Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 61
Filtrar
1.
Gynecol Endocrinol ; 28(10): 767-9, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22397585

RESUMO

OBJECTIVE: This study evaluating the lipid profile in women in post menopause using the hormone therapy (HT) with implants of estradiol and testosterone. METHOD: One year prospective cohort with 122 patients separated in group 1, not using HT, group 2 starting the use of HT, and group 3 with prior use of implants of estradiol and testosterone. All patients performed serum dosages of total cholesterol, HDL and triglycerides, in the beginning of the study and after 1 year. DISCUSSION: The use of E and T implants showed some statistically significant decrease in TC at the beginning of the HT and some decrease in LDL in the group using HT. In the group without HT there was no difference in lipid profile.


Assuntos
Androgênios/uso terapêutico , Estradiol/uso terapêutico , Terapia de Reposição de Estrogênios/métodos , Hiperlipidemias/prevenção & controle , Pós-Menopausa/sangue , Testosterona/uso terapêutico , Adulto , Idoso , Androgênios/administração & dosagem , Brasil/epidemiologia , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/prevenção & controle , Estudos de Coortes , Implantes de Medicamento , Estradiol/administração & dosagem , Terapia de Reposição de Estrogênios/efeitos adversos , Feminino , Humanos , Lipídeos/sangue , Pessoa de Meia-Idade , Estudos Prospectivos , Risco , Testosterona/administração & dosagem , Fatores de Tempo
2.
Gynecol Endocrinol ; 27(2): 96-100, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20504104

RESUMO

OBJECTIVE: To assess bone mineral density (BMD) in postmenopausal women using estradiol and testosterone hormonal implants comparing to that of patients without hormonal therapy. DESIGN OF THE STUDY: Sixty-one patients were followed in prospective cohort study separated in Group 1, 34 women using implants and Group 2, 27 women without implants and BMD assessment through Dual energy X-ray absorptiometry was conducted in the beginning of follow-up and after 1 year. RESULTS: The average lumbar spine BMD in Group 1 was 1.123 ± 0.16 kg/m(2) and 1.144 ± 0.18 kg/m(2) after 1 year, p=0.39 and femur BMD was 0.922 ± 0.16 kg/m(2) and 0.957 ± 0.12 kg/m(2) after 1 year of treatment, p=0.076. In Group 2, the initial lumbar spine BMD average was 1.064 ± 0.2 kg/m(2) and after 1 year, 1.001 ± 0.23 kg/m(2), p=0.112 and femur BMD changed from 0.928 ± 0.14 kg/m(2) to 0.881 ± 0.15 kg/m(2) after 1 year, p=0.046. CONCLUSION: BMD variance between the groups in the period of 1 year showed that the combination of estradiol and testosterone promoted bone protection in post menopausal women.


Assuntos
Osso e Ossos/efeitos dos fármacos , Estradiol/administração & dosagem , Terapia de Reposição de Estrogênios/métodos , Osteoporose Pós-Menopausa/prevenção & controle , Testosterona/administração & dosagem , Adulto , Idoso , Densidade Óssea/efeitos dos fármacos , Citoproteção/efeitos dos fármacos , Implantes de Medicamento , Feminino , Fêmur/efeitos dos fármacos , Seguimentos , Humanos , Vértebras Lombares/efeitos dos fármacos , Pessoa de Meia-Idade , Osteoporose Pós-Menopausa/epidemiologia , Prevalência
3.
Arch Endocrinol Metab ; 65(3): 322-327, 2021 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-33939906

RESUMO

OBJECTIVE: Percutaneous ethanol injection (PEI) is an alternative to surgery for the treatment of thyroid nodules (TNs). However, size reductions of treated (TTNs) and untreated TN (UTNs) have not been compared. Volumetric reductions in TTNs with PEI were evaluated by comparing TTNs and UTNs in the same patient, and independent variables predicting good post-PEI outcomes were analyzed. METHODS: Overall, 282 patients with multinodular goiters were selected. Two nodules located in different lobes were compared for common disease behaviors. Overall, 150 nodules were selected from 75 patients (6 M: 69 F) with a mean age of 50.1 ± 17.4 years. This prospective nonrandomized intervention study prioritized treating TNs of greater volume or single hyperfunctioning TNs. A single observer experienced in PEI and an ultrasound specialist performed the interventions. RESULTS: TTNs (mean volume: 14.8 ± 16.2 mL) were reduced by 72.6 ± 27.3% of their initial volume, while UTNs increased by a mean of 365.7 ± 1.403.8% (p < 0.00001). The patients underwent a mean of 4.0 ± 3.1 outpatient PEI sessions without relevant complications. Logistic regression analysis showed that the magnitude of the PEI induced reduction was associated with the number of treatment sessions (p = 0.03, CI [1.1-38.2]) and not with ultrasonographic characteristics of the nodules. Each PEI session increased the rate of TN reduction by a factor of 6.7. CONCLUSION: PEI is a well-tolerated outpatient procedure that effectively reduces the volume of TNs and is noticeably superior to conservative treatment for all ultrasonographic classifications.


