RESUMO
In 18 persons (anaesthetists and anaesthetic nurses) with a history of long-term exposure to low concentrations of halothane the activity of aminotransferases, GGTP, and alkaline phosphatase, the bilirubin level and thymol turbidity test were determined and no significant abnormalities were found. On the other hand, determinations of immunoglobulons showed changes in the raised IgM level in 15 out of 18 persons, the difference between the normal level and that found in the present studies being statistically significant. The levels of IgA and IgG were within the normal range. Raised IgM level may be due to stimulation of the immune system by halothane.
Assuntos
Halotano/intoxicação , Imunoglobulinas/análise , Fígado/efeitos dos fármacos , Doenças Profissionais/induzido quimicamente , Adulto , Idoso , Fosfatase Alcalina/sangue , Anestesiologia , Bilirrubina/sangue , Exposição Ambiental , Feminino , Humanos , Imunidade/efeitos dos fármacos , Imunoglobulina A/análise , Imunoglobulina G/análise , Imunoglobulina M/análise , Masculino , Pessoa de Meia-Idade , Enfermeiros Anestesistas , Peptidil Transferases/sangue , Timol , Fatores de Tempo , Transaminases/sangueRESUMO
The reported studies were carried out on 22 persons, 15 anaesthetists and 7 anaesthetic nurses with a history of long-term exposure to halothane in low concentrations. The activity of gamma-glutamyl-transpeptidase (GGTP) and aminotransferases, the level of bilirubin and thymol turbidity test were determined. No significant abnormalities were found in the mean values of these determinations. In some cases a rise in alkaline phosphatase activity and in two cases a rise of GGTP were found. The results are not suggesting the presence of hepatocellular damage in this group.
Assuntos
Anestesiologia , Halotano/intoxicação , Fígado/efeitos dos fármacos , Doenças Profissionais/induzido quimicamente , Transferases/sangue , Adulto , Idoso , Doença Hepática Induzida por Substâncias e Drogas , Feminino , Humanos , Hepatopatias/diagnóstico , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/diagnóstico , Peptidil Transferases/sangue , Transaminases/sangue , Recursos HumanosRESUMO
Three cases of hypogammaglobulinemia are described. In all cases the first symptoms of disease manifesting as pneumonia were preceded by diarrhea. In gastric biopsy there was atrophic gastritis with lack of plasmocytes. All patients demonstrated gastric achylia and symptoms of malabsorption syndrome. The causes of gastrointestinal changes, most probably infections, with simultaneous defective mucosal barrier are discussed.