RESUMO
Intratumoral injections of 10 mg cells walls from Propionibacterium granulosum strain KP-45 (PG) were applied in 14 patients with advanced, metastatic stomach (five cases) and colorectal (nine cases) adenocarcinoma. Each patient had his own "twin" control. All patients received no other anticancer treatment, except analgetics and/or palliative surgery. Treatment with PG resulted in partial regression of tumors accompanied by improvement of the clinical state of these patients as well as the reappearance of normal values in blood count biochemical parameters. In each pair of twin cases, survival of the PG-treated patient was longer than the untreated control. The mean survival of PG-treated patients was 23.5 months (4 of 14 patients being still alive after 2.5 years follow-up), while all control patients died with a mean survival period of 6.4 months. The difference between these two patient groups of about 17 months is significant (p greater than 0.01).
Assuntos
Adenocarcinoma/terapia , Vacinas Bacterianas/uso terapêutico , Neoplasias Intestinais/terapia , Propionibacterium/imunologia , Neoplasias Gástricas/terapia , Adulto , Feminino , Seguimentos , Humanos , Neoplasias Intestinais/sangue , Neoplasias Intestinais/patologia , Contagem de Leucócitos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Neoplasias Gástricas/sangue , Neoplasias Gástricas/patologiaRESUMO
The studies aiming at evaluation of immunity after splenectomy, splenic artery ligation, and autotransplantation of splenic tissue were performed in sheep. It was found that splenectomy alters both humoral and cellular immunity. The phagocytic activity of granulocytes, reduced level of IgG, drop in T and ARF cells as well as bone marrow stimulation were noted. In animals subjected to splenic artery ligation or autotransplantation of splenic tissue no significant differences in parameters studied were observed. These results correlated with histological examinations indicate that in the case of spleen trauma two important steps should be followed: the spleen, if possible, should be saved or a spleen saving procedure should be employed; in case of extensive trauma or if contraindications for spleen saving exist, autotransplantation of splenic tissue should be performed.
Assuntos
Baço/imunologia , Esplenectomia , Animais , Formação de Anticorpos , Autoanticorpos/imunologia , Eritrócitos/imunologia , Granulócitos/imunologia , Imunidade Celular , Ligadura , Fagocitose , Contagem de Plaquetas , Formação de Roseta , Baço/lesões , Baço/transplante , Artéria Esplênica/cirurgia , Staphylococcus aureus/imunologiaRESUMO
Five years ago, in a 34-year-old female patient a tumour developed in the right supraclavicular fossa which gradually increased in size. A few months ago she had noticed also a tumour in the axillary fossa on the same side. On physical examination, USG, and contrast X-ray it was found that it was a cyst of hour-glass shape (narrowing of retro-clavicular). The cyst was removed totally. Histological examination: cystic lymphangioma (hygroma). The aetiology, diagnosis, and treatment of this type of tumours are discussed.