Assuntos
Nódulo da Glândula Tireoide , Adulto , Idoso , Etanol , Humanos , Pessoa de Meia-Idade , Estudos Prospectivos , Nódulo da Glândula Tireoide/diagnóstico por imagem , Nódulo da Glândula Tireoide/tratamento farmacológico , Resultado do Tratamento , Ultrassonografia
4.
Microbiol Res ; 231: 126353, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31707299

RESUMO

Cladosporium spp. is a cosmopolitan fungal genus. In the literature, it has been reported as a biological agent for controlling several plant diseases, but its mechanism of action has never been clarified. The present study aims to identify Cladosporium spp. based on the DNA phylogeny of nine isolates obtained from the phylloplane of rice and their potential antagonistic activity against the main fungal pathogens that affect rice crop. Nine isolates of Cladosporium spp. were identified based on DNA phylogeny, molecular and morphological characterization, and their antagonistic effects with the rice pathogens C. miyabeanus, M. oryzae, M. albescens and S. oryzae. Four isolates were selected to study lytic enzymes such as ß-1,3-glucanase, chitinase and protease, and only one isolate was selected for a conidial germination and appressoria formation assay. The nine isolates were identified as C. cladosporioides, C. tenuissimum and C. subuliforme. Four isolates, identified as C. cladosporioides, inhibited the mycelial growth of rice pathogens such as C1H (68.59%) of S. oryzae, C5 G (74.32%) of C. miyabeanus, C11 G (75.97%) of M. oryzae and C24 G (77.39%) of M. albescens. C24 G showed a high activity of lytic enzymes, was tested against C. miyabeanus and M. oryzae, and inhibited conidial germination and appressorium formation by more than 59.36%. The characterization of C. cladosporioides suggested this species as a potential bioagent for the management of several rice diseases, especially rice blast. This is the first time that a potential biological agent from the genus Cladosporium identified at the species level was isolated from the rice phylloplane, and some of its mechanisms of action were demonstrated, such as increasing lytic enzyme activity against rice pathogens.


Assuntos
Cladosporium , Folhas de Planta/microbiologia , Patologia Vegetal , Antibiose , Ascomicetos/crescimento & desenvolvimento , Agentes de Controle Biológico , Quitinases/metabolismo , Cladosporium/enzimologia , Cladosporium/genética , Cladosporium/isolamento & purificação , DNA Ribossômico , Fungos não Classificados/crescimento & desenvolvimento , Glicosídeo Hidrolases/metabolismo , Magnaporthe/crescimento & desenvolvimento , Micoses , Oryza/microbiologia , Peptídeo Hidrolases/metabolismo , Filogenia , Doenças das Plantas
5.
Environ Sci Pollut Res Int ; 25(14): 13676-13686, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29502259

RESUMO

Agriculture accounts for ~ 70% of all water use and the world population is increasing annually; soon more people will need to be fed, while also using less water. The use of plant-associated bacteria (PAB) is an eco-friendly alternative that can increase crop water use efficiency. This work aimed to study the effect of some PAB on increasing soybean tolerance to drought stress, the mechanisms of the drought tolerance process, and the effect of the PAB on promoting plant growth and on the biocontrol of Sclerotinia sclerotiorum. PAB were isolated from soybean rhizosphere and S. sclerotiorum sclerotia. The strains identified as UFGS1 (Bacillus subtilis), UFGS2 (Bacillus thuringiensis), UFGRB2 and UFGRB3 (Bacillus cereus) were selected on their ability to grow in media with reduced water activity. Soybean plants were inoculated with the PAB and evaluated for growth promotion, physiological and molecular parameters, after drought stress. Under drought stress, UFGS2 and UFGRB2 sustained potential quantum efficiency of PSII (Fv/Fm), while a decrease was found in the control plants. Moreover, UFGS2 and UFGRB3 maintained the photosynthetic rates in non-stressed conditions compared to the control. UFGS2-treated plants showed a higher stomatal conductance and higher transpiration than the control, after drought stress. Some PAB-treated plants also had other beneficial phenotypes, such as increases in fresh and dried biomass relative to the control. Differential gene expression analysis of genes involved in plant stress pathways shows changes in expression in PAB-treated plants. Results from this study suggest that PAB can mitigate drought stress in soybean and may improve water efficiency under certain conditions.


