Detalhe da pesquisa
1.
Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis.
Antimicrob Agents Chemother
; 68(4): e0156223, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38376228
2.
Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection.
Antimicrob Agents Chemother
; 67(2): e0145922, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36688684
3.
A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity.
Antimicrob Agents Chemother
; 95(5)2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558292
4.
Living with tuberculosis: a qualitative study of patients' experiences with disease and treatment.
BMC Public Health
; 22(1): 1717, 2022 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36085073
5.
A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(12): e0151421, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606340
6.
First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment.
Antimicrob Agents Chemother
; 63(8)2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182528
7.
Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.
Bioorg Med Chem Lett
; 28(22): 3529-3533, 2018 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30316633
8.
High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 59(1): 693-7, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25348525
9.
Combinations of ß-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection.
Antimicrob Agents Chemother
; 59(8): 4997-9, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25987618
10.
ß-Lactams against Tuberculosis--New Trick for an Old Dog?
N Engl J Med
; 375(4): 393-4, 2016 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27433841
11.
Identification of ß-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.
ACS Infect Dis
; 8(3): 557-573, 2022 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35192346
12.
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Sci Transl Med
; 14(643): eaaz6280, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507672
13.
MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis.
J Med Chem
; 63(9): 4732-4748, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32275415
14.
Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis.
ACS Med Chem Lett
; 10(10): 1423-1429, 2019 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620228
15.
In vivo potent BM635 analogue with improved drug-like properties.
Eur J Med Chem
; 145: 539-550, 2018 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29335214
16.
Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Nat Commun
; 9: 16227, 2018 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004092
17.
Pharmaceutical salt of BM635 with improved bioavailability.
Eur J Pharm Sci
; 99: 17-23, 2017 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27939618
18.
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Nat Commun
; 8: 16081, 2017 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714473
19.
The Tuberculosis Drug Accelerator at year 10: what have we learned?
Nat Med
; 27(8): 1333-1337, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34226736
20.
Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-ß-d-ribose Oxidase.
ACS Infect Dis
; 1(12): 615-26, 2015 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27623058