Detalhe da pesquisa
1.
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Nature
; 531(7594): 381-5, 2016 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26934220
2.
Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent.
Antimicrob Agents Chemother
; 65(2)2021 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33229429
3.
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
Bioorg Med Chem Lett
; 29(16): 2428-2436, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31133531
4.
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg Med Chem Lett
; 27(8): 1840-1847, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28274633
5.
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.
Antimicrob Agents Chemother
; 60(2): 806-17, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26596942
6.
Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir.
Biochim Biophys Acta
; 1840(12): 3292-8, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25139683
7.
Discovery of ß-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases.
Bioorg Med Chem Lett
; 25(12): 2484-7, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978965
8.
Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides.
Org Biomol Chem
; 13(35): 9300-13, 2015 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26239898
9.
Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Antimicrob Agents Chemother
; 58(4): 1930-42, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24419349
10.
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
ACS Med Chem Lett
; 11(3): 358-364, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184970
11.
In vitro selection of resistance to sofosbuvir in HCV replicons of genotype-1 to -6.
Antivir Ther
; 22(7): 587-597, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28248189
12.
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs.
PLoS One
; 12(10): e0185998, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29020100
13.
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.
PLoS One
; 12(8): e0181969, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28809961
14.
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
J Med Chem
; 60(5): 1648-1661, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28124907
15.
Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase.
Science
; 347(6223): 771-5, 2015 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25678663
16.
Structural and regulatory elements of HCV NS5B polymerase--ß-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.
PLoS One
; 9(1): e84808, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24416288
17.
Secretory leukocyte protease inhibitor binds to Neisseria gonorrhoeae outer membrane opacity protein and is bactericidal.
Am J Reprod Immunol
; 68(2): 116-27, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22537232