Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Intervalo de ano de publicação
1.
Science ; 345(6198): 818-22, 2014 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-25124441

RESUMO

Lung disease in people with cystic fibrosis (CF) is initiated by defective host defense that predisposes airways to bacterial infection. Advanced CF is characterized by a deficit in mucociliary transport (MCT), a process that traps and propels bacteria out of the lungs, but whether this deficit occurs first or is secondary to airway remodeling has been unclear. To assess MCT, we tracked movement of radiodense microdisks in airways of newborn piglets with CF. Cholinergic stimulation, which elicits mucus secretion, substantially reduced microdisk movement. Impaired MCT was not due to periciliary liquid depletion; rather, CF submucosal glands secreted mucus strands that remained tethered to gland ducts. Inhibiting anion secretion in non-CF airways replicated CF abnormalities. Thus, impaired MCT is a primary defect in CF, suggesting that submucosal glands and tethered mucus may be targets for early CF treatment.


Assuntos
Fibrose Cística/fisiopatologia , Glândulas Exócrinas/metabolismo , Depuração Mucociliar , Muco/metabolismo , Mucosa Respiratória/fisiopatologia , Sistema Respiratório/fisiopatologia , Animais , Animais Recém-Nascidos , Ânions/metabolismo , Cílios/fisiologia , Regulador de Condutância Transmembrana em Fibrose Cística/fisiologia , Modelos Animais de Doenças , Pulmão/fisiopatologia , Cloreto de Metacolina/farmacologia , Suínos , Traqueia/fisiopatologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA