Pesquisa | Portal de Pesquisa da BVS

1.

Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.

Macdonald, Lynn E; Meagher, Karoline A; Franklin, Matthew C; Levenkova, Natasha; Hansen, Johanna; Badithe, Ashok T; Zhong, Maggie; Krueger, Pamela; Rafique, Ashique; Tu, Naxin; Shevchuk, James; Wadhwa, Saurabh; Ehrlich, George; Bautista, Joannie; Grant, Craig; Esau, Lakeisha; Poueymirou, William T; Auerbach, Wojtek; Morton, Lori; Babb, Robert; Chen, Gang; Huang, Tammy; MacDonald, Douglas; Graham, Kenneth; Gurer, Cagan; Voronina, Vera A; McWhirter, John R; Guo, Chunguang; Yancopoulos, George D; Murphy, Andrew J.

Proc Natl Acad Sci U S A ; 117(1): 292-299, 2020 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-31879340

2.

Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates.

Pascal, Kristen E; Dudgeon, Drew; Trefry, John C; Anantpadma, Manu; Sakurai, Yasuteru; Murin, Charles D; Turner, Hannah L; Fairhurst, Jeanette; Torres, Marcela; Rafique, Ashique; Yan, Ying; Badithe, Ashok; Yu, Kevin; Potocky, Terra; Bixler, Sandra L; Chance, Taylor B; Pratt, William D; Rossi, Franco D; Shamblin, Joshua D; Wollen, Suzanne E; Zelko, Justine M; Carrion, Ricardo; Worwa, Gabriella; Staples, Hilary M; Burakov, Darya; Babb, Robert; Chen, Gang; Martin, Joel; Huang, Tammy T; Erlandson, Karl; Willis, Melissa S; Armstrong, Kimberly; Dreier, Thomas M; Ward, Andrew B; Davey, Robert A; Pitt, Margaret L M; Lipsich, Leah; Mason, Peter; Olson, William; Stahl, Neil; Kyratsous, Christos A.

J Infect Dis ; 218(suppl_5): S612-S626, 2018 11 22.

Artigo em Inglês | MEDLINE | ID: mdl-29860496

3.

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection.

Pascal, Kristen E; Coleman, Christopher M; Mujica, Alejandro O; Kamat, Vishal; Badithe, Ashok; Fairhurst, Jeanette; Hunt, Charleen; Strein, John; Berrebi, Alexander; Sisk, Jeanne M; Matthews, Krystal L; Babb, Robert; Chen, Gang; Lai, Ka-Man V; Huang, Tammy T; Olson, William; Yancopoulos, George D; Stahl, Neil; Frieman, Matthew B; Kyratsous, Christos A.

Proc Natl Acad Sci U S A ; 112(28): 8738-43, 2015 Jul 14.

Artigo em Inglês | MEDLINE | ID: mdl-26124093

4.

Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain.

Somersan-Karakaya, Selin; Turner, Kenneth C; Cortes-Burgos, Luz; Miller, Jutta; LaCroix-Fralish, Michael; Logovinsky, Veronika; Patel, Yamini; Torres, Richard; Ganguly, Samit; Breazna, Aurora; DeVeaux, Michelle; Bhore, Rafia; Gao, Min; Delfino, Frank J; Rafique, Ashique; Fairhurst, Jeanette L; Hunt, Charleen; Babb, Robert; Badithe, Ashok; Poueymirou, William T; Surowitz, Ronald; Rottey, Sylvie; Murphy, Andrew J; Harari, Olivier; Macdonald, Lynn E; Croll, Susan D.

Neurobiol Pain ; 14: 100136, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-38099276

5.

Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning.

