Detalhe da pesquisa
1.
Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities.
Proc Natl Acad Sci U S A
; 116(9): 3774-3783, 2019 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30808763
2.
Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate.
Int J Mol Sci
; 20(5)2019 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30841526
3.
Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.
Int J Mol Sci
; 18(7)2017 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28640209
4.
Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin.
J Nat Prod
; 79(8): 2113-21, 2016 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27518758
5.
Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones.
Arch Pharm (Weinheim)
; 349(9): 749-61, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27404773
6.
Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F-Actin.
J Org Chem
; 80(17): 8511-9, 2015 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26079383
7.
The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin.
Arch Pharm (Weinheim)
; 348(8): 541-7, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085125
8.
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Bioorg Med Chem
; 22(18): 5078-90, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25047938
9.
Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring.
Org Biomol Chem
; 11(35): 5809-26, 2013 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23892508
10.
Tannic Acid and Ethyl Gallate Potentialize Paclitaxel Effect on Microtubule Dynamics in Hep3B Cells.
Pharmaceuticals (Basel)
; 16(11)2023 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38004444
11.
Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.
Biochemistry
; 51(1): 329-41, 2012 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148836
12.
Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.
Bioorg Med Chem Lett
; 22(24): 7693-6, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23103097
13.
Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.
Bioorg Med Chem Lett
; 21(16): 4852-6, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21764308
14.
CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement.
Dev Cell
; 56(23): 3264-3275.e7, 2021 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34672971
15.
Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity.
Chembiochem
; 11(12): 1669-78, 2010 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20665616
16.
Structural model for differential cap maturation at growing microtubule ends.
Elife
; 92020 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151315
17.
Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.
Chem Biol
; 15(6): 573-85, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18559268
18.
Synthesis and biological activities of high affinity taxane-based fluorescent probes.
Bioorg Med Chem Lett
; 19(3): 751-4, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19128972
19.
Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia.
iScience
; 21: 95-109, 2019 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31655259
20.
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Eur J Med Chem
; 162: 290-320, 2019 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30448418