoro amines was studied as well as the enantioselectivity of the process.
Assuntos
Aminas/síntese química , Amino Álcoois/química , Dietilaminas/química , Flúor/química , Aminas/química , Ciclização , Estrutura Molecular , EstereoisomerismoRESUMO
An iridium-catalyzed hydrogen transfer has been developed in the presence of p-benzoquinone, allowing the synthesis of a diversity of substituted benzofurans, benzothiophenes, and indoles from substituted benzylic alcohols.
Assuntos
Benzofuranos/química , Benzofuranos/síntese química , Álcoois Benzílicos/química , Álcoois Benzílicos/síntese química , Indóis/química , Indóis/síntese química , Irídio/química , Tiofenos/química , Tiofenos/síntese química , Catálise , Estrutura Molecular , EstereoisomerismoRESUMO
The monoalkylation of acetonitrile by primary alcohols was achieved in a one-pot sequence in the presence of iridium catalysts. A diversity of nitriles has been obtained from aryl- and alkyl-methanols in excellent yield.