Haber, Lauric; Olson, Kara; Kelly, Marcus P; Crawford, Alison; DiLillo, David J; Tavaré, Richard; Ullman, Erica; Mao, Shu; Canova, Lauren; Sineshchekova, Olga; Finney, Jennifer; Pawashe, Arpita; Patel, Supriya; McKay, Ryan; Rizvi, Sahar; Damko, Ermelinda; Chiu, Danica; Vazzana, Kristin; Ram, Priyanka; Mohrs, Katja; D'Orvilliers, Amanda; Xiao, Jenny; Makonnen, Sosina; Hickey, Carlos; Arnold, Cody; Giurleo, Jason; Chen, Ya Ping; Thwaites, Courtney; Dudgeon, Drew; Bray, Kevin; Rafique, Ashique; Huang, Tammy; Delfino, Frank; Hermann, Aynur; Kirshner, Jessica R; Retter, Marc W; Babb, Robert; MacDonald, Douglas; Chen, Gang; Olson, William C; Thurston, Gavin; Davis, Samuel; Lin, John C; Smith, Eric.

Sci Rep ; 11(1): 14397, 2021 07 13.

Artigo em Inglês | MEDLINE | ID: mdl-34257348

6.

Humanization of T cell-mediated immunity in mice.

Moore, Michael J; Zhong, Maggie; Hansen, Johanna; Gartner, Hans; Grant, Craig; Huang, Mei; Harris, Faith M; Tu, Naxin; Bowerman, Natalie A; Edelmann, Kurt H; Barry, Thomas; Herbin, Olivier; Tay, Chin-Siean; DiLillo, David J; Decker, Corinne E; Levenkova, Natasha; Shevchuk, James; Dhanik, Ankur; Meagher, Karoline A; Karr, Amanda; Roos, Jan; Lee, Wen-Yi; Suh, David; Eckersdorff, Mark; Meagher, T Craig; Koss, Matthew; Esau, Lakeisha; Sleeman, Matthew A; Babb, Robert; Chen, Gang; Kyratsous, Christos A; Poueymirou, William T; McWhirter, John R; Voronina, Vera A; Guo, Chunguang; Gurer, Cagan; Yancopoulos, George D; Murphy, Andrew J; Macdonald, Lynn E.

Sci Immunol ; 6(66): eabj4026, 2021 Dec 17.

Artigo em Inglês | MEDLINE | ID: mdl-34919442

7.

A Biparatopic Antibody That Modulates MET Trafficking Exhibits Enhanced Efficacy Compared with Parental Antibodies in MET-Driven Tumor Models.

DaSilva, John O; Yang, Katie; Perez Bay, Andres E; Andreev, Julian; Ngoi, Peter; Pyles, Erica; Franklin, Matthew C; Dudgeon, Drew; Rafique, Ashique; Dore, Anthony; Delfino, Frank J; Potocky, Terra B; Babb, Robert; Chen, Gang; MacDonald, Douglas; Olson, William C; Thurston, Gavin; Daly, Christopher.

Clin Cancer Res ; 26(6): 1408-1419, 2020 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-31848185

8.

Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5.

Latuszek, Adrianna; Liu, Yashu; Olsen, Olav; Foster, Randi; Cao, Marc; Lovric, Irena; Yuan, Ming; Liu, Nina; Chen, Henry; Zhang, Qian; Xiao, Hui; Springer, Carola; Ehrlich, George; Kamat, Vishal; Rafique, Ashique; Hu, Ying; Krueger, Pamela; Huang, Tammy; Poueymirou, William; Babb, Robert; Rosconi, Michael P; Retter, Marc W; Chen, Gang; Morton, Lori; Zambrowicz, Brian; Cao, Jingtai; Romano, Carmelo; Olson, William C.

PLoS One ; 15(5): e0231892, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-32384086

9.

Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy.

