Focal Segmental Membranoproliferative Glomerulonephritis: A Histological Variant of Denys-Drash Syndrome.

Introduction: Denys-Drash Syndrome (DDS) consists of a triad of pseudohermaphroditism, Wilms'tumor and nephropathy. This condition may manifest as a complete triad or in an incomplete form; with either one or a combination of the above features. The characteristic glomerular abnormality in DDS is diffuse mesangial sclerosis (DMS).Case report: We report two cases of DDS with focal membranoproliferative glomerulonephritis (MPGN). Both of our cases were males with ambiguous genitalia. They had a similar heterozygous germline mutation in exon 9 of WT1, c.1180C>T, p.R394W; a known mutation hotspot for DDS. Case 1 had nephropathy at the age of 4 years and Case 2 at 2.5 years with different rates of progression to end-stage renal failure. Conclusion: Our findings, in combination with other reports, illustrate the clinicopathological heterogeneity of DDS. There are no universal recommendations for optimal management of patients with DDS due to the inability to accurately predict affected individuals' progress.

Study on the effect of COVID - 19 pandemic on the savings and investment pattern of the manufacturing sector.

As a consequence of Corona Virus unroll; humans faced uncertainty in income and changes in lifestyle. Due to lockdown, the spending attitude changed, as there was no way to have outings, expensive purchases like gold, real estate, car, etc. Most of the decisions are based on the circumstances faced. The circumstances are like walls, putting a limit around us. Behavioural Finance shows the financial activity of an individual based on his or her mental stability. In this paper, the savings and investment decisions before and after the COVID - 19 pandemic of the people related to the manufacturing sector in Tamil Nadu are observed by a survey. A study was made on circumstances created by COVID - 19 pandemic which brought change in savings behaviour and investment behaviour of individuals in manufacturing sector. An analysis was made based on the survey conducted to know the impression of the pandemic on manufacturing sector peoples' financial attitudes in Tamil Nadu (TN). The participants belonged to the working community of manufacturing sector. The association between the circumstances formed by corona virus and change in savings and investment options of the people related to the manufacturing sector in Tamil Nadu was studied. There is association between the actions undertaken by the Government (like lockdown and travel restrictions) and person's earnings, directly impacted savings and investment pattern of the individuals in manufacturing sector.

An exclusive hand protection device made of fused deposition modelling process using poly (lactic acid) polymer.

The world has been hit hardest by a type of Severe Acute Respiratory Syndrome (SARS) virus called corona. This vulnerability did not leave all the superpowers in the world. The virus, is spread through coughs and sneezes. It is also spread by touching objects or parts of an infected person. For this reason, it is considered an infectious disease. It is very difficult to protect ourselves from such a contagious disease. But the World Health Organization (WHO) says there are certain guidelines to follow. The first way is to prevent the spread of COVID-19 social infection by adhering to social spaces (i.e. 2 m intervals). Second, we can protect ourselves by using appropriate safety equipment. We can also protect ourselves from the COVID-19 virus by using sanitizers or soaps. So this study focuses on a 3D-printed hand protection device for COVID- 19 infection prevention. The design, fabrication, and testing of the gadget were all successful. Thus, a low-cost and efficient device made by eco-friendly Poly Lactic Acid (PLA) polymer material and may be utilized to operate some potentially susceptible and highly infectious surfaces in a variety of public areas, where touching and using particular components is common and frequent (eg door handles, electrical switches, ATM machines).