A whole-task brain model of associative recognition that accounts for human behavior and neuroimaging data.

Brain models typically focus either on low-level biological detail or on qualitative behavioral effects. In contrast, we present a biologically-plausible spiking-neuron model of associative learning and recognition that accounts for both human behavior and low-level brain activity across the whole task. Based on cognitive theories and insights from machine-learning analyses of M/EEG data, the model proceeds through five processing stages: stimulus encoding, familiarity judgement, associative retrieval, decision making, and motor response. The results matched human response times and source-localized MEG data in occipital, temporal, prefrontal, and precentral brain regions; as well as a classic fMRI effect in prefrontal cortex. This required two main conceptual advances: a basal-ganglia-thalamus action-selection system that relies on brief thalamic pulses to change the functional connectivity of the cortex, and a new unsupervised learning rule that causes very strong pattern separation in the hippocampus. The resulting model shows how low-level brain activity can result in goal-directed cognitive behavior in humans.

Improving With Practice: A Neural Model of Mathematical Development.

The ability to improve in speed and accuracy as a result of repeating some task is an important hallmark of intelligent biological systems. Although gradual behavioral improvements from practice have been modeled in spiking neural networks, few such models have attempted to explain cognitive development of a task as complex as addition. In this work, we model the progression from a counting-based strategy for addition to a recall-based strategy. The model consists of two networks working in parallel: a slower basal ganglia loop and a faster cortical network. The slow network methodically computes the count from one digit given another, corresponding to the addition of two digits, whereas the fast network gradually "memorizes" the output from the slow network. The faster network eventually learns how to add the same digits that initially drove the behavior of the slower network. Performance of this model is demonstrated by simulating a fully spiking neural network that includes basal ganglia, thalamus, and various cortical areas. Consequently, the model incorporates various neuroanatomical data, in terms of brain areas used for calculation and makes psychologically testable predictions related to frequency of rehearsal. Furthermore, the model replicates developmental progression through addition strategies in terms of reaction times and accuracy, and naturally explains observed symptoms of dyscalculia.