Evaluation of radiation dose for inferior vena cava filter placement during pregnancy: A comparison of dosimetry and dose calculation software.

Numerous medical conditions are associated with pregnancy in women, including pulmonary thromboembolism, which can be fatal. An effective treatment of this condition is the positioning of an inferior vena cava filter (IVC-F) under the guidance of X-ray imaging. However, this procedure involves the risk of high radiation exposure to pregnant women and fetuses. Moreover, there are no published reports comparing the values of fetal dose, received during IVC-F placement in pregnant women, determined using dose calculation software and actual measurements. To address this issue, we compared the fetal radiation dose and entrance surface dose (ESD) for pregnant women for gestation periods of 6 and 9 months based on software calculations and actual measurements. The ESD and fetal doses were estimated for a pregnant woman for gestation periods of 6 and 9 months during IVC-F placement. For actual measurements, one pregnant model phantom was constructed using an anthropomorphic phantom, and two custom-made different-sized abdomen phantoms were used to simulate pregnancy. The custom-made abdomen phantoms were constructed using polyurethane. For software calculations, the software utilized a set of anatomically realistic pregnant patient phantoms. The ESD estimated using the software was consistent with the measured ESD, but the fetal dose estimations were more complicated due to fetal positioning. During fetal dose evaluation using software calculations, the user must carefully consider how much of the fetal length is in the irradiation field to prevent underestimation or overestimation. Despite the errors, the software can assist the user in identifying the magnitude of the dose approaching critical limits.

Fetal radiation dose of four tube voltages in abdominal CT examinations during pregnancy: A phantom study.

This study aimed to compare the dose and noise level of four tube voltages in abdominal computerized tomography (CT) examinations in different abdominal circumference sizes of pregnant women. Fetal radiation doses were measured with two anthropomorphic pregnant phantoms and real-time dosimeters of photoluminescence sensors using four tube voltages for abdominal CT. The noise level was measured at the abdomen of two anthropomorphic pregnant phantoms. In the large pregnant phantom, the mean fetal doses performed using 120 and 135 kV were statistically significantly lower than the lower tube voltages (P < 0.05). In the small pregnant phantom, the mean fetal dose performed by 100, 120, and 135 kV was significantly lower than the lowest tube voltage tested (P < 0.05). The ratios of the peripheral mean dose to the centric mean dose showed that the ratios of 80 kV were the highest and those for 135 kV were the lowest in both pregnant phantoms. The ratios of the peripheral mean dose to the centric mean dose decreased as the tube voltage increased. Compared with low tube voltages, high tube voltages such as 120 and 135 kV could reduce radiation doses to the fetus without compromising the image uniformity in abdominal CT examinations during pregnancy. On low tube voltage protocols, the dose near the maternal skin surface may be increased in large pregnant women because of reduced penetration of the x rays.

Novel pregnant model phantoms for measurement of foetal radiation dose in x-ray examinations.

This study presents a comparison of novel pregnant model phantoms with a handmade phantom in terms of shape and radiation measurement points to determine which model is more suitable for measuring the foetal radiation dose during x-ray examinations. Novel pregnant model phantoms were constructed using an anthropomorphic phantom in combination with two differently-sized custom-made abdomen phantoms simulating pregnancy, which were constructed from a polyurethane resin. The size and shape of the polyurethane resin were designed based on abdominal sizes and shapes collected from the computed tomography examinations at 18 pregnant patients of one hospital. The handmade pregnant model phantom was constructed using an anthropomorphic phantom and a beach ball containing water. Compared with the handmade phantom, there were additional dose measurement points on the novel pregnant model phantoms. Our model phantoms improved upon the handmade phantom in terms of shape and radiation measurement points. We produced pregnant model phantoms that simulated the shapes and sizes of actual patients for the first time.

Proposed diagnostic reference levels for general radiography and mammography in Japan.

