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1.
J Shoulder Elbow Surg ; 31(6): 1184-1192, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34999235

RESUMO

BACKGROUND: Glenohumeral internal rotation deficit is generally recognized as a risk factor for throwing disability in baseball players. However, the pathology, timing of onset, role in the onset of humeral retrotorsion angle (HTA) and soft tissue extensibility (STE), and the relationship with age remain unclear. Therefore, the purpose of this cross-sectional study was to investigate age-related glenohumeral internal rotation deficit, HTA, and STE in Japanese baseball players and determine whether these factors correlate with throwing disability. METHODS: Participants were 172 male baseball players divided into a symptomatic group (n = 68) and an asymptomatic group (n = 104). The mean age at examination was 15.4 ± 3.2 (range, 8-22) years. Measurement items were range of motion of bilateral internal and external rotation at 90° abduction (2ndIR and 2ndER, respectively), bilateral HTA, and posterior shoulder muscle elasticity. Correlations of age, symptom, and dominance with these measurements were investigated, and significant bilateral differences in HTA and STE by age and symptom were analyzed. RESULTS: HTA and 2ndER of the dominant side were significantly greater than those of the nondominant side in those over the age of 13 years in both the asymptomatic and symptomatic groups. In contrast, 2ndIR of the dominant side was significantly smaller than that of the nondominant side in those over the age of 13 years in both the asymptomatic and symptomatic groups. The difference in HTA between the dominant and nondominant sides increased and then plateaued at 12° after the age of 16 years. STE was observed only in the symptomatic group, and the value of STE was significantly greater in players aged >16 years compared with that in players aged <12 years (P = .001). Muscle elasticity did not differ significantly between sides and showed no correlation with STE. CONCLUSIONS: The difference in HTA between the dominant and nondominant sides increased with age until 16 years old regardless of symptoms. STE in the dominant side was observed only in symptomatic baseball players after the age of 13 years and increased with age, plateauing around the age of 16 years. Posterior shoulder muscle elasticity was not indicated as a cause of STE.


Assuntos
Beisebol , Articulação do Ombro , Adolescente , Beisebol/fisiologia , Estudos Transversais , Humanos , Úmero/fisiologia , Masculino , Amplitude de Movimento Articular/fisiologia , Ombro/fisiologia , Articulação do Ombro/fisiologia
2.
J Sports Sci Med ; 20(2): 284-290, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34211321

RESUMO

The objective of the study was to establish the prevalence of clinical hip osteoarthritis in current and former professional footballers and to explore its consequences on hip function and health-related quality of life (HRQoL). A cross-sectional study by means of questionnaire was conducted among current and former professional footballers fulfilling the following inclusion criteria: (1) male (2) active or retired professional footballer (3) member of FIFPRO (Football Players Worldwide) (4) between 18 and 50 years old (5) could read and understand texts in French, Spanish, or English. Controls (matched for: gender, age, body weight and height) were also recruited. The main outcome measures were clinical hip osteoarthritis, hip function and HRQoL. Questionnaires were sent to 2,500 members of which 1,401 participated (1,000 current and 401 former professional footballers). Fifty-two controls were recruited. Prevalence of hip osteoarthritis was 2% among current and 8% among former professional footballers. Hip function was significantly (p ≤ 0.001) lower in both types of footballers with hip osteoarthritis than in footballers without hip osteoarthritis and controls. Current and former professional footballers with hip osteoarthritis reported significantly lower physical health scores (p = 0.032, p = 0.002) than those without. Hip osteoarthritis led to a significantly lower score in the physical (p = 0.004) and mental (p = 0.014) component of HRQoL in former footballers compared to the controls, while in current footballers only the physical component was significantly (p = 0.012) lower compared to the controls. Hip osteoarthritis has a higher prevalence in former than in current professional footballers and impacts hip function and HRQoL negatively.


Assuntos
Osteoartrite do Quadril/epidemiologia , Osteoartrite do Quadril/psicologia , Qualidade de Vida , Futebol/lesões , Adulto , Estudos Transversais , Inquéritos Epidemiológicos , Quadril/fisiopatologia , Humanos , Masculino , Análise por Pareamento , Osteoartrite do Quadril/fisiopatologia , Prevalência
3.
Clin J Sport Med ; 27(5): 487-492, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27623187

