Detalhe da pesquisa
1.
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Diabetologia
; 66(4): 674-694, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36633628
2.
Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells.
Diabetologia
; 57(12): 2535-45, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25208758
3.
RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells.
Diabetes
; 73(3): 448-460, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38064570
4.
A role and mechanism for redox sensing by SENP1 in ß-cell responses to high fat feeding.
Nat Commun
; 15(1): 334, 2024 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38184650
5.
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.
Nat Genet
; 55(1): 54-65, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36543916
6.
Impacts of the COVID-19 pandemic on a human research islet program.
Islets
; 14(1): 101-113, 2022 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-35285768
7.
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress.
Sci Adv
; 8(40): eabo3932, 2022 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36197983
8.
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Cell Metab
; 34(2): 256-268.e5, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35108513
9.
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Nat Commun
; 13(1): 735, 2022 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35136059
10.
ß-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice.
Diabetes
; 70(11): 2626-2638, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34462260
11.
Improved glucose tolerance with DPPIV inhibition requires ß-cell SENP1 amplification of glucose-stimulated insulin secretion.
Physiol Rep
; 8(8): e14420, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32339440
12.
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes.
Cell Metab
; 31(5): 1017-1031.e4, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302527
13.
A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets.
Physiol Rep
; 7(19): e14250, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31591827
14.
A glucose-dependent spatial patterning of exocytosis in human ß-cells is disrupted in type 2 diabetes.
JCI Insight
; 52019 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085831
15.
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic ß-cells.
Nat Genet
; 50(8): 1122-1131, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30054598
16.
Cystic fibrosis-related diabetes is caused by islet loss and inflammation.
JCI Insight
; 3(8)2018 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29669939
17.
Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human ß-Cell Dysfunction.
Diabetes
; 66(7): 1890-1900, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28607108
18.
Interleukin-1 signaling contributes to acute islet compensation.
JCI Insight
; 1(4): e86055, 2016 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27699257
19.
A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human ß-Cells and Is Impaired in Type 2 Diabetes.
Diabetes
; 65(8): 2311-21, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27207556
20.
Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice.
Diabetes
; 65(2): 451-62, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26581595