Assuntos
Bactérias/metabolismo , Glycine max/metabolismo , Fotossíntese/fisiologia , Bactérias/química , Biomassa , Secas , Desenvolvimento Vegetal , Rizosfera , Glycine max/química , Água/química , Água/metabolismo
6.
Obes Surg ; 17(6): 809-14, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17879582

RESUMO

BACKGROUND: Obesity is the most important risk factor for obstructive sleep apnea. It is estimated that 70% of sleep apnea patients are obese. In the morbidly obese, the prevalence may reach 80% in men and 50% in women. The aim of this study was to determine the prevalence and severity of sleep apnea in a group of morbidly obese patients, leading to bariatric surgery. METHODS: In a cross-sectional study developed in Bahia, northeastern Brazil. 108 patients (78 women and 30 men) from the Obesity Treatment and Surgery Center--"Núcleo de Tratamento e Cirurgia da Obesidade" underwent standard polysomnography. Patients with an apnea-hypopnea index (AHI) > or = 5 events/hour were considered apneic. RESULTS: Mean +/- SD for age and BMI were 37.1 +/- 10.2 years and 45.2 +/- 5.4 kg/m2, respectively. The calculated AHI ranged widely from 2.5 to 128.9 events/hour. Sleep apnea was detected in 93.6% of the sample, wherein 35.2% had mild, 30.6% moderate and 27.8% severe apnea. Oxyhemoglobin desaturation was directly related to the AHI and was more severe in men. CONCLUSION: There was a high frequency of sleep apnea in this group of morbidly obese patients, for whom it was very important to request polysomnography, thus enabling therapeutic management and prognostication.


Assuntos
Obesidade Mórbida/complicações , Síndromes da Apneia do Sono/epidemiologia , Adulto , Cirurgia Bariátrica , Gasometria , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Mórbida/sangue , Obesidade Mórbida/cirurgia , Polissonografia , Prevalência , Índice de Gravidade de Doença , Síndromes da Apneia do Sono/sangue
7.
Vasc Health Risk Manag ; 2(4): 465-75, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17323601

RESUMO

Despite numerous studies on women's cardiac health throughout the past decade, the number of female deaths caused by cardiovascular disease still rises and remains the leading cause of death in women in most areas of the world. Novel studies have demonstrated that cardiovascular disease, and more specifically coronary artery disease presentations in women, are different than those in men. In addition, pathology and pathophysiology of the disease present significant gender differences, which leads to difficulties concerning diagnosis, treatment and outcome of the female population. The reason for this disparity is all steps for female cardiovascular disease evaluation, treatment and prevention are not well elucidated; and an area for future research. This review brings together the most recent studies published in the field of coronary artery disease in women and points out new directions for future investigation on some of the important issues.


Assuntos
Doença da Artéria Coronariana , Saúde da Mulher , Doença Aguda , Doença da Artéria Coronariana/diagnóstico , Doença da Artéria Coronariana/etiologia , Doença da Artéria Coronariana/fisiopatologia , Doença da Artéria Coronariana/prevenção & controle , Doença da Artéria Coronariana/terapia , Feminino , Cardiopatias/diagnóstico , Cardiopatias/etiologia , Humanos , Masculino , Guias de Prática Clínica como Assunto , Fatores de Risco , Fatores Sexuais , Síndrome
8.
Arq Bras Endocrinol Metabol ; 50(1): 74-81, 2006 Feb.
Artigo em Português | MEDLINE | ID: mdl-16628278

RESUMO

Obstructive sleep apnea and hypopnea syndrome (OSAHS) has been the focus of extensive research because of its association with neurocognitive and cardiovascular complications. The aim of this study was to evaluate the frequency and association between OSAHS and the class of obesity, gender and age in outpatients referred to a sleep laboratory. We selected 1,595 patients, 71.7% male. Mean +/- SD age was 46.7 +/- 11.7 years, BMI was 28.1 +/- 5.1 kg/m2 and AIH was 13.9 +/- 15.5 events/ hour of sleep. The patients were considered apneic when the apnea-hypopnea index (AHI) was > 5 events/hour of sleep; OSAHS was present in: (1) 71.1% of men and 50.3% of women (p < 0.001); (2) in 45.3% of patients with normal BMI, in 64.3% of those overweighed and in 80% of obese (p < 0.001). According to age, 61.2% with age < 55 were apneic, as well as 78% of those with age > 55 years old (p < 0.001). We concluded that OSAHS was directly and strongly associated to the male gender, obesity class and to aging.