RESUMO

OBJECTIVE: To determine the 12-month incidence and comorbidity of symptoms of common mental disorders (CMD) among European professional footballers and to explore the association of potential stressors with the health conditions under study among those European professional footballers. DESIGN: Observational prospective cohort study with a follow-up period of 12 months. PARTICIPANTS: Male professional footballers from 5 European countries (n = 384 at baseline). ASSESSMENT OF RISK FACTORS: Adverse life events, conflicts with trainer/coach, and career dissatisfaction were explored by using validated questionnaires. MAIN OUTCOME MEASURES: Symptoms of distress, anxiety/depression, sleep disturbance, and adverse alcohol use were assessed using validated questionnaires. RESULTS: A total of 384 players (mean age of 27 years old; mean career duration of 8 years) were enrolled, of which 262 completed the follow-up period. The incidence of symptoms of CMD were 12% for distress, 37% for anxiety/depression, 19% for sleep disturbance, and 14% for adverse alcohol use. Over the follow-up period of 12 months, approximately 13% of the participants reported 2 symptoms, 5% three symptoms, and 3% four symptoms. Professional footballers reporting recent adverse life events, a conflict with trainer/coach, or career dissatisfaction were more likely to report symptoms of CMD, but statistically significant associations were not found. CONCLUSIONS: The 12-month incidence of symptoms of CMD among European professional footballers ranged from 12% for symptoms of distress to 37% for symptoms of anxiety/depression. A professional football team typically drawn from a squad of 25 players can expect symptoms of CMD to occur among at least 3 players in one season.


Assuntos
Depressão/epidemiologia , Transtornos Mentais/epidemiologia , Transtornos do Sono-Vigília/epidemiologia , Futebol , Adulto , Atletas , Humanos , Incidência , Masculino , Estudos Prospectivos , Inquéritos e Questionários , Adulto Jovem
4.
Knee Surg Sports Traumatol Arthrosc ; 25(10): 3179-3185, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27488101

RESUMO

PURPOSE: The primary aim was to establish the association between osteoarthritis (OA) and the occurrence and comorbidity of symptoms of common mental disorders (CMD: distress, anxiety/depression, sleep disturbance, adverse alcohol use) in a group of former elite athletes (rugby, football, ice hockey, Gaelic sports and cricket). A secondary aim was to explore this association in the subgroups of sports. METHODS: Cross-sectional analysis was performed on the baseline questionnaires from five prospective cohort studies conducted between April 2014 and January 2016 in former elite athletes of rugby, football, ice hockey, Gaelic sports and cricket. The presence of OA (diagnosed by a medical professional) was examined with a single question, and symptoms of CMD were evaluated through multiple validated questionnaires (4DSQ, GHQ-12, PROMIS, AUDIT-C). RESULTS: There was a significant association between OA and symptoms of distress (OR 1.7, 95 % CI 1.2-2.6), sleep disturbance (OR 1.6, 95 % CI 1.1-2.3), adverse alcohol use (OR 1.8, 95 % CI 1.2-2.6) and a comorbidity of symptoms of CMD (OR 1.5, 95 % CI 1.0-2.1) in former elite athletes. CONCLUSION: OA might be a risk factor for developing symptoms of CMD in former elite athletes. The clinical relevance of this study is that an interdisciplinary approach to the clinical care and support of former elite athletes after their careers is advocated as the interaction between the physical and mental health issues occurring on the long term is complex. Monitoring OA among former elite athletes should be empowered while strategies to prevent symptoms worsening should be developed and implemented. The self-awareness, prevention and care of mental health problems that might occur after a professional sports career should also be addressed. LEVEL OF EVIDENCE: Level III.


Assuntos
Transtornos Relacionados ao Uso de Álcool/etiologia , Ansiedade/etiologia , Atletas/psicologia , Depressão/etiologia , Osteoartrite/psicologia , Transtornos do Sono-Vigília/etiologia , Esportes/psicologia , Adulto , Transtornos Relacionados ao Uso de Álcool/diagnóstico , Ansiedade/diagnóstico , Estudos Transversais , Depressão/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite/complicações , Osteoartrite/diagnóstico , Estudos Prospectivos , Fatores de Risco , Transtornos do Sono-Vigília/diagnóstico
5.
Knee Surg Sports Traumatol Arthrosc ; 24(12): 3934-3942, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26233596

RESUMO

PURPOSE: To explore the associations of severe musculoskeletal injuries (joint and muscles) and surgeries with symptoms of common mental disorders (distress, anxiety/depression, sleeping disturbance, adverse alcohol behaviour , smoking, adverse nutrition behaviour) among male European professional footballers. METHODS: Cross-sectional analyses were conducted on electronic questionnaires completed by professional footballers recruited from the national players' unions of Finland, France, Norway, Spain or Sweden. The number of severe (time loss of more than 28 days) musculoskeletal injuries (total, joint, muscle) and surgeries during a professional football career was examined through four questions, while symptoms of common mental disorders were evaluated through validated scales. RESULTS: A total of 540 professional footballers (mean age of 27 years; 54 % playing in the highest leagues) participated in the study. Sixty-eight per cent of the participants had already incurred one or more severe joint injuries and 60 % one or more severe muscle injuries. Prevalence of symptoms of common mental disorders ranged from 3 % for smoking to 37 % for anxiety/depression and 58 % for adverse nutrition behaviour. The number of severe musculoskeletal injuries during a football career was positively correlated with distress, anxiety and sleeping disturbance, while the number of surgeries was correlated with adverse alcohol behaviour and smoking. Professional footballers who had sustained one or more severe musculoskeletal injuries during their career were two to nearly four times more likely to report symptoms of common mental disorders than professional footballers who had not suffered from severe musculoskeletal injuries. CONCLUSION: It can be concluded that the number of severe musculoskeletal injuries and surgeries during a career is positively correlated and associated with symptoms of common mental disorders among male European professional footballers. This study emphasises the importance of applying a multidisciplinary approach to the clinical care and support of professional footballers, especially when a player faces lengthy periods without training and competition as a consequence of recurrent severe joint or muscle injuries. LEVEL OF EVIDENCE: III.


