Detalhe da pesquisa
1.
A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.
J Inherit Metab Dis
; 39(6): 807-820, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27469509
2.
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
J Biol Chem
; 289(20): 13717-25, 2014 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24668804
3.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
Mol Cancer Ther
; 19(12): 2502-2515, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33082276
4.
Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.
ACS Med Chem Lett
; 11(2): 101-107, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071674
5.
Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant.
Biochemistry
; 48(49): 11622-9, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19899770
6.
Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase.
J Am Chem Soc
; 131(1): 200-11, 2009 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19128178
7.
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.
ACS Med Chem Lett
; 9(4): 300-305, 2018 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29670690
8.
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Cancer Discov
; 7(5): 478-493, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193778
9.
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.
Cell Rep
; 17(3): 876-890, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27732861
10.
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
Science
; 340(6132): 622-6, 2013 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23558173
11.
Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide.
J Am Chem Soc
; 127(21): 7729-38, 2005 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15913363