Assuntos
Obesidade/complicações , Síndromes da Apneia do Sono/etiologia , Adulto , Fatores Etários , Idoso , Índice de Massa Corporal , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polissonografia , Estudos Retrospectivos , Fatores de Risco , Índice de Gravidade de Doença , Fatores Sexuais , Síndromes da Apneia do Sono/diagnóstico
9.
Arq Bras Endocrinol Metabol ; 50(1): 97-104, 2006 Feb.
Artigo em Português | MEDLINE | ID: mdl-16628281

RESUMO

To verify the effectiveness of percutaneous ethanol injection (PEI) in the treatment of thyroid nodules (TN), we analyzed 86 TN from 77 patients before and after one or two sessions of PEI. The medians of the initial and final volumes were: 3.5 mL (range 0.3-82.7) and 1.8 mL (range 0-29.4). Seven percent of the nodules disappeared and the mean nodule size reduction was 52.6% (p< 0.0001). After ethanol injection, the median volume reduction was: 37.3% (range -39.0-82.6) for solid; 53.5% (14.6-88.0) for mostly solid; 58.0% (21.0-64.5) for mixed; 71.0% (18.8-100.0) for mostly cystic and 90.0% (45.9-100.0) for cystic lesions. Furthermore, we compared the variation of the greatest diameter of TN, without any treatment and after PEI, and found this difference statistically significant (p< 0.00001). Pain was the most common complication, although this was mostly described as moderate (27.6%). We conclude that PEI is an efficient and safe treatment option for benign TN.


Assuntos
Cistos/tratamento farmacológico , Etanol/administração & dosagem , Soluções Esclerosantes/administração & dosagem , Nódulo da Glândula Tireoide/tratamento farmacológico , Adulto , Cistos/diagnóstico por imagem , Feminino , Humanos , Injeções Intralesionais , Masculino , Nódulo da Glândula Tireoide/diagnóstico por imagem , Resultado do Tratamento , Ultrassonografia
10.
Rev. Ciênc. Méd. Biol. (Impr.) ; 20(2): 277-285, set 29, 2021. tab, fig
Artigo em Português | LILACS | ID: biblio-1354479

RESUMO

Introdução: a infecção crônica pelo vírus da hepatite C (HCV) e a obesidade podem induzir esteatose hepática e diabetes mellitus (DM). Objetivo: avaliar a prevalência de obesidade e de distúrbios metabólicos em pacientes com HCV; estudar a prevalência de HCV e os distúrbios metabólicos em pacientes obesos. Comparar o perfil glicêmico entre os grupos. Metodologia: estudo analítico, com pacientes acompanhados nos ambulatórios de Hepatite C e Obesidade. Variáveis analisadas: glicemia, hemoglobina glicada (A1C), esteatose hepática, HCV, estágio de fibrose hepática e dados sociodemográficos. Resultados: no ambulatório de obesidade 45 pacientes foram avaliados, dos quais 6,7% tinham hepatite C, 40% DM e 61-73% esteatose hepática. As médias das enzimas hepáticas (U/L) foram: AST 22,9; ALT 25,2; FAL 146,5 e GGT 63. Nos obesos com DM, 72,2% apresentavam A1C < 7%. A segunda amostra continha 159 portadores de HCV do ambulatório de hepatologia: 17,9% tinham obesidade, 18,9% DM e 27% esteatose hepática. As médias das enzimas hepáticas (U/L) consistiram em: AST 70,5; ALT 90,6; FAL 108,5 e GGT 131,7. Entre os diabéticos com HCV, 52% não apresentavam A1C < 7%. Conclusão: foi encontrada alta prevalência de hepatite C em pacientes com obesidade (6,7%) quando comparados com a população de Salvador (1,5-1,8%). Os distúrbios metabólicos foram mais frequentes entre obesos, porém os diabéticos com obesidade revelaram A1C menores do que os diabéticos com HCV, sugerindo, neste estudo, que pode existir interferência viral no controle glicídico. A esteatose hepática foi mais prevalente entre obesos.


Introduction: Hepatitis C virus infection (HCV) and Obesity can to induce hepatic steatosis and diabetes mellitus (DM). Objectives: to evaluate the prevalence of obesity and metabolic disorders in HCV viremic patients. To study the prevalence of hepatitis C and metabolic disorders in patients with obesity. To compare glycemic profile between the groups. Methods: analytical study, with patients followed up at hepatitis C and Obesity outpatient clinics patients. Variables studied: blood glucose, glycated hemoglobin (A1C), hepatic steatosis, HCV, hepatic fibrosis stage and sociodemographic data. Results: in Obesity clinic sample 45 patients were evaluated, 6,7% was hepatitis C, 40% DM and 61% -73% hepatic steatosis. Mean of liver enzymes levels (U/L) were: AST 22.9; ALT 25.2; FAL 146.5 and GGT 63. In obese with DM, 72.2% of them were able to maintain A1C < 7%. The second sample contained 159 HCV carriers at the hepatology clinic, 17,9% was Obesity, 18,9% DM and 27% hepatic steatosis. Averages of serum liver enzymes level (U/ L) were: AST 70.5; ALT 90.6; FAL 108.5 and GGT 131.7. Among diabetics with HCV, 52% are unable to maintain A1C < 7%. Conclusions: found high prevalence of hepatitis C in patients with obesity (6.7%) when compared to the population of Salvador (1.5%-1.8%). Metabolic disorders were more frequent in the obese group, but diabetics with obesity have lower A1C values than diabetics with HCV, suggesting, in this study, that there may be a viral interference with glycid control. Liver steatosis is more prevalent among obese people


