RESUMO
The pharmacokinetics (serum, urinary and biliary concentrations) of Isotiod have been studied in rats. Doses exploited the property of the molecule in an alkaline medium with a diazonium salt to form coloured azo compounds. In rats Isotiod determines blood concentrations whose intensity and duration are proportional to the dose and route of administration; notable quantities of the drug are eliminated by the urinary way and a small quantity by the bile way with a personal technique.
Assuntos
Propanolaminas/metabolismo , Animais , Bile/metabolismo , Cinética , Masculino , RatosRESUMO
A series of aliphatic and aromatic esters of 1,7,7-trimethyl-2-exo-piperidinobicyclo[2.2.1]heptan-3-endo-ol is described. A number of these compounds showed antiarrhythmic activity in guinea pigs and mice, as well as surface anesthesia in rabbits and infiltration anesthesia in mice. Circulatory, cardiac and respiratory effects in dogs are also described.
Assuntos
Anestésicos Locais/síntese química , Antiarrítmicos/síntese química , Canfanos/síntese química , Acetilcolina/antagonistas & inibidores , Animais , Pressão Sanguínea/efeitos dos fármacos , Canfanos/farmacologia , Fenômenos Químicos , Química , Frequência Cardíaca/efeitos dos fármacos , Antagonistas dos Receptores Histamínicos H1/síntese química , Camundongos , Coelhos , Respiração/efeitos dos fármacosRESUMO
Experimental investigations have shown that inosine enhances purinergic reactivity. This was examined with adenosine at the level of the cardiovascular, intestinal and uterine musculature. The mechanism of this activity may probably be inhibition of uptake without significantly altering serum adenosinase.