Detalhe da pesquisa
1.
X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitors.
Bioorg Med Chem Lett
; 20(17): 5217-20, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655210
2.
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
J Med Chem
; 56(1): 345-56, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23214979
3.
Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci
; 20(2): 428-36, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21280133
4.
Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation.
Chem Biol Drug Des
; 76(2): 154-63, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20545945
5.
Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes.
Chem Biol Drug Des
; 73(4): 466-70, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19220318
6.
The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells.
Mol Immunol
; 46(7): 1458-66, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19181383
7.
Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations.
J Immunol
; 178(5): 2641-5, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17312103