Assuntos
Humanos , Masculino , Feminino , Comorbidade , Prevalência , Hepatite C , Diabetes Mellitus , Obesidade , Glicemia , Hemoglobinas Glicadas , Métodos de Análise Laboratorial e de Campo , Epidemiologia Descritiva , Fígado Gorduroso
11.
Environ Sci Pollut Res Int ; 23(21): 21554-21564, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27515526

RESUMO

An alternative method to control rice blast (Magnaporthe oryzae) is to include biological agent in the disease management strategy. The objective of this study was to assess the leaf blast-suppressing effects of rice phylloplane fungi. One Cladosporium sp. phylloplane fungus was shown to possess biocontrolling traits based on its morphological characteristics and an analysis of its 18S ribosomal DNA. Experiments aimed at determining the optimal time to apply the bioagent and the mechanisms involved in its rice blast-suppressing activities were performed under controlled greenhouse conditions. We used foliar spraying to apply the Cladosporium sp. 48 h prior to applying the pathogen, and we found that this increased the enzymatic activity. Furthermore, in vitro tests performed using isolate C24 showed that it possessed the ability to secrete endoxylanases and endoglucanases. When Cladosporium sp. was applied either prior to or simultaneous with the pathogen, we observed a significant increase in defence enzyme activity, and rice blast was suppressed by 84.0 and 78.6 %, respectively. However, some enzymes showed higher activity at 24 h while others did so at 48 h after the challenge inoculation. Cladosporium sp. is a biological agent that is capable of suppressing rice leaf blast by activating biochemical defence mechanisms in rice plants. It is highly adapted to natural field conditions and should be included in further studies aimed at developing strategies to support ecologically sustainable disease management and reduce environmental pollution by the judicious use of fungicidal sprays.


Assuntos
Agentes de Controle Biológico/farmacologia , Cladosporium/fisiologia , Magnaporthe/fisiologia , Oryza/microbiologia , Doenças das Plantas/prevenção & controle , Agentes de Controle Biológico/classificação , Oryza/imunologia , Doenças das Plantas/microbiologia , Imunidade Vegetal , Folhas de Planta/microbiologia
12.
Arch. endocrinol. metab. (Online) ; 65(3): 322-327, May-June 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1285159

RESUMO

ABSTRACT Objective: Percutaneous ethanol injection (PEI) is an alternative to surgery for the treatment of thyroid nodules (TNs). However, size reductions of treated (TTNs) and untreated TN (UTNs) have not been compared. Volumetric reductions in TTNs with PEI were evaluated by comparing TTNs and UTNs in the same patient, and independent variables predicting good post-PEI outcomes were analyzed. Materials and methods: Overall, 282 patients with multinodular goiters were selected. Two nodules located in different lobes were compared for common disease behaviors. Overall, 150 nodules were selected from 75 patients (6 M: 69 F) with a mean age of 50.1 ± 17.4 years. This prospective nonrandomized intervention study prioritized treating TNs of greater volume or single hyperfunctioning TNs. A single observer experienced in PEI and an ultrasound specialist performed the interventions. Results and discussion: TTNs (mean volume: 14.8 ± 16.2 mL) were reduced by 72.6 ± 27.3% of their initial volume, while UTNs increased by a mean of 365.7 ± 1.403.8% (p < 0.00001). The patients underwent a mean of 4.0 ± 3.1 outpatient PEI sessions without relevant complications. Logistic regression analysis showed that the magnitude of the PEI induced reduction was associated with the number of treatment sessions (p = 0.03, CI [1.1-38.2]) and not with ultrasonographic characteristics of the nodules. Each PEI session increased the rate of TN reduction by a factor of 6.7. Conclusions: PEI is a well-tolerated outpatient procedure that effectively reduces the volume of TNs and is noticeably superior to conservative treatment for all ultrasonographic classifications.