Diagnostic reference levels (DRLs 2015) in Japan were first published in 2017, on the Japan Network for Research and Information on Medical Exposures network. Medical facilities in Japan are now presumably reconsidering radiation doses at their facilities and approaching protection optimisation through the application of DRLs 2015. However, since more than 3 years have elapsed since publication, radiation doses received by patients in Japan may have diverged from DRLs 2015. We therefore undertook the present study. Based on our questionnaire survey implemented in 2017, we estimated the entrance skin dose (ESD) under general radiography fields and the mean glandular dose (MGD) under mammography, to compile a report on the doses received by patients under general radiography fields and mammography, and to propose new DRLs as replacements for DRLs 2015. Radiation doses under general radiography fields and mammography were estimated from the results of the 2017 questionnaire survey and applied to determine new DRLs at 75% values of dose distributions in general radiography fields and at 95% values of dose distributions in mammography. Among all the modes for general radiography fields and mammography, median ESD and MGD were significantly smaller with flat panel detector systems than with computed radiography systems. Comparison of the results with DRLs 2015 values showed a trend toward decreases in all imaging methods of the general radiography fields and mammography ranging from 5.0% (child chest radiography) to 31.7% (skull radiography). Moreover, responses showed that DRLs 2015 were recognised and used for comparison at many facilities. We have described the doses received by patients in general radiography fields and mammography in 2017 and proposed new DRLs as replacements for DRLs 2015. The DRLs we proposed for general radiography fields and mammography were determined to be lower than DRLs 2015 for all modes.

[Influence of Absorbed Dose by Difference of Scanning Starting Angle in Multiphasic CT Imaging].

Presently, the scanning start angle of the X-ray tube of X-ray computed tomography (CT) scanners cannot be controlled. As a result, there is room for reducing patient dose because the peaks of the dose distributions may overlap during multiphasic CT imaging. This study investigated methods of dose reduction by performing a Monte Carlo simulation of the X-ray tube scanning start angle and locally absorbed dose in multiphasic CT imaging. In the Monte Carlo simulation, the largest decrease in the absorbed dose was seen, when the scanning start angle between the phases was±180°. Even though with present X-ray CT scanners, the scanning start angle cannot be controlled, it is possible to decrease the absorbed dose by taking the orbital synchronized scanning and scanning range into consideration. In future we hope that, we will be able to easily reduce the dose by controlling the scanning start angle.

[Evaluation of Entrance Surface Dose in Chest Radiography Using Clinical Images: Estimation of Subject Thickness Using Two-direction Radiography].

The International Commission on Radiological Protection recommends adaptation of the diagnostic reference levels as an indicator of optimization of protection, and diagnostic reference levels of 2015 were also published in Japan in 2015 (Japan DRLs 2015). The entrance surface dose (ESD) is evaluated to the published standard subject thickness in Japan DRLs 2015. However, the standard radiographic settings of each facility may not be a radiographic condition of the standard subject thickness of Japan DRLs 2015. We measure and record the thickness of the subject in every examination, and it can solve this problem, but it is difficult to carry out it in the actual clinical scene. In this study, we aimed to estimate the subject thickness by using chest clinical images and to calculate ESD for each radiography. We evaluated and compared with Japan DRLs 2015 using these data. The subject thickness was estimated from 200 cases of digital imaging and communications in medicine (DICOM) image obtained by both the frontal and lateral views of the chest radiography. Also, at the same time, the radiographic settings were acquired from the information of the DICOM tag. The subject thickness was 23.60 cm on the average, and the median of the ESD was 0.104 mGy. Also, the median of the ESD at the standard subject thickness of 20 cm in Japan DRLs 2015 was 0.075 mGy. The ESD can be calculated without measuring the body thickness of the patient of every examination by using the method of this study.

Fetal dose conversion factor for fetal computed tomography examinations: A mathematical phantom study.

