1.
Nucleosides Nucleotides Nucleic Acids
; 22(5-8): 1003-6, 2003.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14565331
RESUMO
In order to improve the oral bioavailability of LdC, valinyl esters were prepared as prodrugs. We report here the syntheses of the 3'-mono-, 5'-mono, and 3',5'-di-O-valinyl esters of LdC. The comparison of their ease of synthesis, their physicochemical properties, as well as their pharmacokinetic parameters in cynomologus monkeys has revealed 3'-mono-O-valinyl derivative as the most promising of the studied prodrugs. This compound is being developed as a new anti-HBV agent.