Assuntos
Humanos , Adulto , Idoso , Nódulo da Glândula Tireoide/tratamento farmacológico , Nódulo da Glândula Tireoide/diagnóstico por imagem , Estudos Prospectivos , Ultrassonografia , Resultado do Tratamento , Etanol , Pessoa de Meia-Idade
13.
Arq Bras Endocrinol Metabol ; 49(4): 557-62, 2005 Aug.
Artigo em Português | MEDLINE | ID: mdl-16358085

RESUMO

OBJECTIVE: To evaluate the correlation of gamma-glutamyl transferase (GGT) activity to the presence and number of abnormalities of the metabolic syndrome (MS). SUBJECT AND METHODS: We have studied 353 women consecutively admitted into the obesity outpatient unit, aged 39.0 +/- 11.4 years and body mass index 41.3 +/- 7.3 kg/m2. All patients were asymptomatic, had no history of alcohol abuse or liver disease. National Cholesterol Education Program--Adult Treatment Panel III criteria for diagnosing MS were applied. RESULTS: The frequency of the MS was 50.7% in the patients. The frequency of elevated GGT activity was higher in patients with MS than without it (32% versus 20%, p = 0.05). The average GGT concentration in patients with the MS was significantly higher than in non SM patients (52.8 +/- 42.3 U/L; Md: 40.0 versus 40.1 +/- 28.8 U/L; Md: 33.0, p = 0.0001). It was also higher in patients with each one abnormality of the MS, when compared to those without it. In patients with association of three abnormalities of the MS, the mean GGT activity was 51.0 +/- 39.2 U/L (Md: 36.0); in those with four, 50.8 +/- 50.4 U/L (Md: 40.5); and five, 64.8 +/- 32.3 U/L (Md: 61.0). There were positive correlations between GGT and glucose, triglycerides or blood pressure (systolic and diastolic). CONCLUSION: GGT activity was associated to the presence and the number of abnormalities of the MS, as well as to each one abnormality of the MS in obese women.


Assuntos
Síndrome Metabólica/enzimologia , Obesidade/complicações , gama-Glutamiltransferase/sangue , Adulto , Idoso , Biomarcadores/sangue , Feminino , Humanos , Hipertensão/complicações , Síndrome Metabólica/complicações , Síndrome Metabólica/diagnóstico , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Sensibilidade e Especificidade
14.
Radiol Bras ; 48(3): 148-53, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26185340

RESUMO

OBJECTIVE: To evaluate the association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC). MATERIALS AND METHODS: The patients were evaluated by ultrasonography-guided fine needle aspiration cytology. Typical cytopathological aspects and/or classical histopathological findings were taken into consideration in the diagnosis of HT, and only histopathological results were considered in the diagnosis of PTC. RESULTS: Among 1,049 patients with multi- or uninodular goiter (903 women and 146 men), 173 (16.5%) had cytopathological features of thyroiditis. Thirty-three (67.4%) out of the 49 operated patients had PTC, 9 (27.3%) of them with histopathological features of HT. Five (31.3%) out of the 16 patients with non-malignant disease also had HT. In the groups with HT, PTC, and PCT+HT, the female prevalence rate was 100%, 91.6%, and 77.8%, respectively. Mean age was 41.5, 43.3, and 48.5 years, respectively. No association was observed between the two diseases in the present study where HT occurred in 31.1% of the benign cases and in 27.3% of malignant cases (p = 0.8). CONCLUSION: In spite of the absence of association between HT and PCT, the possibility of malignancy in HT should always be considered because of the coexistence of the two diseases already reported in the literature.


OBJETIVO: Avaliar a associação entre tireoidite de Hashimoto (TH) e carcinoma papilífero da tireoide (CPT). MATERIAIS E MÉTODOS: Pacientes foram avaliados por punção aspirativa guiada pela ultrassonografia. Para TH consideraram-se aspectos característicos da citopatologia e/ou achados histopatológicos clássicos. O diagnóstico de CPT foi considerado apenas pela histopatologia. RESULTADOS: De 1.049 pacientes portadores de bócios uni-multinodulares (903 femininos e 146 masculinos), 173 (16,5%) tinham quadro citopatológico de tireoidite. Dos 49 pacientes operados, 33 (67,4%) revelaram CPT, dos quais 9 (27,3%) tinham a glândula com quadro histopatológico de TH. Dos 16 pacientes sem malignidade, 5 (31,3%) exibiam também TH. Nos grupos TH, CPT e CPT+TH, a proporção de acometimento do gênero feminino foi, respectivamente, 100%, 91,6% e 77,8%. A distribuição da média da idade (anos) nos três grupos foi 41,5, 43,3 e 48,5. Não houve associação entre as duas doenças, neste estudo, em que a TH esteve presente em 31,3% dos casos benignos e em 27,3% dos casos malignos (p = 0,8). CONCLUSÃO: Não houve associação entre TH e CPT, mas a possibilidade de malignidade em TH deve ser sempre lembrada em razão da concomitância das duas doenças, já revelada na literatura.