Assuntos
Ansiedade/epidemiologia , Traumatismos em Atletas/epidemiologia , Depressão/epidemiologia , Transtornos Mentais/epidemiologia , Sistema Musculoesquelético/lesões , Traumatismos Ocupacionais/epidemiologia , Futebol/lesões , Estresse Psicológico/epidemiologia , Adulto , Transtornos Relacionados ao Uso de Álcool/epidemiologia , Transtornos Relacionados ao Uso de Álcool/psicologia , Ansiedade/psicologia , Traumatismos em Atletas/psicologia , Traumatismos em Atletas/cirurgia , Estudos de Coortes , Estudos Transversais , Depressão/psicologia , Comportamento Alimentar , Finlândia/epidemiologia , França/epidemiologia , Humanos , Masculino , Transtornos Mentais/psicologia , Noruega/epidemiologia , Traumatismos Ocupacionais/psicologia , Traumatismos Ocupacionais/cirurgia , Prevalência , Estudos Prospectivos , Transtornos do Sono-Vigília/epidemiologia , Transtornos do Sono-Vigília/psicologia , Fumar/epidemiologia , Fumar/psicologia , Espanha/epidemiologia , Estresse Psicológico/psicologia , Inquéritos e Questionários , Suécia/epidemiologia , Adulto Jovem
6.
J Sports Sci Med ; 14(4): 811-8, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26664278

RESUMO

Evidence on the prevalence of symptoms related to distress, anxiety/depression or substance abuse/dependence, - typically referred to as symptoms of common mental disorders (CMD) - is lacking in European professional football (soccer). The aims of the present study were to investigate the prevalence of symptoms related to CMD (distress, anxiety/depression, sleeping disturbance, adverse alcohol behaviour, and adverse nutrition behaviour) in professional footballers from five European countries, and to explore associations of the outcome measures under study with life events and career dissatisfaction. A cross-sectional design was used. Questionnaires were distributed among professional footballers by the national players' unions in Finland, France, Norway, Spain and Sweden. The highest prevalence of symptoms related to common mental disorders were 18% for distress (Sweden), 43% for anxiety/depression (Norway), 33% for sleeping disturbance (Spain), 17% for adverse alcohol behaviour (Finland), and 74% for adverse nutrition behaviour (Norway). In Finland, France and Sweden, both life events and career dissatisfaction were associated with distress, anxiety/depression, adverse alcohol behaviour, and adverse nutrition behaviour. Results suggest the need for self-awareness in professional football about common mental disorders and a multidisciplinary approach by the medical team. Key pointsThe highest prevalence of symptoms related to common mental disorders were 18% for distress (Sweden), 43% for anxiety/depression (Norway), 33% for sleeping disturbance (Spain), 17% for adverse alcohol behaviour (Finland), and 74% for adverse nutrition behaviour (Norway).In Finland, France and Sweden, both life events and career dissatisfaction were associated with distress, anxiety/depression, adverse alcohol behaviour, and adverse nutrition behaviour.Our results suggest the need for self-awareness in professional football about common mental disorders and a multidisciplinary approach by the medical team.Further research based on longitudinal design should be conducted in order to acquire an insight into the causal relationship between symptoms related to common mental disorders and risk factors.

