Detalhe da pesquisa
1.
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc Natl Acad Sci U S A
; 121(15): e2317274121, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579010
2.
Neuroprotective and Disease-Modifying Effects of the Triazinetrione ACD856, a Positive Allosteric Modulator of Trk-Receptors for the Treatment of Cognitive Dysfunction in Alzheimer's Disease.
Int J Mol Sci
; 24(13)2023 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446337
3.
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.
Bioorg Med Chem
; 29: 115859, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33309749
4.
A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes.
Bioorg Med Chem Lett
; 28(3): 519-522, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29279275
5.
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands.
Eur J Med Chem
; 265: 116122, 2024 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38199164
6.
Imitation of ß-lactam binding enables broad-spectrum metallo-ß-lactamase inhibitors.
Nat Chem
; 14(1): 15-24, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34903857
7.
Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media.
PLoS One
; 16(9): e0244910, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34469447
8.
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
Clin Pharmacol Ther
; 109(4): 1063-1073, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33150591
9.
A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode.
ChemistryOpen
; 8(1): 114-125, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30697513
10.
Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.
J Med Chem
; 61(9): 4189-4202, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29608068
11.
A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
J Pharm Sci
; 106(9): 2909-2913, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28450237
12.
Regulation of aryl hydrocarbon receptor signal transduction by protein tyrosine kinases.
Cell Signal
; 17(1): 39-48, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15451023
13.
Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9.
J Pharm Sci
; 105(2): 1017-1021, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26869442
14.
Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29.
Gene
; 285(1-2): 127-39, 2002 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12039039
15.
The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis.
Pigment Cell Melanoma Res
; 23(6): 828-33, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20973933
16.
Different structural requirements of the ligand binding domain of the aryl hydrocarbon receptor for high- and low-affinity ligand binding and receptor activation.
Mol Pharmacol
; 65(2): 416-25, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14742684
17.
Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1.
Biochem Biophys Res Commun
; 315(3): 679-85, 2004 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-14975754