15.
Arq Bras Endocrinol Metabol ; 48(2): 276-81, 2004 Apr.
Artigo em Português | MEDLINE | ID: mdl-15640883

RESUMO

Long-term treatment of obese patients shows that the majority of them regains weight or has weight cycling (WC). We have studied the frequency of WC (weight lost and regain of at least 5% of initial weight, IW) in 218 obese women selected from a University Hospital with a follow-up of >12 months admitted between 1992 and 2000. Patients with psychiatric, infectious or chronic disease (except metabolic syndrome), pregnancy, or using glucocorticoids were excluded. Mean age was 38+/-10 years (range 18 to 68) and the mean BMI was 41.0+/-6.6 kg/m2 (range 30 to 76). All were treated with a hypocaloric diet and increased physical activity. Anti-obesity medications were used in 61% of them for short periods of time. In the follow-up of 28+/-16 months (range 12 to 92 mo, median 23 mo), WC was observed in 62/218 (28.4%) of them and 53 had weight lost followed by weight regain. In the weight-cyclers, 59.1% of patients regained weight before the first year of treatment. WC was associated with alcohol consumption higher than 60 g/week, (RR 2.4; 95% CI= 1.2-4.7) but not with obesity class, smoking or smoke cessation. We conclude that WC is highly frequent and alcohol consumption is a predictive risk factor.


Assuntos
Peso Corporal , Obesidade/fisiopatologia , Obesidade/terapia , Adolescente , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos
16.
J Endod ; 40(1): 16-27, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24331985

RESUMO

INTRODUCTION: This study aimed to analyze cases referred from a reference service in oral pathology that were initially misdiagnosed as periapical lesions of endodontic origin and to perform a review of the literature regarding lesions located in the apical area of teeth with a nonendodontic source. METHODS: A survey was made of clinical cases derived from the service of oral pathology from 2002 to 2012. The pertinent literature was also reviewed using ScienceDirect and PubMed databases. The lesions were grouped into benign lesions mimicking endodontic periapical lesions (BLMEPLs), malignant lesions mimicking endodontic periapical lesions (MLMEPLs), and Stafne bone cavities. The clinical presentations were divided into lesions with swelling without pain, lesions with swelling and pain, and lesions without swelling but presenting with pain. RESULTS: The results showed that 66% (37/56) of cases represented benign lesions, 29% (16/56) malignant lesions, and 5% (3/56) Stafne bone cavities. The most commonly reported BLMEPLs were ameloblastomas (21%) followed by nasopalatine duct cysts (13.5%). The most frequently cited MLMEPLs were metastatic injuries (31.5%) followed by carcinomas (25%). The main clinical presentation of BLMEPLs was pain, whereas that of MLMEPLs was swelling associated with pain; Stafne bone cavities displayed particular clinical findings. CONCLUSIONS: Clinical and radiologic aspects as well as the analysis of the patients' medical history, pulp vitality tests, and aspiration are essential tools for developing a correct diagnosis of periapical lesions of endodontic origin. However, if the instruments mentioned earlier indicate a lesion of nonendodontic origin, a biopsy and subsequent histopathological analysis are mandatory.


Assuntos
Erros de Diagnóstico , Periodontite Periapical/diagnóstico , Adolescente , Adulto , Ameloblastoma/diagnóstico , Carcinoma Mucoepidermoide/diagnóstico , Cementoma/diagnóstico , Doenças da Polpa Dentária/diagnóstico , Feminino , Humanos , Cistos Maxilomandibulares/diagnóstico , Doenças Maxilomandibulares/diagnóstico , Neoplasias Maxilomandibulares/diagnóstico , Masculino , Pessoa de Meia-Idade , Mixoma/diagnóstico , Cistos não Odontogênicos/diagnóstico , Tumores Odontogênicos/diagnóstico , Granuloma Periapical/diagnóstico
18.
Eng. sanit. ambient ; 23(1): 77-90, jan.-fev. 2018. tab, graf
Artigo em Português | LILACS | ID: biblio-891620

RESUMO

RESUMO As camadas de cobertura de aterros sanitários são construídas para impedir a saída de gases para a atmosfera e a entrada de líquidos no interior do aterro, minimizando os impactos no meio ambiente. Este trabalho avaliou, por meio de ensaios de colunas de solos em laboratório, o desempenho de duas camadas de cobertura, compreendendo o comportamento dos solos em função das emissões de metano (CH4) e da infiltração de água em seu interior. Foram utilizadas duas configurações de camada de solos: Coluna 1, camada convencional com solo com espessura 0,60 m e grau de compactação de 80%; e Coluna 2, camada oxidativa, com espessura de 0,30 m de solo com grau de compactação de 80%, sobreposta por uma camada de 0,30 m de solo misturado com produto compostado na proporção de 1:1 em volume com grau de compactação de 76%. Após a confecção das colunas (dimensões úteis de 0,60 m de altura e 0,15 m de diâmetro), foi injetado CH4 em sua parte inferior com concentração de 100% na vazão de 0,5 L/h (8,3 mL/min ou 486 g/m2.dia) para se avaliar a redução das emissões. Posteriormente, foi simulada chuva de 40 mm - sendo 30 mm em 1 dia e 10 mm 3 dias após a primeira simulação - e avaliada a infiltração da água e as emissões de CH4 nas colunas. Os resultados obtidos indicam que as duas configurações de camadas de cobertura apresentaram resultados satisfatórios, diminuindo o volume de líquidos para o interior do aterro e minimizando as emissões de CH4 para a atmosfera. Observou-se que a Coluna 2 (0,30 m de solo + 0,30 m de solo + produto compostado) se mostrou mais eficiente tanto na redução de emissões como na capacidade de retenção de água em relação à Coluna 1 (0,60 m de solo), sugerindo que camadas oxidativas podem se tornar uma alternativa tecnológica para regiões onde exista escassez de solos argilosos.