This study aimed to examine the relationship between fetal dose and the dose-length product, and to evaluate the impact of the number of rotations on the fetal doses and maternal effective doses using a 320-row multidetector computed tomography unit in a wide-volume mode. The radiation doses for the pregnant woman and the fetus were estimated using ImPACT CT Patient Dosimetry Calculator software for scan lengths ranging from 176 to 352 mm, using a 320-row unit in a wide-volume mode and an 80-row unit in a helical scanning mode. In the 320-row unit, the fetal doses in all scan lengths ranged from 3.51 to 6.52 mGy; the maternal effective doses in all scan lengths ranged from 1.05 to 2.35 mSv. In the 80-row unit, the fetal doses in all scan lengths ranged from 2.50 to 3.30 mGy; the maternal effective doses in all scan lengths ranged from 0.83 to 1.68 mSv. The estimated conversion factors from the dose-length product (mGy・cm) to fetal doses (mGy) for the 320-row unit in wide-volume mode and the 80-row unit in helical scanning mode were 0.06 and 0.05 (cm-1 ) respectively. While using a 320-row MDCT unit in a wide-volume mode, operators must take into account the number of rotations, the beam width as automatically determined by the scanner, the placement of overlap between volumetric sections, and the ratio of overlapping volumetric sections.

Evaluation of the Patient Exposure in General Radiography for Some Facilities: Comparison with DRL and Evaluation of the Difference among Facilities.

The first diagnostic reference levels (DRLs 2015) in Japan were published in June 2015. The purpose of this study was to compare the calculated entrance surface doses with the values of DRLs 2015, and evaluate differences in patient exposure among facilities. Semiconductor dosimeter was installed, and dosimetry was performed using equipment and radiographic condition of each facility. As a result, a dose higher than the value of DRLs 2015 was used in 12 kinds of examination. In child chest examination, the doses of the three facilities (0.26 mGy, 0.28 mGy, 0.60 mGy) exceeded the value of DRLs 2015 (0.2 mGy). Review of the radiographic condition is necessary because the doses exceeding DRLs 2015 tended to have a high current time product. The examination with the largest difference between facilities was the lateral of thoracic spine, with a difference of about 46 times, and the examination with the smallest difference was the ankle joint, with a difference of about three times. When reviewing, it is necessary to focus mainly on examinations that have a large difference between facilities. In the future, it can be said that it is necessary to set diagnostic reference range (DRR) or achievable dose (AD) to understand how high or low dose of the own facility are compared with facilities nationwide.

Electrocardiogram-gated coronary CT angiography dose estimates using ImPACT.

The primary study objective was to assess radiation doses using a modified form of the Imaging Performance Assessment of Computed Tomography (CT) scanner (ImPACT) patient dosimetry for cardiac applications on an Aquilion ONE ViSION Edition scanner, including the Ca score, target computed tomography angiography (CTA), prospective CTA, continuous CTA/cardiac function analysis (CFA), and CTA/CFA modulation. Accordingly, we clarified the CT dose index (CTDI) to determine the relationship between heart rate (HR) and X-ray exposure. As a secondary objective, we compared radiation doses using modified ImPACT, a whole-body dosimetry phantom study, and the k-factor method to verify the validity of the dose results obtained with modified ImPACT. The effective dose determined for the reference person (4.66 mSv at 60 beats per minute (bpm) and 33.43 mSv at 90bpm) were approximately 10% less than those determined for the phantom study (5.28 mSv and 36.68 mSv). The effective doses according to the k-factor (0.014 mSv•mGy-1•cm-1; 2.57 mSv and 17.10 mSv) were significantly lower than those obtained with the other two methods. In the present study, we have shown that ImPACT, when modified for cardiac applications, can assess both absorbed and effective doses. The results of our dose comparison indicate that modified ImPACT dose assessment is a promising and practical method for evaluating coronary CTA.

[Analysis of Scattered Radiation in an Irradiated Body by Means of the Monte Carlo Simulation: Back-scatter Factors of Diagnostic X-rays in the Incident Surface Which is Not Flat].

