Detalhe da pesquisa
1.
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Nucleic Acids Res
; 37(9): 2867-81, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19282453
2.
Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2'-alkoxy modified oligonucleotides.
Biochemistry
; 46(19): 5635-46, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17411072
3.
Five- and six-membered conformationally locked 2',4'-carbocyclic ribo-thymidines: synthesis, structure, and biochemical studies.
J Am Chem Soc
; 129(26): 8362-79, 2007 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17552524
4.
Synthesis and structure of novel conformationally constrained 1',2'-azetidine-fused bicyclic pyrimidine nucleosides: their incorporation into oligo-DNAs and thermal stability of the heteroduplexes.
J Org Chem
; 71(1): 299-314, 2006 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16388649
5.
Non-identical electronic characters of the internucleotidic phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds.
Org Biomol Chem
; 4(5): 928-41, 2006 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16493477
6.
Conformationally constrained 2'-N,4'-C-ethylene-bridged thymidine (aza-ENA-T): synthesis, structure, physical, and biochemical studies of aza-ENA-T-modified oligonucleotides.
J Am Chem Soc
; 128(47): 15173-87, 2006 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17117869
7.
Facile preparation of the oxetane-nucleosides.
Org Biomol Chem
; 3(24): 4362-72, 2005 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16327897
8.
Significant pKa perturbation of nucleobases is an intrinsic property of the sequence context in DNA and RNA.
J Am Chem Soc
; 126(28): 8674-81, 2004 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15250719