Detalhe da pesquisa
1.
Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations.
Bioorg Med Chem Lett
; 91: 129373, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37315697
2.
Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.
Amino Acids
; 47(3): 603-15, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25534430
3.
Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques.
Regul Toxicol Pharmacol
; 73(1): 27-42, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26111605
4.
1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity.
J Lipid Res
; 55(7): 1366-74, 2014 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755647
5.
Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.
Dig Dis Sci
; 59(2): 365-74, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24048683
6.
Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease.
Toxicol Appl Pharmacol
; 268(2): 132-40, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23391614
7.
NMR-based metabolomics of mammalian cell and tissue cultures.
J Biomol NMR
; 49(3-4): 195-206, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21373840
8.
Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling.
Anal Biochem
; 410(1): 84-91, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21094120
9.
Metabolomic and transcriptomic changes induced by overnight (16 h) fasting in male and female Sprague-Dawley rats.
Chem Res Toxicol
; 24(4): 481-7, 2011 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21381695
10.
Urinary metabolites of 2-bromoethanamine identified by stable isotope labelling: evidence for carbamoylation and glutathione conjugation.
Xenobiotica
; 41(2): 144-54, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21043805
11.
Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines.
Eng Life Sci
; 20(3-4): 112-125, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-32874175
12.
Metabolomic and quality data for early and late passages of an antibody-producing industrial CHO cell line.
Data Brief
; 33: 106591, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33318978
13.
Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling.
Magn Reson Chem
; 47 Suppl 1: S12-9, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19768707
14.
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
J Med Chem
; 62(20): 8953-8972, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31314518
15.
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
J Med Chem
; 62(20): 8973-8995, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31318208
16.
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
ACS Med Chem Lett
; 10(3): 383-388, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891145
17.
Nuclear magnetic resonance metabonomics: methods for drug discovery and development.
Methods Mol Biol
; 358: 247-71, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17035690
18.
Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model.
Obesity (Silver Spring)
; 25(6): 1069-1076, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28452429
19.
Understanding and Controlling Sialylation in a CHO Fc-Fusion Process.
PLoS One
; 11(6): e0157111, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27310468
20.
Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts.
Phytochemistry
; 62(6): 971-85, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12590124