To obtain patient entrance surface dose in X-ray photography, a calculation method based on measured exposure or air kerma radiated from X-ray tube is generally used. Two factors are necessary for this calculation: (1) exposure/air kerma to absorb dose conversion factor and (2) back-scatter factor (BSF) based on X-ray quality and on field size. These BSFs are commonly obtained by interpolation from existent data which were given for a water phantom whose entrance surface is flat. Since patient's surface in X-ray photograph is not flat, some error may occur when existent BSF is used in this calculation. In this article, BSF for water phantom with cylindrical surface and elliptic cylinder surface were calculated by means of the Monte Carlo simulation. And these BSFs were compared with BSF for flat surface phantom. As a result (1) radius of curvature of cylindrical phantom or horizontal axis of elliptic cylinder phantom is smaller, (2) half value layer of X-ray is larger, (3) field size is larger, difference of these BSF with that for flat surface phantom tends to be larger. Maximum difference by calculation condition assumed in this article was more than 10%. The cause of this difference is because scattering volume in irradiated body of cylindrical or elliptic cylinder phantom is smaller than flat surface phantom. To obtain patient entrance surface dose more precisely, it is necessary to use BSF respectively calculated for phantom resembling patient's body such as cylindrical or elliptic cylinder phantom by means of the Monte Carlo simulation.

[Estimation of the Average Glandular Dose Using the Mammary Gland Image Analysis in Mammography].

Currently, the glandular dose is evaluated quantitatively on the basis of the measured data using phantom, and not in a dose based on the mammary gland structure of an individual patient. However, mammary gland structures of the patients are different from each other and mammary gland dose of an individual patient cannot be obtained by the existing methods. In this study, we present an automated estimation method of mammary gland dose by means of mammary structure which is measured automatically using mammogram. In this method, mammary gland structure is extracted by Gabor filter; mammary region is segmented by the automated thresholding. For the evaluation, mammograms of 100 patients diagnosed with category 1 were collected. Using these mammograms we compared the mammary gland ratio measured by proposed method and visual evaluation. As a result, 78% of the total cases were matched. Furthermore, the mammary gland ratio and average glandular dose among the patients with same breast thickness was matched well. These results show that the proposed method may be useful for the estimation of average glandular dose for the individual patients.

Evaluation of organ doses and effective dose according to the ICRP Publication 110 reference male/female phantom and the modified ImPACT CT patient dosimetry.

We modified the Imaging Performance Assessment of CT scanners (ImPACT) to evaluate the organ doses and the effective dose based on the International Commission on Radiological Protection (ICRP) Publication 110 reference male/female phantom with the Aquilion ONE ViSION Edition scanner. To select the new CT scanner, the measurement results of the CTDI100,c and CTDI100,p for the 160 (head) and the 320 (body) mm polymethylmethacrylate phantoms, respectively, were entered on the Excel worksheet. To compute the organ doses and effective dose of the ICRP reference male/female phantom, the conversion factors obtained by comparison between the organ doses of different types of phantom were applied. The organ doses and the effective dose were almost identical for the ICRP reference male/female and modified ImPACT. The results of this study showed that, with the dose assessment of the ImPACT, the difference in sex influences only testes and ovaries. Because the MIRD-5 phantom represents a partially hermaphrodite adult, the phantom has the dimensions of the male reference man including testes, ovaries, and uterus but no female breasts, whereas the ICRP male/female phantom includes whole-body male and female anatomies based on high-resolution anatomical datasets. The conversion factors can be used to estimate the doses of a male and a female accurately, and efficient dose assessment can be performed with the modified ImPACT.

Assessment of fetal radiation exposure in pregnant women undergoing computed tomography and rotational angiography examinations for pelvic trauma.

This study aimed to assess fetal radiation exposure in pregnant women undergoing computed tomography (CT) and rotational angiography (RA) examinations for the diagnosis of pelvic trauma. In addition, this study aimed to compare the dose distributions between the two examinations. Surface and average fetal doses were estimated during CT and RA examinations using a pregnant phantom model and real-time dosemeters. The pregnant model phantom was constructed using an anthropomorphic phantom, and a custom-made abdominal phantom was used to simulate pregnancy. The total average fetal dose received by pregnant women from both CT scans (plain, arterial and equilibrium phases) and a single RA examination was ~60 mGy. Because unnecessary repetition of radiographic examinations, such as CT or conventional 2D angiography can increase the radiation risk, the irradiation range should be limited, if necessary, to reduce overall radiation exposure.