ABSTRACT Landfill cover layers are built to prevent the release of gases into the atmosphere and the inflow of liquids into the landfill, minimizing impacts on the environment. This study evaluated, through the testing of soil columns in the laboratory, the performance of two cover layers, comprehending the behavior of the soils as a function of methane emissions and liquid flows in its interior. Two configurations were used in the soil layer: Column 1, conventional layer with compacted soil of 0.60 m thickness and 80% degree of compaction; and Column 2, oxidative layer with 0.30 m thickness of soil and 80% degree of compaction, stuck by a layer of 0.30 m of mixed soil with composted product in the volume ratio of 1:1 with 76% degree of compaction. After the confection of the columns (0.60 m in height and 0.15 m in diameter), methane gas was injected into the inferior part of the columns with a concentration of 100% at a flow rate of 0.5 L/h (8.3 mL/min or 486 g/m2.day) to evaluate the emission reduction. Subsequently, a rain of 40 mm was simulated - being 30 mm in one day and 10 mm three days after the first simulation -, and both the methane emissions and the infiltration of water in the columns were evaluated. The obtained results indicate that the two column configurations of landfill cover layers presented satisfactory results, reducing the volume of liquids into the landfill and minimizing the methane emissions into the atmosphere. It is observed that Column 2 (0.30 m of soil + 0.30 m of soil + composted product) was more efficient in the reduction of emissions, as well as in the retention capacity of water in relation to Column 1 (0.60 m of soil), suggesting that oxidative layers can become a technological alternative for regions where there is scarcity of clay soils.

19.
REVISA (Online) ; 7(1): 65-75, 2018.
Artigo em Português | LILACS | ID: biblio-1096883

RESUMO

Avaliou-se o transcorrer da construção da identidade de uma criança afrodescendente nas Escolas Brasileiras. Trata-se de uma revisão da literatura científica realizada em abril de 2017 na Biblioteca Virtual em Educação (BVE), Periódicos Capes e o Google Acadêmico por meio dos descritores: Identidade, criança, educação infantil, racista, professor. O estudo fora dividido em três vertentes: 1. A identidade do afrodescendente; 2. Desenvolvimento da Identidade da Criança; 3. O Papel do professor na construção da Identidade da criança afrodescendente. A identidade da criança afrodescendente é construída nas séries iniciais da educação básica, ressaltando assim o papel fundamental em que a escola e os fatores que a compõem, como professores, livros didáticos, e quaisquer outros desempenham nesse processo. O professor deve se preparar para lidar com esses assuntos em sala de aula, e não apenas propagar estereótipos sobre a identidade da criança afrodescendente. Pensando nessa sociedade onde a intolerância, o desrespeito, preconceitos, racismos e discriminações têm estado tão presentes, as escolas e seus professores, são agentes com função mediadora pautam a capacidade de influenciar os cidadãos em processo de formação, assim devem lutar e buscar uma educação igualitária, que seja democrática e cidadã e valorize as identidades das crianças negras. Que essas crianças possam falar, mostrar e "vestir" sua identidade, sem medo e com orgulho.


Assuntos
Educação Infantil
20.
REVISA (Online) ; 7(3): 214-227, 2018.
Artigo em Português | LILACS | ID: biblio-1097145

RESUMO

Analisou-se a importância e a necessidade das formas de organização e gestão escolar. Foi realizado estudo qualitativo com análise do Projeto Político Pedagógico, observações de campo na escola pesquisada e entrevista com a diretora e professora. Para análise dos dados, foram localizadas categorias que possibilitaram compreender como os processos de organização e gestão da escola tem se materializado em seu contexto real e principalmente no que se refere aos processos de democratização das relações, funções e atividades da escola. Destacam-se as concepções e os princípios de gestão que foram produzidos ao longo História da educação brasileira, com ênfase no modelo de gestão democrático participativa. Consideram-se como problemática as dificuldades encontradas pelos gestores na consolidação de uma gestão verdadeiramente democrática no âmbito das escolas públicas estaduais


Assuntos
Ensino
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA