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1.
Epidemiol Infect ; 145(16): 3455-3467, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-29168445

RESUMO

Introduction An unprecedented outbreak of Ebola virus diseases (EVD) occurred in West Africa from March 2014 to January 2016. The French Institute for Public Health implemented strengthened surveillance to early identify any imported case and avoid secondary cases. METHODS: Febrile travellers returning from an affected country had to report to the national emergency healthcare hotline. Patients reporting at-risk exposures and fever during the 21st following day from the last at-risk exposure were defined as possible cases, hospitalised in isolation and tested by real-time polymerase chain reaction. Asymptomatic travellers reporting at-risk exposures were considered as contact and included in a follow-up protocol until the 21st day after the last at-risk exposure. RESULTS: From March 2014 to January 2016, 1087 patients were notified: 1053 were immediately excluded because they did not match the notification criteria or did not have at-risk exposures; 34 possible cases were tested and excluded following a reliable negative result. Two confirmed cases diagnosed in West Africa were evacuated to France under stringent isolation conditions. Patients returning from Guinea (n = 531; 49%) and Mali (n = 113; 10%) accounted for the highest number of notifications. CONCLUSION: No imported case of EVD was detected in France. We are confident that our surveillance system was able to classify patients properly during the outbreak period.


Assuntos
Surtos de Doenças , Doença pelo Vírus Ebola , Vigilância em Saúde Pública , Viagem , Adolescente , Adulto , África Ocidental/etnologia , Idoso , Idoso de 80 Anos ou mais , Surtos de Doenças/prevenção & controle , Surtos de Doenças/estatística & dados numéricos , Ebolavirus , Feminino , França/epidemiologia , Doença pelo Vírus Ebola/epidemiologia , Doença pelo Vírus Ebola/etnologia , Doença pelo Vírus Ebola/prevenção & controle , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Adulto Jovem
2.
Euro Surveill ; 19(38)2014 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-25306877

RESUMO

In March 2014, a person in their eighties who was diagnosed with extensive cellulitis due to toxigenic Corynebacterium ulcerans died from multiple organ failure. Environmental investigation also isolated C. ulcerans in biological samples from two stray cats in contact with the case. This finding provides further evidence that pets can carry toxigenic C. ulcerans and may be a source of the infection in humans.


Assuntos
Doenças do Gato/transmissão , Celulite (Flegmão)/diagnóstico , Infecções por Corynebacterium/transmissão , Corynebacterium/isolamento & purificação , Animais de Estimação/microbiologia , Idoso de 80 Anos ou mais , Animais , Antibacterianos/uso terapêutico , Doenças do Gato/microbiologia , Gatos , Celulite (Flegmão)/tratamento farmacológico , Celulite (Flegmão)/microbiologia , Infecções por Corynebacterium/diagnóstico , Infecções por Corynebacterium/tratamento farmacológico , Infecções por Corynebacterium/microbiologia , Evolução Fatal , França , Humanos , Masculino
3.
Euro Surveill ; 17(18)2012 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-22587956

RESUMO

Following a suspected virus-vaccine mismatch, the screening method was used to estimate in almost real time the influenza vaccine effectiveness (VE) against severe cases in high-risk individuals. Data on vaccination status were provided by the influenza severe surveillance system and data on vaccination coverage by the National Social Security Scheme. The analysis showed a decline of the vaccine effectiveness in 2011/12 (VE: 30% (95% CI: 22-39)) compared to 2010/11 (VE: 53% (95% CI: 40-67)).


Assuntos
Surtos de Doenças/prevenção & controle , Vírus da Influenza A Subtipo H3N2/isolamento & purificação , Vacinas contra Influenza/administração & dosagem , Influenza Humana/prevenção & controle , Idoso , Surtos de Doenças/estatística & dados numéricos , Feminino , França/epidemiologia , Humanos , Influenza Humana/epidemiologia , Influenza Humana/virologia , Unidades de Terapia Intensiva , Masculino , Avaliação de Programas e Projetos de Saúde , Fatores de Risco , Estações do Ano , Vigilância de Evento Sentinela , Vacinação/estatística & dados numéricos
4.
Epidemiol Infect ; 139(10): 1637-41, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21396150

RESUMO

In December 2008, three hospitalized cases of suspected psittacosis infection were notified by respiratory disease clinicians from a local hospital to the Regional Epidemiology Unit of Pays de la Loire, France. They all had attended a bird fair. A retrospective cohort study was conducted among exhibitors and organizers to identify potential risk factors in relation to this fair. Environmental and veterinary investigations were implemented to trace potential sources of infection. We identified two confirmed, two probable and 44 possible cases among participants. The attack rate in exhibitors and organizers was 38% (33/86). The median incubation period was 11 days (range 6-22 days). Individuals located in two particular sectors of the showroom were found to be at double the risk of developing psittacosis (relative rate 2·1, 95% confidence interval 1·03-4·18) than those in other sectors. Pooled faecal samples of birds belonging to a possible case exhibitor tested positive for Chlamydiaceae by PCR. Ventilation conditions in the showroom were inadequate. This investigation allowed the formulation of recommendations to prevent psittacosis in bird exhibitions which are held weekly in France.


Assuntos
Surtos de Doenças , Psitacose/epidemiologia , Zoonoses/epidemiologia , Animais , Aves/microbiologia , Chlamydiaceae/genética , Chlamydiaceae/isolamento & purificação , Estudos de Coortes , DNA Bacteriano/genética , Microbiologia Ambiental , Fezes/microbiologia , Feminino , França/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Estudos Retrospectivos
5.
Euro Surveill ; 16(19)2011 May 12.
Artigo em Inglês | MEDLINE | ID: mdl-21596008

RESUMO

In March 2011, a 40 year-old French man was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae. Fifty-three close contacts were identified from whom throat samples were analysed. C. diphtheriae was found only in the asymptomatic partner of the index case. The two cases had travelled in Spain during the incubation period of the index case. Investigation around the second case identified 13 new close contacts.None of them was found to be infected.


Assuntos
Corynebacterium diphtheriae/isolamento & purificação , Difteria/diagnóstico , Adulto , Busca de Comunicante , Difteria/tratamento farmacológico , Notificação de Doenças , França , Humanos , Masculino
6.
Med Mal Infect ; 50(7): 617-619, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32659333

RESUMO

OBJECTIVES AND METHOD: We conducted a prospective study in 2013 to compare the whole-cell versus acellular pertussis vaccines effectiveness and duration of protection, following the occurrence of pertussis clusters. RESULTS: During seven school outbreaks, we identified 102 clinical pertussis cases, including 10 cases biologically confirmed by Bordetella pertussis specific PCR, among a cohort of 305 children in 2nd to 6th grade. The risk of pertussis when vaccinated with an acellular vaccine alone was 1.6 (RR=1.6; 95% CI=1.1-2.5) times higher than when vaccinated with a whole-cell vaccine or using a combined schedule. CONCLUSIONS: The limited duration of protection conferred by the acellular vaccine reinforces the 2013 introduction of the pertussis booster at six years old.


Assuntos
Surtos de Doenças , Vacina contra Coqueluche/imunologia , Coqueluche/epidemiologia , Coqueluche/prevenção & controle , Criança , Pré-Escolar , França/epidemiologia , Humanos , Lactente , Estudos Prospectivos , Instituições Acadêmicas , Vacinas Acelulares
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