UniProt and Mass Spectrometry-Based Proteomics-A 2-Way Working Relationship.

The human proteome comprises of all of the proteins produced by the sequences translated from the human genome with additional modifications in both sequence and function caused by nonsynonymous variants and posttranslational modifications including cleavage of the initial transcript into smaller peptides and polypeptides. The UniProtKB database (www.uniprot.org) is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information and presents a summary of experimentally verified, or computationally predicted, functional information added by our expert biocuration team for each protein in the proteome. Researchers in the field of mass spectrometry-based proteomics both consume and add to the body of data available in UniProtKB, and this review highlights the information we provide to this community and the knowledge we in turn obtain from groups via deposition of large-scale datasets in public domain databases.

Glass-ceramic-mediated, magnetic-field-induced localized hyperthermia: response of a murine mammary carcinoma.

Hyperthermia has been found to be a useful modality for cancer therapy. In this report, a biocompatible, ferrimagnetic glass-ceramic capable of inducing localized hyperthermia by hysteresis heating upon exposure to an alternating magnetic field is presented. When the glass-ceramic was placed in the region of a subcutaneously transplanted, weakly antigenic breast carcinoma and subjected to the magnetic field, sufficient temperature rise was obtained to cause significant (approximately 50%) tumor regrowth delay and a 12% permanent control. The data demonstrate that glass-ceramic-mediated hysteresis heating may be a useful therapeutic approach in the treatment of cancer which offers the advantage of producing a highly localized and predictable tumor volume hyperthermia.

Scatter-ratio test for lens surface-quality measurement.

The surface quality of an optical lens can be quantitatively measured using a scatter ratio test. A collimated light beam is focused by the test lens upon an opaque spot. A detector behind the spot measures light scattered past the spot. The spot is then displaced to the side so that total energy out of the lens is measured by the detector. The scatter ratio is the ratio of the two detector outputs. The test is shown to be reproducible and insensitive to operator effects. It is shown to be an effective process control tool for detecting changes in surface finish. The relationship between stylus measurements of lens surface roughness and the scatter ratios is shown.