RESUMO
Breast cancer continues to be one of the main causes of morbidity and mortality globally and was the leading cause of cancer death in women in Spain in 2020. Early diagnosis is one of the most effective methods to lower the incidence and mortality rates of breast cancer. The human metalloproteinases (MMP) mainly function as proteolytic enzymes degrading the extracellular matrix and plays important roles in most steps of breast tumorigenesis. This retrospective cohort study shows the immunohistochemical expression levels of MMP-1, MMP-2, MMP-3, and MMP-9 in 154 women with breast cancer and 42 women without tumor disease. The samples of breast tissue are assessed using several tissue matrices (TMA). The percentages of staining (≤50%->50%) and intensity levels of staining (weak, moderate, or intense) are considered. The immunohistochemical expression of the MMP-1-intensity (p = 0.043) and MMP-3 percentage (p = 0.018) and intensity, (p = 0.025) present statistically significant associations with the variable group (control-case); therefore, expression in the tumor tissue samples of these MMPs may be related to the development of breast cancer. The relationships between these MMPs and some clinicopathological factors in breast cancer are also evaluated but no correlation is found. These results suggest the use of MMP-1 and MMP-3 as potential biomarkers of breast cancer diagnosis.
Assuntos
Neoplasias da Mama/metabolismo , Metaloproteinase 1 da Matriz/metabolismo , Metaloproteinase 3 da Matriz/metabolismo , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/genética , Mama/patologia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/genética , Estudos de Casos e Controles , Estudos de Coortes , Progressão da Doença , Feminino , Humanos , Imuno-Histoquímica/métodos , Metaloproteinase 1 da Matriz/genética , Metaloproteinase 2 da Matriz/metabolismo , Metaloproteinase 3 da Matriz/genética , Metaloproteinase 9 da Matriz/metabolismo , Metaloproteases/genética , Metaloproteases/metabolismo , Pessoa de Meia-Idade , Estudos Retrospectivos , Espanha , Inibidores Teciduais de Metaloproteinases/metabolismoRESUMO
Los quistes broncogénicos son formaciones quísticas originadas por una anomalía de desarrollo del eje traqueobronquial durante la embriogénesis a partir de la pared ventral del intestino anterior. Se define al quiste broncogénico como una yema pulmonar ectópica cuya localización más frecuente es en la carina, intraparenquimatoso y en el mediastino; presenta otras localizaciones atípicas y menos comunes, como las regiones cervical, supraclavicular, esofágica, retroperitoneal y cutánea. Se presenta el caso de una mujer joven que consultó al servicio de urgencias con síntomas de dolor abdominal, a quien se le practicaron múltiples pruebas y se le diagnosticó un quiste broncogénico gástrico.
Bronchogenic cysts are cystic formations originated by a tracheobronchial axis developmental anomaly during embryogenesis from the ventral wall of the anterior intestine. A bronchogenic cyst is defined as an ectopic pulmonary bud with most frequent location in the carina, intraparenchymal and mediastinal, presenting atypical and less common locations such as the cervical, supraclavicular, esophageal, retroperitoneal, and cutaneous regions. We present the case of a young woman, who consults the emergency department with abdominal pain, who is subjected to multiple tests being diagnosed as gastric bronchogenic cyst