Switching From Originator to Biosimilar Infliximab in Paediatric Inflammatory Bowel Disease Is Feasible and Uneventful.

The safety, clinical efficacy, and cost-effectiveness of biosimilar infliximab in adult inflammatory bowel disease (IBD) have now been extensively shown. Limited data have been collected in the paediatric setting. We report nationwide, prospective, clinical safety and effectiveness data for patients from all 3 Scottish paediatric inflammatory bowel disease networks switching from originator to biosimilar infliximab. Prospective clinical data were collected for 33 patients. Information was collected from electronic patient records, laboratory reports, and patient case notes. There were no clinically significant changes to disease activity, biomarkers, antidrug antibodies, or trough drug levels (P > 0.1) within a 12-month follow-up period; in addition, there were no significant adverse events reported. No infusion reactions were seen in the 264 infusions delivered. Switching from originator infliximab to the biosimilar (CT-P13) appears to be associated with neither an increase in infusion reactions nor significant loss of effectiveness in the short term.

Breaking the Cycle: Understanding the Needs of Women Involved in the Criminal Justice System and the Role of Mentoring in Promoting Desistance.

An increasingly popular gender-specific intervention to assist women involved in the criminal justice system (e.g., ex-prisoners) is mentoring. However, despite the growing popularity of mentoring, there is a dearth of literature that has explored the intervention's efficacy, particularly as it relates to women involved in the criminal justice system. In the current study, client files of 64 women in a one-to-one mentoring program in Australia were examined to identify (a) the social and practical needs and obstacles faced by women overcoming their involvement with the justice system, and (b) the extent to which mentoring addressed these needs and obstacles. The results show that consistent with previous research, many of the women experienced a range of social and practical difficulties that impeded the desistance process. For a large portion of the women, however, mentoring helped overcome some difficulties by enhancing positive social capital in their lives. These findings are discussed in the context of how mentoring relationships can act as key turning points in the lives of women involved in the criminal justice system.