Detalhe da pesquisa
1.
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Bioorg Med Chem
; 28(1): 115232, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31818630
2.
The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation.
J Biol Chem
; 292(13): 5610-5621, 2017 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28167536
3.
A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation.
Cancer Discov
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38691346
4.
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
J Med Chem
; 63(13): 6679-6693, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32250617
5.
The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Cancer Discov
; 10(1): 54-71, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31658955
6.
Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition.
Chem Res Toxicol
; 22(7): 1298-309, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19445523
7.
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
ACS Med Chem Lett
; 9(12): 1230-1234, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613331
8.
Discovery of 2-pyridylureas as glucokinase activators.
J Med Chem
; 57(19): 8180-6, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25203462
9.
Characterization of a novel glucokinase activator in rat and mouse models.
PLoS One
; 9(2): e88431, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24533087
10.
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.
ACS Med Chem Lett
; 5(12): 1284-9, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25516785
11.
Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation.
Chem Res Toxicol
; 20(6): 954-64, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17497897
12.
Mechanism of formation of the ester linkage between heme and Glu310 of CYP4B1: 18O protein labeling studies.
Biochemistry
; 46(41): 11598-605, 2007 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17880109
13.
CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism.
Drug Metab Rev
; 38(3): 451-76, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16877261
14.
Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.
Chem Res Toxicol
; 18(5): 855-64, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15892579
15.
Sites of covalent attachment of CYP4 enzymes to heme: evidence for microheterogeneity of P450 heme orientation.
Biochemistry
; 44(42): 13914-20, 2005 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16229480
16.
Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate.
Biochemistry
; 42(15): 4601-6, 2003 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12693958
17.
Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group.
Arch Biochem Biophys
; 416(1): 17-24, 2003 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12859977