7.
J Sports Sci Med ; 14(2): 297-303, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25983578

RESUMO

Conservative therapies, mainly resting care for the damaged muscle, are generally used as a treatment for skeletal muscle injuries (such as muscle fragmentation). Several past studies reported that microcurrent electrical neuromuscular stimulation (MENS) facilitates a repair of injured soft tissues and shortens the recovery period. However, the effects of MENS on the regeneration in injured skeletal muscle are still unclear. The purpose of this study was to investigate the effect of MENS on the regenerative process of injured skeletal muscle and to elucidate whether satellite cells in injured skeletal muscle are activated by MENS by using animal models. Male C57BL/6J mice, aged 7 weeks old, were used (n = 30). Mice were randomly divided into two groups: (1) cardiotoxin (CTX)-injected (CX, n = 15) and (2) CTX-injected with MENS treatment (MX, n=15) groups. CTX was injected into tibialis anterior muscle (TA) of mice in CX and MX groups to initiate the necrosis-regeneration cycle of the muscle. TA was dissected 1, 2, and 3 weeks after the injection. Muscle weight, muscle protein content, the mean cross-sectional areas of muscle fibers, the relative percentage of fibers having central nuclei, and the number of muscle satellite cells were evaluated. MENS facilitated the recovery of the muscle dry weight and protein content relative to body weight, and the mean cross-sectional areas of muscle fibers in CTX-induced injured TA muscle. The number of Pax7-positive muscle satellite cells was increased by MENS during the regenerating period. Decrease in the percentages of fibers with central nuclei after CTX-injection was facilitated by MENS. MENS may facilitate the regeneration of injured skeletal muscles by activating the regenerative potential of skeletal muscles. Key pointsMicrocurrent electrical neuromuscular stimulation (MENS) facilitated the recovery of the relative muscle dry weight, the relative muscle protein content, and the mean cross-sectional areas of muscle fibers of injured TA muscle in mice.The number of satellite cells was increased by MENS during the regenerating phase of injured skeletal muscle.Decrease in the percentages of fibers with central nuclei was facilitated by MENS.MENS may facilitate the regeneration of injured skeletal muscles.

8.
Clin J Sport Med ; 20(1): 1-7, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20051727

RESUMO

OBJECTIVE: To investigate the incidence of acute injuries and soccer-related chronic pain from long-term training and during matches in adolescent players using natural grass turfs (NT) and artificial turfs (AT). DESIGN: Case-controlled prospective study. SETTING: Institutional-level Fédération Internationale de Football Association Medical Centre of Excellence. PARTICIPANTS: Youth soccer players (12-17 years of age) from 6 teams, with a predominant tendency to train on either NT or AT, were included. Of 332 players enrolled in this study, 301 remained to completion. INTERVENTIONS: Medically diagnosed acute injuries and chronic pain were recorded daily by team health care staff throughout 2005, and reports were provided monthly to the authors. ASSESSMENT OF RISK FACTORS: Noninvasive prospective study. INDEPENDENT VARIABLES: Age and turf type. MAIN OUTCOME MEASURES: Acute injuries per 1000 player hours on each surface and chronic complaints per 1000 player hours were evaluated according to frequency of surface used > or = 80% of the time. Incidence rate ratio (IRR) of acute injuries and chronic complaints during play on NT and AT was calculated. RESULTS: There was no significant difference in the incidence of acute injuries between the 2 surfaces during training and competition. However, the AT group showed a significantly higher incidence of low back pain during training (IRR, 1.62; 95% confidence interval, 1.06-2.48). Early adolescence and prolonged training hours were factors associated with an increased incidence of chronic pain in the AT group. CONCLUSION: Adolescent players routinely training on AT for prolonged periods should be carefully monitored, even on AT conforming to new standards.


Assuntos
Traumatismos em Atletas/epidemiologia , Dor/epidemiologia , Poaceae , Futebol/lesões , Doença Aguda , Adolescente , Traumatismos em Atletas/etiologia , Estudos de Casos e Controles , Criança , Doença Crônica , Intervalos de Confiança , Humanos , Incidência , Japão/epidemiologia , Masculino , Dor/etiologia , Estudos Prospectivos , Fatores de Risco
9.
BMJ Open ; 10(6): e036775, 2020 06 21.
Artigo em Inglês | MEDLINE | ID: mdl-32565473

RESUMO

OBJECTIVES: To determine (1) the prevalence of ankle osteoarthritis (OA) among former professional football and rugby players, (2) assess the association between ankle injuries or ankle surgeries with ankle OA, and (3) compare the mental and physical quality of life (QoL) between former professional football and rugby players with and without OA. METHODS: We conducted a questionnaire-based observational study with a cross-sectional design. Former professional football and rugby players were recruited by the Football Players Worldwide and the International Rugby Players. Information concerning ankle OA, sustained ankle injuries and ankle surgeries was gathered (medical record or most recent medical professional). Health-related QoL was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) physical and mental health scores. RESULTS: Overall, 553 former professional football (n=401) and rugby (n=152) players were enrolled in the study (response rate of 56%). Ankle OA prevalence among former professional football and rugby players was 9.2% and 4.6%, respectively. Football players were more likely to suffer from ankle OA following every ankle injury and/or surgery. Football and rugby players with ankle OA had similar PROMIS physical and mental health scores to the norm for the general population. CONCLUSION: Former professional football and rugby players had higher ankle OA prevalence than the general population (3.4%). Football players are more likely to suffer from ankle OA following every ankle injury and/or surgery. No clinically relevant difference was seen for physical or mental health-related QoL among football and rugby players. Preventive measures for ankle injuries are recommended.


