Detalhe da pesquisa
1.
C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.
J Virol
; 90(5): 2180-94, 2015 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26581995
2.
A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV.
Antimicrob Agents Chemother
; 58(7): 3679-88, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752271
3.
Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1.
J Virol
; 86(24): 13384-96, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23015723
4.
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.
Sci Adv
; 9(28): eadg2955, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37436982
5.
Loss of protease dimerization inhibition activity of darunavir is associated with the acquisition of resistance to darunavir by HIV-1.
J Virol
; 85(19): 10079-89, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813613
6.
Non-cleavage site gag mutations in amprenavir-resistant human immunodeficiency virus type 1 (HIV-1) predispose HIV-1 to rapid acquisition of amprenavir resistance but delay development of resistance to other protease inhibitors.
J Virol
; 83(7): 3059-68, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19176623
7.
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity.
Sci Rep
; 10(1): 10664, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32606378
8.
Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.
mBio
; 9(2)2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29511083
9.
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.
Elife
; 62017 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29039736