Estimating organ dose with optimized peak dose index in cone-beam CT scans.

PURPOSE: Organ dose evaluation is important for optimizing cone beam computed tomography (CBCT) scan protocols. However, an evaluation method for various CBCT scanners is yet to be established. In this study, we developed scanner-independent conversion coefficients to estimate organ doses using appropriate peak dose (f(0)) indices. METHODS: This study included various scanners (angiography scanners and linear accelerators) and protocols for the head and body (thorax, abdomen, and pelvis) scan regions. f(0) was measured at five conventional positions (center position (f(0)c) and four peripheral positions (f(0)p) at 90° intervals) in the CT dose index (CTDI) phantom. To identify appropriate measurement positions for organ dose estimation, various f(0) indices were considered. Organ doses were measured by using optically stimulated luminescence dosimeters positioned in an anthropomorphic phantom. Thereafter, the conversion coefficients were calculated from each obtained f(0) value and organ or tissue dose using a linear fit for all scanners, and the coefficient of variation (CV) of the conversion coefficients was calculated for each organ or tissue. The f(0) index with the minimum CV value was proposed as the appropriate index. RESULTS: The appropriate f(0) index was determined as f(0)c for the body region and a maximum of four f(0)p values for the head region. Using the proposed conversion coefficients based on the appropriate f(0) index, the organ/tissue doses were well estimated with a mean error of 14.2% across all scanners and scan regions. CONCLUSIONS: The proposed scanner-independent coefficients are useful for organ dose evaluation using CBCT scanners.

[Investigation of patient exposure doses in diagnostic radiography in 2011 questionnaire].

We report here the results of a dose evaluation based on information obtained in a 2011 questionnaire as compared with an investigation made in 2007. Briefly, in general radiography, the dose used in most examinations in 2011 was lower than in 2007. However, since the entrance surface dose for chest X-rays showed an increase, there is a need to standardize the taking of digital images to be able to decrease the dose. Although computed tomography dose index volume (CTDIvol) in CT examinations was higher than that revealed in the 2007 investigation, there is potential for dose reduction.

[Dose estimation for exposure conditions of diagnostic radiology acquired by a 2011 questionnaire in a phantom study].

Using a 2011 questionnaire, the Japanese Society of Radiological Technology conducted a nationwide survey on the exposure conditions in diagnostic radiography. The purpose of this study was to measure the entrance surface dose and absorbed dose for each organ dose and to calculate the effective dose using a human phantom with the 2011 exposure conditions. We estimated the patient exposure doses during skull (antero-posterior), chest (postero-anterior), abdomen (antero-posterior), and lumbar vertebrae (antero-posterior, left-right, and right-left) radiographs. The radiation doses were determined by placing 255 thermoluminescence dosimeters at various positions on and in the phantom, including the surface of the skin, head, thyroid, lung, breast, esophagus, stomach, liver, and gonads. The maximum entrance surface dose was 7.83 mGy, which occurred to the lateral lumbar spine. In addition, the minimum entrance surface dose was 0.24 mGy, to the chest. The maximum organ dose was 3.15 mGy, to the stomach of the lateral lumbar vertebrae (LR). Meanwhile, the maximum effective dose was 0.63 mSv, to the lateral lumbar vertebrae (LR). On the contrary, the minimum effective dose was 0.03 mSv, to the head. We could evaluate the entrance surface dose, absorbed dose for each organ dose, and effective doses using the 2011 exposure conditions in Japan. The entrance surface dose of 5 examinations with these exposure conditions was below the guidance level of the IAEA. In the future, it can be said that the entrance surface dose as well as the effective dose require diagnostic reference levels in radiography.

Optimal conversion coefficient from easily measurable dose to effective dose with consideration to radiation quality for posterior-anterior chest radiography.

