Detalhe da pesquisa
1.
Advanced mass spectrometry workflows for accurate quantification of trace-level host cell proteins in drug products: Benefits of FAIMS separation and gas-phase fractionation DIA.
Proteomics
; 23(16): e2300172, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148167
2.
Benefits and Limitations of High-Resolution Cyclic IM-MS for Conformational Characterization of Native Therapeutic Monoclonal Antibodies.
Anal Chem
; 95(8): 4162-4171, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36780376
3.
Interlaboratory Evaluation of a User-Friendly Benchtop Mass Spectrometer for Multiple-Attribute Monitoring Studies of a Monoclonal Antibody.
Molecules
; 28(6)2023 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36985827
4.
NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods.
Mol Cell Proteomics
; 19(1): 11-30, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31591262
5.
Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade.
Chimia (Aarau)
; 76(1-2): 114-126, 2022 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38069757
6.
Optimized Sample Preparation and Data Processing of Data-Independent Acquisition Methods for the Robust Quantification of Trace-Level Host Cell Protein Impurities in Antibody Drug Products.
J Proteome Res
; 20(1): 923-931, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33016074
7.
Use of Ultrashort Columns for Therapeutic Protein Separations. Part 1: Theoretical Considerations and Proof of Concept.
Anal Chem
; 93(3): 1277-1284, 2021 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33332095
8.
Use of Ultra-short Columns for Therapeutic Protein Separations, Part 2: Designing the Optimal Column Dimension for Reversed-Phase Liquid Chromatography.
Anal Chem
; 93(3): 1285-1293, 2021 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33305942
9.
Therapeutic Fc-fusion proteins: Current analytical strategies.
J Sep Sci
; 44(1): 35-62, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32914936
10.
Toward Automation of Collision-Induced Unfolding Experiments through Online Size Exclusion Chromatography Coupled to Native Mass Spectrometry.
Anal Chem
; 92(19): 12900-12908, 2020 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32886492
11.
Middle Level IM-MS and CIU Experiments for Improved Therapeutic Immunoglobulin Subclass Fingerprinting.
Anal Chem
; 92(13): 8827-8835, 2020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32453570
12.
Glycan-Mediated Technology for Obtaining Homogeneous Site-Specific Conjugated Antibody-Drug Conjugates: Synthesis and Analytical Characterization by Using Complementary Middle-up LC/HRMS Analysis.
Anal Chem
; 92(12): 8170-8177, 2020 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407621
13.
Proof of Concept To Achieve Infinite Selectivity for the Chromatographic Separation of Therapeutic Proteins.
Anal Chem
; 91(20): 12954-12961, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31514494
14.
Orthogonal Middle-up Approaches for Characterization of the Glycan Heterogeneity of Etanercept by Hydrophilic Interaction Chromatography Coupled to High-Resolution Mass Spectrometry.
Anal Chem
; 91(1): 873-880, 2019 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30512936
15.
Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry.
Anal Chem
; 91(3): 2079-2085, 2019 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30571088
16.
Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future.
Expert Rev Proteomics
; 16(4): 337-362, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30706723
17.
Native Mass Spectrometry, Ion Mobility, and Collision-Induced Unfolding for Conformational Characterization of IgG4 Monoclonal Antibodies.
Anal Chem
; 90(15): 8865-8872, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29956914
18.
Development of Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry Using Hydrophilic Interaction and Reversed-Phase Separations for Rapid and Deep Profiling of Therapeutic Antibodies.
Anal Chem
; 90(9): 5923-5929, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29614857
19.
Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody.
Anal Chem
; 90(21): 12527-12535, 2018 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30252447
20.
A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants.
Anal Chem
; 90(23): 13929-13937, 2018 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30371058