Detalhe da pesquisa
1.
Investigation of TGF-α-overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates.
J Appl Toxicol
; 44(2): 272-286, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37655636
2.
A graphite furnace-atomic absorption spectrometry-based rubidium efflux assay for screening activators of the Kv 7.2/3 channel.
Arch Pharm (Weinheim)
; 356(5): e2200585, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36748851
3.
Flupirtine and retigabine as templates for ligand-based drug design of KV7.2/3 activators.
Org Biomol Chem
; 17(18): 4512-4522, 2019 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30990511
4.
Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine.
Org Biomol Chem
; 16(45): 8695-8699, 2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30403254
5.
Structure-Activity Relationships of Flupirtine Analogues for Liver Esterase-Mediated Cleavage of the 4-Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity.
ChemMedChem
; 18(14): e202300145, 2023 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37170841
6.
Sulfide Analogues of Flupirtine and Retigabine with Nanomolar KV 7.2/KV 7.3 Channel Opening Activity.
ChemMedChem
; 14(9): 952-964, 2019 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30861620
7.
Flupirtine Analogues: Explorative Synthesis and Influence of Chemical Structure on KV7.2/KV7.3 Channel Opening Activity.
ChemistryOpen
; 8(1): 41-44, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30652063