Detalhe da pesquisa
1.
Challenges and recent progress in drug discovery for tropical diseases.
Nature
; 559(7715): 498-506, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046073
2.
Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Nucleic Acids Res
; 49(9): 5351-5368, 2021 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33885823
3.
High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria.
Antimicrob Agents Chemother
; 66(6): e0023722, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35647647
4.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc Natl Acad Sci U S A
; 116(14): 7015-7020, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894487
5.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
6.
Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity.
Malar J
; 18(1): 392, 2019 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31796083
7.
Screening a protein kinase inhibitor library against Plasmodium falciparum.
Malar J
; 16(1): 446, 2017 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29115999
8.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
9.
Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium.
Front Cell Infect Microbiol
; 13: 1236814, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37600947
10.
Design of the Global Health chemical diversity library v2 for screening against infectious diseases.
PLoS Negl Trop Dis
; 17(12): e0011799, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38150490
11.
Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022.
ACS Infect Dis
; 9(5): 1046-1055, 2023 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37083395
12.
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
J Med Chem
; 66(22): 15380-15408, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37948640
13.
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.
ACS Infect Dis
; 8(9): 1962-1974, 2022 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037410
14.
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Cell Chem Biol
; 29(2): 191-201.e8, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34348113
15.
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Nat Commun
; 13(1): 5992, 2022 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220877
16.
ß-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.
Bioorg Med Chem
; 19(7): 2378-91, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21411327
17.
MalDA, Accelerating Malaria Drug Discovery.
Trends Parasitol
; 37(6): 493-507, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33648890
18.
Prioritization of Molecular Targets for Antimalarial Drug Discovery.
ACS Infect Dis
; 7(10): 2764-2776, 2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34523908
19.
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.
Bioorg Med Chem Lett
; 20(15): 4364-6, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615694
20.
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
ChemMedChem
; 14(14): 1329-1335, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31188540