Waite, Janelle C; Wang, Bei; Haber, Lauric; Hermann, Aynur; Ullman, Erica; Ye, Xuan; Dudgeon, Drew; Slim, Rabih; Ajithdoss, Dharani K; Godin, Stephen J; Ramos, Ilyssa; Wu, Qi; Oswald, Erin; Poon, Patrick; Golubov, Jacquelynn; Grote, Devon; Stella, Jennifer; Pawashe, Arpita; Finney, Jennifer; Herlihy, Evan; Ahmed, Hassan; Kamat, Vishal; Dorvilliers, Amanda; Navarro, Elizabeth; Xiao, Jenny; Kim, Julie; Yang, Shao Ning; Warsaw, Jacqueline; Lett, Clarissa; Canova, Lauren; Schulenburg, Teresa; Foster, Randi; Krueger, Pamela; Garnova, Elena; Rafique, Ashique; Babb, Robert; Chen, Gang; Stokes Oristian, Nicole; Siao, Chia-Jen; Daly, Christopher; Gurer, Cagan; Martin, Joel; Macdonald, Lynn; MacDonald, Douglas; Poueymirou, William; Smith, Eric; Lowy, Israel; Thurston, Gavin; Olson, William; Lin, John C.

Sci Transl Med ; 12(549)2020 06 24.

Artigo em Inglês | MEDLINE | ID: mdl-32581132

10.

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.

Hansen, Johanna; Baum, Alina; Pascal, Kristen E; Russo, Vincenzo; Giordano, Stephanie; Wloga, Elzbieta; Fulton, Benjamin O; Yan, Ying; Koon, Katrina; Patel, Krunal; Chung, Kyung Min; Hermann, Aynur; Ullman, Erica; Cruz, Jonathan; Rafique, Ashique; Huang, Tammy; Fairhurst, Jeanette; Libertiny, Christen; Malbec, Marine; Lee, Wen-Yi; Welsh, Richard; Farr, Glen; Pennington, Seth; Deshpande, Dipali; Cheng, Jemmie; Watty, Anke; Bouffard, Pascal; Babb, Robert; Levenkova, Natasha; Chen, Calvin; Zhang, Bojie; Romero Hernandez, Annabel; Saotome, Kei; Zhou, Yi; Franklin, Matthew; Sivapalasingam, Sumathi; Lye, David Chien; Weston, Stuart; Logue, James; Haupt, Robert; Frieman, Matthew; Chen, Gang; Olson, William; Murphy, Andrew J; Stahl, Neil; Yancopoulos, George D; Kyratsous, Christos A.

Science ; 369(6506): 1010-1014, 2020 08 21.

Artigo em Inglês | MEDLINE | ID: mdl-32540901

11.

Low back pain recovery.

Babb, Robert.

Rehab Manag ; 22(5): 22-3, 2009 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-19637677

12.

A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells.

Cruz, Jonathan W; Damko, Ermelinda; Modi, Bhavika; Tu, Naxin; Meagher, Karoline; Voronina, Vera; Gartner, Hans; Ehrlich, George; Rafique, Ashique; Babb, Robert; Aneja, Priya; Potocky, Terra B; D' Orvilliers, Amanda; Coppi, Alida; E, Sook Yen; Qiu, Haibo; Williams, Courtney M; Bennett, Brandy L; Chen, Gang; Macdonald, Lynn; Olson, William; Lin, John C; Stahl, Neil; Murphy, Andrew J; Kyratsous, Christos A; Prasad, Brinda C.

Sci Rep ; 9(1): 12031, 2019 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-31427700

13.

Creating a business backbone. A first person recount of the planning process involved in laying the foundation of a successful rehabilitation clinic.

Babb, Robert W.

Rehab Manag ; 20(1): 54, 56, 58 passim, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17310901

14.

Weekend warriors: staying in the game. How to keep functionally active for years to come.

Babb, Robert.

Rehab Manag ; 22(9): 10, 12-4, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-20329660

15.

New year, new cost constraints.

Babb, Robert; Brasser, Bruce A; Hosack, Kenneth R; Severe, Ellen; Stone, Kevin.

Rehab Manag ; 22(1): 26, 28-31, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19323100

16.

SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain.

Babb, Robert; Bowen, Benjamin R.

Biochem J ; 370(Pt 2): 719-27, 2003 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-12444922

17.

An mRNA splice variant of the AFX gene with altered transcriptional activity.

Yang, Zhenyu; Whelan, James; Babb, Robert; Bowen, Benjamin R.

J Biol Chem ; 277(10): 8068-75, 2002 Mar 08.

Artigo em Inglês | MEDLINE | ID: mdl-11779849

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