Assuntos
Traumatismos do Tornozelo/epidemiologia , Articulação do Tornozelo/fisiopatologia , Atletas , Futebol Americano/lesões , Osteoartrite/epidemiologia , Qualidade de Vida , Adulto , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite/fisiopatologia , Medidas de Resultados Relatados pelo Paciente , Prevalência , Aposentadoria , Inquéritos e Questionários
10.
Inj Epidemiol ; 5(1): 26, 2018 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-29911282

RESUMO

BACKGROUND: As a consequence of severe knee injuries, knee osteoarthritis (OA) seems prevalent in retired professional footballers. However, some epidemiological data remain missing, for instance whether knee OA is also prevalent in current professional footballers, whether knee OA is associated with knee injuries and surgeries, and whether knee OA leads to a lower level of functioning. Therefore, three research questions were answered: (i) what is the prevalence of knee osteoarthritis (OA) among current and retired professional footballers? (ii) is severe knee injury or knee surgery associated with knee OA among current and retired professional footballers? (iii) what are the consequences of knee OA on physical knee function among current and retired professional footballers? METHODS: An observational study based on a cross-sectional design by means of questionnaires was conducted. Participants were current and retired professional footballers recruited by the World Players' Union (FIFPro). Information about severe knee injury and knee OA was gathered (medical record or team doctor), while physical knee function was assessed through a validated scale. RESULTS: A total of 1360 participants (964 current and 396 retired professional footballers) were enrolled in the study (response rate of 54%). Prevalence of knee OA was 13% among current players and 28% among retired players (p < 0.01), being higher among older players. Current and retired professional footballers were nearly twice as likely to suffer from knee OA by every additional severe knee injury and by every additional knee surgery (risk ratio: 1.72-1.96; p < 0.01). Current and retired professional footballers with knee OA reported a lower level of physical knee function than current and retired players without OA (p < 0.01), their physical knee function being also lower than reference values (adult population, young athletic population and amateur footballers). CONCLUSION: The prevalence of knee OA was higher among retired than among current professional footballers and reached up to 40%, leading to negative consequences for their physical knee function. Current and retired professional footballers were nearly twice as likely to suffer from knee OA by every additional severe knee injury and by every additional knee surgery incurred during their career. Management of knee OA should be prioritized among professional footballers, especially to prevent the worsening of the condition during their retirement years.

11.
Phys Sportsmed ; 46(4): 471-476, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-29527975

RESUMO

OBJECTIVE: The objective of the current study was to explore whether retired professional footballers suffering from lower extremity OA have a lower health-related quality of life than those without OA or current professional footballers. METHODS: An observational study based on a cross-sectional design by means of questionnaires was conducted. Participants were retired and current professional footballers recruited by the World Players' Union (FIFPro). Information about lower extremity OA (clinically diagnosed by a medical professional) was gathered, while health-related quality of life (Global Physical Health and Global Mental Health scores) was assessed through a validated scale. RESULTS: A total of 396 retired and 361 current professional footballers were included in the analyses (response rate of 54%). The group of retired professional footballers was on average 36 years old, and they had competed in professional football for 11 years (retired for 5 years). The group of current professional footballers was on average 25 years old, and they had been active in professional football for 7 years. Within the group of retired professional footballers, prevalence of lower extremity OA was 33%. Both Global Physical Health and Global Mental Health scores among retired professional footballers with lower extremity OA were significantly lower than among retired players without OA and current players, but these scores were nearly similar to the norm for the general population (regardless the presence of OA or not). CONCLUSIONS: Health-related quality of life among retired professional footballers with lower extremity OA was significantly lower than among retired players without OA and current players but nearly similar to the norm for the general population (regardless the presence of OA or not). A rational recommendation is that a support measure such as the After Career Consultation should be introduced among retired professional footballers in order to empower their sustainable health and quality of life, focussing especially on the prevention of the occurrence or worsening of lower extremity OA.


Assuntos
Extremidade Inferior/fisiopatologia , Osteoartrite/epidemiologia , Qualidade de Vida , Aposentadoria , Futebol , Adulto , Atletas , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Inquéritos e Questionários
13.
Phys Sportsmed ; 45(4): 443-449, 2017 11.
Artigo em Inglês | MEDLINE | ID: mdl-28870119

RESUMO

OBJECTIVE: Recent reports suggest that exposure to repetitive concussions in sports is associated with an increased risk of symptoms of distress, anxiety and depression, sleep disturbance or substance abuse/dependence (typically referred as symptoms of common mental disorders[CMD]) and of later development of neurodegenerative disease, in particular chronic traumatic encephalopathy (CTE). The primary aim of this study was to explore the relationship between sports career-related concussions and the subsequent occurrence of symptoms of CMD among former male professional athletes retired from football (soccer), ice hockey and rugby (union). METHODS: Cross-sectional analyses were performed on baseline electronic questionnaires from three prospective cohort studies among former male professional athletes retired from football (soccer), ice hockey and rugby (union). The number of confirmed concussions was examined through a single question, while symptoms of distress, anxiety and depression, sleep disturbance and adverse alcohol use were assessed using validated questionnaires. RESULTS: From 1,957 former professional athletes contacted, a total of 576 (29%) completed the questionnaire. Of these, 23% had not incurred a concussion during their career, 34% had two or three, 18% four or five, and 11% six or more concussions. The number of sports career-related concussions was a predictor for all outcome measures (ß = 0.072-0.109; P ≤ 0.040). Specifically, former professional athletes who reported a history of four or five concussions were approximately 1.5 times more likely to report symptoms of CMD, rising to a two- to five-fold increase in those reporting a history of six or more sports career-related concussions. CONCLUSIONS: These data demonstrate an association between exposure to sports concussion and subsequent risk of symptoms of CMD in former professional athletes across a range of contact sports. Further work to explore the association between sports concussion and symptoms of CMD is required; in the meanwhile, strategies for effective risk reduction and improved management appear indicated.


Assuntos
Atletas/psicologia , Concussão Encefálica/complicações , Futebol Americano/psicologia , Hóquei/psicologia , Transtornos Mentais/etiologia , Futebol/psicologia , Adulto , Transtornos Relacionados ao Uso de Álcool/epidemiologia , Transtornos Relacionados ao Uso de Álcool/etiologia , Ansiedade/epidemiologia , Ansiedade/etiologia , Transtornos de Ansiedade/epidemiologia , Transtornos de Ansiedade/etiologia , Atletas/estatística & dados numéricos , Concussão Encefálica/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Depressão/etiologia , Transtorno Depressivo/epidemiologia , Transtorno Depressivo/etiologia , Humanos , Masculino , Transtornos Mentais/epidemiologia , Estudos Prospectivos , Fatores de Risco , Transtornos do Sono-Vigília/epidemiologia , Transtornos do Sono-Vigília/etiologia , Inquéritos e Questionários
14.
Eur J Sport Sci ; 17(10): 1328-1334, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28961069

RESUMO

The aim of the study was twofold, namely (i) to determine the prevalence of symptoms of common mental disorders (CMDs) among current and retired professional football and handball players and (ii) to explore the relationship of psychosocial stressors with the outcome measures under study. A total of 1155 players were enrolled in an observational study based on a cross-sectional design. Questionnaires based on validated scales were set up and distributed among current and retired professional football and handball players by the Danish football and handball players' union. In professional football, the highest prevalence (4 weeks) of symptoms of CMDs was 18% and 19% for anxiety/depression among current and retired players, respectively. In professional handball, the highest prevalence (4 weeks) of symptoms of CMDs was 26% and 16% for anxiety/depression among current and retired players, respectively. For both the current and retired professional football and handball players, a higher number of severe injuries and recent adverse life events (LE) were related to the presence of symptoms of CMD. Players exposed to severe injuries and/or recent adverse LE were 20-50% times more likely to report symptoms of CMD. The results suggest that it is possible to recognize the population of professional athletes that are more likely to develop symptoms of CMD. This could create the opportunity to intervene preventively on athletes that suffered from severe injury and/or recent adverse LE that could lead to a faster and safer recovery and psychological readiness to return to play.


Assuntos
Atletas/psicologia , Transtornos Mentais/epidemiologia , Futebol , Adulto , Ansiedade/epidemiologia , Traumatismos em Atletas/psicologia , Estudos Transversais , Dinamarca , Depressão/epidemiologia , Feminino , Humanos , Acontecimentos que Mudam a Vida , Masculino , Prevalência , Aposentadoria , Estresse Psicológico/epidemiologia , Inquéritos e Questionários , Adulto Jovem
15.
Transplantation ; 82(4): 516-26, 2006 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-16926596

RESUMO

BACKGROUND: Reconstruction of skeletal muscle tissue is hampered by the lack of availability of functional substitution of the tissue. METHODS: Embryonic stem (ES) cells were transfected with the insulin-like growth factor (IGF) II gene and were selected with G418. The resultant cell clones were analyzed regarding their myogenic differentiation in vitro and in vivo. RESULTS: The cells expressed early and late myogenic differentiation markers, including myoD, myogenin, and dystrophin in vitro. They had phosphorylated Akt within the cells, suggesting their activation by the secreted IGFII. Transplantation of the cells to injured anterior tibial muscle of mice significantly improved their motor functions compared to injured mice transplanted with undifferentiated ES cells and injured mice given vehicle alone. The transfected cells adapted to the injured muscle, formed myofibers positive for dystrophin and negative for MyoD and myogenin. Trichrome staining and toluidine blue staining support myofiber formation in vivo. The enzymatic activity of acetylcholine esterase suggested the functional activity of the regenerated motor units. The evoked electromyogram of anterior tibial muscle transplanted with the transfected cells showed significantly higher potentials compared to that transplanted with undifferentiated ES cells and that injected with phosphate-buffered saline (control injury). Electron microscopic examination confirmed the myofiber formation in the cells in vivo. CONCLUSIONS: Transfection of IGFII gene into ES cells may be applicable for transplantation therapy of muscle damage due to injury and myopathies.


