Histopathological graded liver lesions: what role does the IVIM analysis method have?

PURPOSE: This study aims to investigate three different image processing methods on quantitative parameters of IVIM sequence, as well as apparent diffusion coefficients and simple perfusion fractions, for benign and malignant liver tumors. MATERIALS AND METHODS: IVIM images with 8 b-values (0-1000 s/mm2) and 1.5 T MRI scanner in 16 patients and 3 healthy people were obtained. Next, the regions of interest were selected for malignant, benign, and healthy liver regions (50, 56, and 12, respectively). Then, the bi-exponential equation of the IVIM technique was fitted with two segmented fitting methods as well as one full fitting method (three methods in total). Using the segmented fitting method, diffusion coefficient (D) is fixed with a mono-exponential equation with b-values that are greater than 200 s/mm2. The perfusion fraction (f) can then be calculated by extrapolating, as the first method, or fitting simultaneously with the pseudo-diffusion coefficient (D*) as the second method. In the full fitting method, as the third method, all IVIM parameters were obtained simultaneously. The mean values of parameters from different methods were compared in different grades of lesions. RESULTS: Our results indicate that the image processing method can change statistical comparisons between different groups for each parameter. The D value is the only quantity in this technique that does not depend on the fitting process and can be used as an indicator of comparison between studies (P < 0.05). The most effective method to distinguish liver lesions is the extrapolated f method (first method). This method created a significant difference (P < 0.05) between the perfusion parameters between benign and malignant lesions. CONCLUSION: Using extrapolated f is the most effective method of distinguishing liver lesions using IVIM parameters. The comparison between groups does not depend on the fitting method only for parameter D.

EYE LENS DOSE OPTIMIZATION THROUGH GANTRY TILTING IN BRAIN CT SCAN: THE POTENTIAL EFFECT OF THE RADIOLOGICAL TECHNOLOGISTS' TRAINING.

This study was designed to evaluate the effect of the radiological technologists' training on optimising the eye lens dose in brain computed tomography (CT) examinations. The lens dose of 50 adult patients was measured using thermoluminescent dosimeters before and after technologists' training. Dose values of lenses, dose length product (DLP), volumetric CT dose index (CTDIvol) as well as image quality in terms of quantitative (contrast to noise ratio and signal to noise ratio) and subjective (artefact) parameters were compared before and after training. Lens dose values were 31.57 ± 9.84 mGy and 5.36 ± 1.53 mGy before and after training, respectively, which was reduced by ~83% (p < 0.05). The values of DLP, CTDIvol and image quality parameters were not significantly different (p > 0.05) and all images were diagnostically acceptable. Excluding the orbits from the scanning range is an efficient approach to optimize the lens dose; the training of the technologists has also a pivotal role in dose reducing.

Doses to patients in some routine diagnostic X-ray examinations in Iran: proposed the first Iranian diagnostic reference levels.

The national diagnostic reference levels (NDRLs) form an efficient, concise and powerful standard for optimising the radiation protection of a patient. With an aim to establish the first Iranian NDRLs, the nationwide survey of the frequency of medical X-ray examinations and entrance surface doses received by the patients during the most typical X-ray examinations has been performed. Seven most common X-ray examinations in 14 projections were included in the list of procedures under consideration. Hospitals of different sizes and levels using different X-ray machines were represented in the survey. The standard thermoluminescence dosimeters were applied to measure entrance surface dose (ESD). A total of 1601 patients were included in this study. The data were analysed statistically, and the minimum, median, mean, maximum, first and third quartile values of ESDs are reported. Finally, the proposed Iranian DRLs are compared with the international reference dose values reported by the European Commission, the International Atomic Energy Agency and the National Radiological Protection Board.

Local diagnostic reference levels for some common diagnostic X-ray examinations in Tehran county of Iran.

Various researchers who have carried out national and international surveys have reported wide variations in patient dose arising from specific X-ray examinations. This study was carried out as a part of a comprehensive project to establish national diagnostic reference level (NDRL), for the first time, in Iran. Seven most common X-ray examinations in 11 projections were included. Thermo luminescence dosimeters (TLD-100) were used to measure entrance surface doses (ESDs). The study group consisted of 535 patients who were referred for X-ray examinations to 12 randomly selected public hospitals in Tehran County. Minimum, median, mean, maximum, first and third quartile values of ESDs are reported. Our results are evident that mean dose values of patients undertaking a specific examination are widely different in various hospitals. Wide dose differences may emerge from complex causes, but in general, low peak kilovoltage and high milli Amperes are associated with higher doses. The results of this work together with further data expected to emerge from the work in progress will provide a useful base to establish Iran's DRLs.

An Evaluation of the Organ Dose Received by Cardiologists Arising From Angiography Examinations in Educational Hospital in Rasht.

Interventional procedures, cine acquisitions and operation of fluoroscopic equipment in high-dose fluoroscopic modes, involve long fluoroscopic times which can lead to high staff doses. Also, Coronary angiography (CA) procedures require the cardiologist and assisting personnel to remain close to the patient, which is the main source of scattered radiation. Thus, radiation exposure is a significant concern for radiation workers and it is important to measure the radiation doses received by personnel and evaluate the parameters concerning total radiation burden. In this research, we investigated radiation doses to 10 cardiologists performing 120 CA procedures. Using thermo luminescent dosimeters doses to the wrists, thyroid and eyes per procedure were measured. Based on the measured dose values, maximum doses to the Left wrist, Right wrist, thyroid and eyes of cardiologist were measured 241.45 µSv, 203.17 µSv, 78.21 µSv and 44.58 µSv, respectively. The results of this study indicate that distance from the source, use of protective equipment's, procedure complexity, equipment performance, and cardiologist experience are the principal exposure-determining variables. It can be conclude that if adequate radiation protection approaches have been implemented, occupational dose levels to cardiologists would be within the regulated acceptable dose limits.

The Endemicity of Human Fascioliasis in Guilan Province, Northern Iran: the Baseline for Implementation of Control Strategies.

BACKGROUND: The largest global outbreaks of liver fluke disease (Fascioliasis) in humans, caused by species of the genus Fasciola, have occurred in Guilan Province of Iran, affecting more than 15000 people. Although, different aspects of fascioliasis have been the subject of various researches during last two decades, nevertheless no community-based study has been performed in endemic regions of Guilan. The aim of present study was to obtain the basic information needed to develop future control strategies. METHODS: Fecal and blood samples were collected from 1,984 volunteers in the Bandar-Anzali district, the region where previous epidemics occurred. Fecal samples were examined by Kato-Katz and formalin-ether methods for the presence of Fasciola eggs. Sera samples were analyzed by ELISA to detect anti-cathepsin L antibodies. RESULTS: Twenty-seven (1.36%) individuals were seropositive, 9 (0.45%) individuals were egg positive (mean egg count 50.7 (±30.36) eggs per gram of faeces) and 30 individuals (1.51%) were positive using both methods. No statistical association was observed between infection and age, gender, location, occupation, educational status and dietary habits. The prevalence of intestinal parasites is also included. CONCLUSION: Human fascioliasis is hypoendemic in this region and recommends a passive case-finding approach, effective primary prevention measures, health education through mass media and effective veterinary public health measures for control of human disease.