Effective dose is sometimes used to compare medical radiation exposure to patients and natural radiation for providing explanations about radiation exposure to patients, but its calculation is lengthy and requires dedicated measuring devices. The purpose of this study was to identify the most suitable conversion coefficient for conversion of easily measurable dose to effective dose in posterior-anterior chest radiography, and to evaluate its accuracy by direct measurement. We constructed an examination environment using Monte Carlo simulation, and evaluated the variation in conversion coefficients from incident air kerma (IAK), entrance-surface air kerma (ESAK), and air kerma-area product (KAP) to effective dose when the irradiation field size and radiation quality were changed. Effective doses were also measured directly using thermoluminescence dosimeters and compared with the effective dose obtained from conversion coefficients. The KAP conversion coefficient most effectively suppressed the effect of irradiation field size, and was then used to set conversion coefficients for various half-value layers. The optimal conversion coefficient was 0.00023 [mSv/(mGy·cm2)] at 120 kVp (half-value layer = 5.5 mmAl). Evaluation of the direct measurements obtained with various radiation qualities revealed that the accuracy of the conversion coefficient was maintained at ≤ 11%. The proposed conversion coefficient can be easily calculated even in facilities that do not have equipment for measuring effective dose, and might enable the use of effective dose for providing explanations about radiation exposure to patients.

Physical and visual evaluations of CT image quality of large low-contrast objects with visual model-based iterative reconstruction technique: a phantom study.

We aimed to verify whether the image quality of large low-contrast objects can be improved using visual model-based iterative reconstruction (VMR) while maintaining the visibility of conventional filtered back projection (FBP) and reducing radiation dose through physical and visual evaluation. A 64-row multi-slice CT system with SCENARIA View (FUJIFILM healthcare Corp. Tokyo, Japan) was used. The noise power spectrum (NPS), task-based transfer function (TTF), and signal-to-noise ratio (SNR) were physically evaluated. A low contrast object as a substitute for a liver mass was visually evaluated. In the noise measurement, STD1 showed an 18% lower noise compared to FBP. STR4 was able to reduce noise by 58% compared to FBP. The NPS of VMR was similar to those of FBP from low to high spatial frequency. The NPS of VMR reconstructions showed a similar variation with frequency as FBP reconstructions. STD1 showed the highest 10% TTF, and higher 10% TTF was observed with lower VMR level. The SNR of VMR was close to that of FBP, and higher SNR was observed with higher VMR level. In the results of the visual evaluation, there was no significant difference in visual evaluation between STD1 and FBP (p = 0.99) and between STD2 and FBP (p = 0.56). We found that the NPS of VMR images was similar to that of FBP images, and it can reduce noise and radiation dose by 25% and 50%, respectively, without decreasing the visual image quality compared to FBP.

[Summary of results of the patient exposures in diagnostic radiography in 2011 questionnaire-focus on radiographic conditions-].

We carried out a questionnaire survey to research on radiographic conditions in 3000 institutes. We discussed on radiographic conditions to estimate patient exposures. The collection rate was 24.7%. Most of the institutes shifted to the use of high-voltage generator, digital devices, and filmless equipment. We did not see a shift in this survey of radiographic conditions compared with the 2007 survey.

SIZE-SPECIFIC DOSE ESTIMATES IN FETAL COMPUTED TOMOGRAPHY.

During fetal computed tomography (CT) imaging, because of differences in the pregnancy period and scanning conditions, different doses of radiation are absorbed by the fetus. We propose a correction coefficient for determining the fetal size-specific dose estimate (SSDE) from the CT dose index (CTDI) displayed on the console at tube voltages of 80-135 kVp. The CTDIs corresponding to pregnant women and fetuses were evaluated using a Monte Carlo (MC) simulation, and the ratio of these CTDIs was defined as the Fetus-factor. When the effective diameter of a fetus was approximately 10 cm, the Fetus-factor was 1.0. The estimated pregnant SSDE was multiplied by the Fetus-factor to estimate the fetal SSDE, which was compared with the fetal dose obtained by the MC simulation of the image of the fetal CT examination. The fetal dose could be estimated with an error of 31.5% in fetal examinations conducted using helical CT.