Detalhe da pesquisa
1.
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Nature
; 615(7953): 678-686, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922586
2.
A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Nature
; 598(7881): 504-509, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34616043
3.
Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Nature
; 599(7883): E2, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34671169
4.
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication.
Molecules
; 27(3)2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35164317
5.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33813272
6.
Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.
J Antimicrob Chemother
; 73(7): 1823-1829, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29596680
7.
Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.
J Med Chem
; 67(5): 4063-4082, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38482827
8.
Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.
J Med Chem
; 66(13): 8808-8821, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37389813
9.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
mBio
; 14(1): e0281522, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625640
10.
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.
Nat Chem Biol
; 6(6): 442-8, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20473303
11.
Identification of fungicidal 2,6-disubstituted quinolines with activity against Candida biofilms.
Molecules
; 17(10): 12243-51, 2012 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23079495
12.
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.
Antiviral Res
; 187: 105020, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515606
13.
Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors.
J Med Chem
; 61(18): 8390-8401, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30149709
14.
2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.
Antivir Chem Chemother
; 18(4): 225-42, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17907380
15.
2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents.
J Med Chem
; 58(3): 1502-12, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25585716