Human papillomavirus infection and cardiovascular mortality: a cohort study.

BACKGROUND AND AIMS: High-risk human papillomavirus (HR-HPV) infection-a well-established risk factor for cervical cancer-has associations with cardiovascular disease (CVD). However, its relationship with CVD mortality remains uncertain. This study examined the associations between HR-HPV infection and CVD mortality. METHODS: As part of a health examination, 163 250 CVD-free Korean women (mean age: 40.2 years) underwent HR-HPV screening and were tracked for up to 17 years (median: 8.6 years). National death records identified the CVD mortality cases. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD mortality were estimated using Cox proportional hazard regression analyses. RESULTS: During 1 380 953 person-years of follow-up, 134 CVD deaths occurred, with a mortality rate of 9.1 per 105 person-years for HR-HPV(-) women and 14.9 per 105 person-years for HR-HPV(+) women. After adjustment for traditional CVD risk factors and confounders, the HRs (95% CI) for atherosclerotic CVD (ASCVD), ischaemic heart disease (IHD), and stroke mortality in women with HR-HPV infection compared with those without infection were 3.91 (1.85-8.26), 3.74 (1.53-9.14), and 5.86 (0.86-40.11), respectively. The association between HR-HPV infection and ASCVD mortality was stronger in women with obesity than in those without (P for interaction = .006), with corresponding HRs (95% CI) of 4.81 (1.55-14.93) for obese women and 2.86 (1.04-7.88) for non-obese women. CONCLUSIONS: In this cohort study of young and middle-aged Korean women, at low risks for CVD mortality, those with HR-HPV infection had higher death rates from CVD, specifically ASCVD and IHD, with a more pronounced trend in obese individuals.

A shift from chemical oxygen demand to total organic carbon for stringent industrial wastewater regulations: Utilization of organic matter characteristics.

From 2022, industrial wastewater discharge regulations in South Korea will replace chemical oxygen demand (CODMn) with total organic carbon (TOC). A shift from CODMn to TOC is a pioneering change in protecting water bodies from organic contaminants. However, several industries are struggling to meet these TOC requirements even though their effluents met the CODMn limits. Effluent CODMn/TOC ratios (1.28 ± 0.64) found in our study were lower than the CODMn/TOC coefficients (1.33-1.80) suggested by the Ministry of Environment in South Korea. Aliphatic and particulate organic matter contents in effluents likely influenced the CODMn/TOC ratio. Regardless of the industrial category, dissolved organic carbon often consists of low molecular weight neutrals, hydrophobic organic carbon, and protein-like substances in raw and treated industrial wastewaters. The present study also revealed that TOC and CODMn represented different organic matter fractions in the paper mill and oil refinery wastewater, whereas the industrial park wastewater showed similar dissolved organic matter characteristics. Specifically, CODMn was effective in the determination of humic content in paper mill wastewater but was underestimated in oil refinery wastewater. Additionally, only paper mill effluents exceeded the TOC requirements (4 of 6 samples) and required an additional post-treatment process owing to higher organic loads.