Detalhe da pesquisa
1.
Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
Mol Cell
; 72(1): 178-186.e5, 2018 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30270109
2.
Utilization of diverse organophosphorus pollutants by marine bacteria.
Proc Natl Acad Sci U S A
; 119(32): e2203604119, 2022 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35917352
3.
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.
Mol Cell
; 63(2): 337-346, 2016 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27425410
4.
Quinone Methide-Based Organophosphate Hydrolases Inhibitors: Trans Proximity Labelers versus Cis Labeling Activity-Based Probes.
Chembiochem
; 22(5): 894-903, 2021 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105515
5.
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.
Mol Cell
; 70(2): 380, 2018 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29677494
6.
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.
Arch Toxicol
; 90(11): 2711-2724, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26612364
7.
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nat Chem Biol
; 8(3): 294-300, 2012 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22306579
8.
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro.
Arch Toxicol
; 88(6): 1257-66, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24477626
9.
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.
Nat Chem Biol
; 7(2): 120-5, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21217689
10.
The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.
Acta Crystallogr D Struct Biol
; 79(Pt 11): 992-1009, 2023 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37860961
11.
Design of a stable human acid-ß-glucosidase: towards improved Gaucher disease therapy and mutation classification.
FEBS J
; 290(13): 3383-3399, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808692
12.
Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Protein Sci
; 30(5): 966-981, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33686648
13.
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors.
Biochemistry
; 48(3): 563-74, 2009 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19115961
14.
A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents.
Protein Eng Des Sel
; 32(4): 169-174, 2019 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31612205
15.
Catalytic bioscavengers as countermeasures against organophosphate nerve agents.
Chem Biol Interact
; 292: 50-64, 2018 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29990481
16.
Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.
Protein Eng Des Sel
; 30(4): 333-345, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28159998
17.
In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.
Chem Biol Interact
; 259(Pt B): 252-256, 2016 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27163850
18.
A new post-intoxication treatment of paraoxon and parathion poisonings using an evolved PON1 variant and recombinant GOT1.
Chem Biol Interact
; 259(Pt B): 242-251, 2016 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27256520
19.
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection.
Toxicol Lett
; 258: 198-206, 2016 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27397758
20.
The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Sci
; 25(6): 1096-114, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26990888