Assuntos
Embrião de Mamíferos/citologia , Terapia Genética , Fator de Crescimento Insulin-Like II/genética , Células Musculares/citologia , Músculo Esquelético/lesões , Transplante de Células-Tronco , Adaptação Fisiológica , Animais , Diferenciação Celular , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Regeneração , Transfecção
16.
Int J Mol Med ; 18(1): 113-7, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16786162

RESUMO

Synoviolin is an endoplasmic reticulum (ER)-resident E3 ubiquitin ligase which plays a critical role in ER-associated degradation (ERAD). We found that Synoviolin is a novel causative factor for rheumatoid arthritis (RA), which is especially up-regulated in proliferating synovial cells in the disease. We attempted to examine the role of Synoviolin in ER stress-induced apoptosis and proliferation of synovial cells. RA synovial cells (RSCs) were refractory to ER stress-induced apoptosis compared with HEK293 or HeLa cells. RSCs were also more resistant to the apoptosis than synovial cells from osteoarthritis patients, significantly. Down-regulation of Synoviolin by siRNA increased the susceptibility to ER stress-induced apoptosis in RSCs. Knock-down of Synoviolin by siRNA did not only induce apoptosis of RSCs but also inhibited their proliferation in vitro. These data suggest that RSCs are extraordinarily refractory to ER stress-induced apoptosis, and we termed this special property 'hyper-ERAD'. Since Synoviolin is overexpressed in RSCs, and is known to play a critical role in the ERAD system as E3 ubiquitin ligase, hyper-ERAD is likely to present in these cells. Subsequently, the hyper-ERAD may cause synovial hyperplasia through its anti-apoptotic effect in RA. Further analyses are necessary to address this point, however, resistance to ER stress-induced apoptosis, or hyper-ERAD is a noteworthy new cellular characteristic of RSCs.


Assuntos
Artrite Reumatoide/metabolismo , Retículo Endoplasmático/metabolismo , Membrana Sinovial/metabolismo , Ubiquitina-Proteína Ligases/metabolismo , Apoptose/fisiologia , Artrite Reumatoide/patologia , Artrite Reumatoide/fisiopatologia , Proliferação de Células , Células Cultivadas , Células HeLa , Humanos , RNA Interferente Pequeno/genética , Membrana Sinovial/patologia , Membrana Sinovial/fisiopatologia , Ubiquitina-Proteína Ligases/genética
17.
Asian J Sports Med ; 7(2): e28447, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27625749

RESUMO

BACKGROUND: Mental disorders have become a topic of increasing interest in research due to their serious consequences for quality of life and functioning. OBJECTIVES: The objective of this study was to explore the relationship of level of education, employment status and working hours with symptoms of common mental disorders (distress, anxiety/depression, sleep disturbance, adverse alcohol behaviour, smoking, adverse nutritional behaviour) among current and retired professional footballers. MATERIALS AND METHODS: Cross-sectional analyses were conducted on baseline questionnaires from an ongoing prospective cohort study among current and retired professional footballers. Based on validated scales, an electronic questionnaire was set up and distributed by players' unions in 11 countries across three continents. RESULTS: A total of 607 current professional footballers (mean age of 27 years) and 219 retired professional footballers (mean age of 35 years) were involved in the study. Among retired professional footballers, statistically significant negative correlations were found between employment status and symptoms of distress and anxiety/depression (P < 0.05), as well as between number of working hours and symptoms of anxiety/depression (P < 0.05). No other statistically significant associations were found among retired players. Among current professional footballers, level of education was not associated with symptoms of common mental disorders. CONCLUSIONS: Among retired professional footballers, employment status as well as a higher number of working hours was weakly correlated to symptoms of distress and anxiety/depression. Combining a football career with sustainable attention for educational and career planning might be important and of high priority.

18.
J Sports Med Phys Fitness ; 56(5): 648-54, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-27285354

RESUMO

BACKGROUND: The objective of this study was to determine the prevalence of symptoms related to mental disorders (distress, anxiety/depression, sleep disturbance, adverse alcohol behavior, adverse smoking behavior, adverse nutrition behavior) among retired professional footballers, and to explore their associations with stressors, i.e. determinants such as severe injury, surgery, life events and career dissatisfaction. METHODS: Cross-sectional analyses were conducted on baseline questionnaires from an ongoing prospective cohort study among retired male professional footballers. Based on validated questionnaires to assess both stressors and symptoms related to mental disorders, an electronic questionnaire was set up and distributed by players' unions in 11 countries across three continents. RESULTS: Prevalence of symptoms related to mental disorders among 219 retired professional footballers ranged from 11% for adverse smoking behavior and 18% for distress, to 35% for anxiety/depression and 65% for adverse nutrition behavior. Especially life events that occurred in the previous six months was positively associated with distress (OR=1.3; 95% CI: 1.0-1.6), anxiety/depression (OR=1.6; 95% CI: 1.2-2.1), sleeping disturbance (OR=1.3; 95% CI: 1.1-1.7) and adverse nutrition behavior (OR=1.4; 95% CI: 1.0-1.8). CONCLUSIONS: A high prevalence of symptoms related to mental disorders was found among retired professional footballers, confirming a previous study in a similar study population. Relationships were established between symptoms of mental disorders and severe injuries, recently occurred life events, and career dissatisfaction.


