Detalhe da pesquisa
1.
Thyclotides, tetrahydrofuran-modified peptide nucleic acids that efficiently penetrate cells and inhibit microRNA-21.
Nucleic Acids Res
; 50(19): 10839-10856, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36215040
2.
Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.
Nucleic Acids Res
; 49(2): 713-725, 2021 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33406227
3.
Cyclopentane peptide nucleic acid: Gold nanoparticle conjugates for the detection of nucleic acids in a microfluidic format.
Biopolymers
; 113(3): e23481, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34812507
4.
An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes.
J Immunol
; 204(12): 3315-3328, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32393514
5.
Allosteric modulation of ß-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice.
Proc Natl Acad Sci U S A
; 116(37): 18684-18690, 2019 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31451647
6.
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
J Biol Chem
; 294(46): 17654-17668, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31481464
7.
PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer.
Molecules
; 25(4)2020 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32059456
8.
A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.
J Biol Chem
; 293(21): 7993-8008, 2018 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29602904
9.
Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.
J Am Chem Soc
; 141(20): 8327-8338, 2019 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31042030
10.
Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity.
Chemistry
; 24(38): 9485-9489, 2018 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653024
11.
Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy.
Angew Chem Int Ed Engl
; 57(10): 2687-2691, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29345807
12.
Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes.
Bioorg Med Chem Lett
; 25(21): 4757-4760, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26259805
13.
Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects.
J Am Chem Soc
; 136(35): 12296-303, 2014 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25116377
14.
PPG peptide nucleic acids that promote DNA guanine quadruplexes.
Chembiochem
; 15(13): 1887-90, 2014 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25044379
15.
A Biotinylated cpFIT-PNA Platform for the Facile Detection of Drug Resistance to Artemisinin in Plasmodium falciparum.
ACS Sens
; 9(3): 1458-1464, 2024 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38446423
16.
Prodrug Strategy Extends the Use of Anti-HIV Sulfanylbenzamides for Application In Vivo.
ACS Pharmacol Transl Sci
; 7(1): 259-273, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38250006
17.
Cyclopentane-peptide nucleic acids for qualitative, quantitative, and repetitive detection of nucleic acids.
Anal Chem
; 85(1): 251-7, 2013 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23214925
18.
Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.
Bioorg Med Chem Lett
; 23(20): 5689-93, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24012122
19.
Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.
Bioorg Med Chem
; 21(14): 4027-33, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23182216
20.
Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region.
Nucleic Acids Res
; 39(16): 7114-23, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21593130