Detalhe da pesquisa
1.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature
; 550(7677): 481-486, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29045389
2.
Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN).
Bioorg Med Chem Lett
; 29(8): 1001-1006, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30803804
3.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556090
4.
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg Med Chem Lett
; 24(1): 337-43, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24279990
5.
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(17): 4875-85, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23899614
6.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(20): 5488-97, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24021463
7.
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg Med Chem Lett
; 23(12): 3531-8, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23668988
8.
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
Cancer Cell
; 6(1): 33-43, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15261140
9.
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.
J Med Chem
; 62(14): 6575-6596, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31199148
10.
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
J Med Chem
; 59(18): 8345-68, 2016 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27541271
11.
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
J Med Chem
; 45(4): 753-7, 2002 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11831887
12.
N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).
J Med Chem
; 46(21): 4609-24, 2003 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14521422
13.
Structural basis for resistance to diverse classes of NAMPT inhibitors.
PLoS One
; 9(10): e109366, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25285661
14.
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
J Med Chem
; 57(3): 770-92, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24405419
15.
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
J Med Chem
; 56(12): 4921-37, 2013 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23617784
16.
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J Med Chem
; 56(16): 6413-33, 2013 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23859118
17.
Hairpin versus extended DNA binding of a substituted beta-alanine linked polyamide.
J Am Chem Soc
; 124(10): 2148-52, 2002 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-11878968
18.
Synthesis and DNA binding properties of saturated distamycin analogues.
Bioorg Med Chem Lett
; 12(18): 2647-50, 2002 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12182879
19.
Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase.
J Org Chem
; 68(10): 3866-73, 2003 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12737565
20.
Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.
J Biol Chem
; 278(52): 52964-71, 2003 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14534293