Assuntos
Atletas/psicologia , Futebol Americano , Transtornos Mentais/epidemiologia , Transtornos Mentais/etiologia , Transtornos Mentais/fisiopatologia , Aposentadoria/psicologia , Adulto , Consumo de Bebidas Alcoólicas/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Prevalência , Estudos Prospectivos , Fumar/epidemiologia , Inquéritos e Questionários
19.
Clin Spine Surg ; 29(6): E303-8, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-24136054

RESUMO

STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate clinical and radiographic outcome of posterior decompression and occipito-cervical/thoracic (OCT) fusion in patients with irreducible atlantoaxial kyphosis (IAK). SUMMARY OF BACKGROUND DATA: Posterior OCT fusion is an effective surgical procedure for treating IAK in the elderly. However, it is unclear whether correction can be obtained by the strong corrective force provided by implants, even in patients in whom reduction cannot be obtained preoperatively. There are no reports of improvement in patients in whom correction could not be achieved by a rigid system. METHODS: Twenty-five patients with IAK with mild vertical subluxation due to rheumatoid arthritis and 3 patients with IAK due to os odontoideum were treated with fossa magnum decompression, C1 laminectomy and OCT fusion. RESULTS: Mean follow-up period was 4.2 years. Preoperative and postoperative neurological findings revealed improvement by 1 or more grades in 18 of 28 (64.2%) patients. The parameters of spinal alignment, sagittal spinal cord alignment, and basilar invagination were evaluated on radiographs. No significant difference between preoperative and postoperative status was seen for the clivo-axial angle, occipito-upper cervical angle, atlantodental interval, or occipito-cervical 2 angle, whereas significant improvement was seen in the cervico-medullary and dorsal CM angles (both P<0.05). No significant postoperative change in the vertical direction was seen for any of the parameters. Width of the spinal cord at the C1 level was significantly increased postoperatively, with a significant expansion of the cerebral spinal fluid space at the same level (P<0.05). CONCLUSIONS: Posterior decompression with fusion for the treatment of IAK in the elderly did not produce significant change in spinal alignment, but did significantly improve spinal cord alignment and local spinal cord compression at the C1 level, achieving satisfactory clinical outcomes.


Assuntos
Articulação Atlantoaxial/cirurgia , Vértebras Cervicais/cirurgia , Descompressão Cirúrgica/métodos , Cifose/cirurgia , Fusão Vertebral/métodos , Idoso , Articulação Atlantoaxial/anormalidades , Feminino , Humanos , Estudos Longitudinais , Imageamento por Ressonância Magnética , Masculino , Cervicalgia/etiologia , Cervicalgia/cirurgia , Estudos Retrospectivos , Resultado do Tratamento
20.
J Hum Kinet ; 49: 277-86, 2015 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-26925182

RESUMO

To present time, scientific knowledge about symptoms of common mental disorders and adverse health behaviours among professional soccer players is lacking. Consequently, the aim of the study was to determine the prevalence of symptoms of common mental disorders (distress, anxiety/depression, sleep disturbance) and adverse health behaviours (adverse alcohol behaviour, smoking, adverse nutrition behaviour) among professional soccer players, and to explore their associations with potential stressors (severe injury, surgery, life events and career dissatisfaction). Cross-sectional analyses were conducted on baseline questionnaires from an ongoing prospective cohort study among male professional players. Using validated questionnaires to assess symptoms of common mental disorders and adverse health behaviours as well as stressors, an electronic questionnaire was set up and distributed by players' unions in 11 countries from three continents. Prevalence of symptoms of common mental disorders and adverse health behaviours among professional soccer players ranged from 4% for smoking and 9% for adverse alcohol behaviour to 38% for anxiety/depression and 58% for adverse nutrition behaviour. Significant associations were found for a higher number of severe injuries with distress, anxiety/depression, sleeping disturbance and adverse alcohol behaviour, an increased number of life events with distress, sleeping disturbance, adverse alcohol behaviour and smoking, as well as an elevated level of career dissatisfaction with distress, anxiety/depression and adverse nutrition behaviour. Statistically significant correlations (p<0.01) were found for severe injuries and career dissatisfaction with most symptoms of common mental disorders. High prevalence of symptoms of common mental disorders and adverse health behaviours was found among professional players, confirming a previous pilot-study in a similar study population.

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