Detalhe da pesquisa
1.
Plitidepsin as an Immunomodulator against Respiratory Viral Infections.
J Immunol
; 212(8): 1307-1318, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38416036
2.
Plocabulin, a Novel Tubulin Inhibitor, Has Potent Antitumour Activity in Patient-Derived Xenograft Models of Soft Tissue Sarcoma.
Int J Mol Sci
; 23(13)2022 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35806460
3.
Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells.
BMC Cancer
; 18(1): 164, 2018 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29415678
4.
Improved pharmacokinetic profile of lipophilic anti-cancer drugs using ανß3-targeted polyurethane-polyurea nanoparticles.
Nanomedicine
; 14(2): 257-267, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29127040
5.
Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone.
Haematologica
; 102(1): 168-175, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27540138
6.
Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis.
BMC Cancer
; 14: 281, 2014 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24758355
7.
Nano-encapsulation of plitidepsin: in vivo pharmacokinetics, biodistribution, and efficacy in a renal xenograft tumor model.
Pharm Res
; 31(4): 983-91, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24287622
8.
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin.
J Med Chem
; 67(4): 2619-2630, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38294341
9.
c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity.
Mar Drugs
; 11(5): 1677-92, 2013 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23697951
10.
Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS.
PLoS One
; 18(3): e0283783, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36996147
11.
Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of KV1.3 and KV1.5 channels.
Biomed Pharmacother
; 161: 114548, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36940615
12.
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis.
Antiviral Res
; 200: 105270, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35231500
13.
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.
Life Sci Alliance
; 5(4)2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35012962
14.
Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.
Blood
; 113(16): 3781-91, 2009 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19020308
15.
Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.
Haematologica
; 96(5): 687-95, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21330323
16.
Evaluation of the Preclinical Efficacy of Lurbinectedin in Malignant Pleural Mesothelioma.
Cancers (Basel)
; 13(10)2021 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34066159
17.
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
Science
; 371(6532): 926-931, 2021 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33495306
18.
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.
bioRxiv
; 2021 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33501437
19.
Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.
medRxiv
; 2021 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34075384
20.
Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors.
Transl Oncol
; 13(11): 100832, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32711367