Detalhe da pesquisa
1.
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Cell
; 166(4): 935-949, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27477512
2.
mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.
Mol Cell
; 71(5): 675-688.e6, 2018 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30193095
3.
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Brain
; 147(5): 1784-1798, 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387080
4.
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
EMBO J
; 39(17): e104671, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32757223
5.
Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues.
Mol Med
; 30(1): 36, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38459427
6.
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.
Mol Cell
; 62(2): 272-283, 2016 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27151442
7.
Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics.
Brain
; 145(12): 4409-4424, 2022 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35793238
8.
Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction.
FASEB J
; 34(6): 8139-8154, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32329133
9.
Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.
Int J Mol Sci
; 22(16)2021 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34445621
10.
Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly.
J Biol Chem
; 294(1): 257-268, 2019 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30401748
11.
MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.
Acta Neuropathol
; 140(1): 63-80, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32306066
12.
Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues.
Mol Med
; 30(1): 49, 2024 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38600455
13.
Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.
J Neurosci Res
; 97(12): 1590-1605, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31282030
14.
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Genome Res
; 25(5): 701-13, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25908449
15.
RNA Related Pathology in Huntington's Disease.
Adv Exp Med Biol
; 1049: 85-101, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29427099
16.
HDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophy.
PLoS Genet
; 11(3): e1005021, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25748626
17.
Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific.
Glia
; 65(1): 50-61, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27615381
18.
Dysfunction of the CNS-heart axis in mouse models of Huntington's disease.
PLoS Genet
; 10(8): e1004550, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25101683
19.
Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders.
Hum Mol Genet
; 23(14): 3641-56, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24556212
20.
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
PLoS Biol
; 11(11): e1001717, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24302884