Detalhe da pesquisa
1.
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Bioorg Med Chem
; 67: 116833, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35605346
2.
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.
Nature
; 527(7577): 245-8, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26536115
3.
Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.
J Org Chem
; 82(19): 10376-10387, 2017 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28877441
4.
Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.
Drug Metab Dispos
; 44(6): 809-20, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27029743
5.
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.
Nature
; 465(7294): 96-100, 2010 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20410884
6.
Synergistic Activity of Combined NS5A Inhibitors.
Antimicrob Agents Chemother
; 60(3): 1573-83, 2015 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26711745
7.
HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.
Bioorg Med Chem Lett
; 23(15): 4428-35, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23803586
8.
HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies.
Bioorg Med Chem Lett
; 23(3): 779-84, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23273521
9.
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
J Med Chem
; 66(3): 1941-1954, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719971
10.
HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.
Bioorg Med Chem Lett
; 22(19): 6063-6, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22959243
11.
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
ACS Med Chem Lett
; 13(6): 972-980, 2022 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35707159
12.
The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.
J Gen Virol
; 92(Pt 11): 2502-2511, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21795470
13.
Developments in antiviral drug design, discovery and development in 2004.
Curr Drug Targets Infect Disord
; 5(4): 307-400, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16535860
14.
Discovery of daclatasvir, a pan-genotypic hepatitis C virus NS5A replication complex inhibitor with potent clinical effect.
J Med Chem
; 57(12): 5057-71, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24749835
15.
Discovery and development of hepatitis C virus NS5A replication complex inhibitors.
J Med Chem
; 57(5): 1643-72, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24621191
16.
HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity.
J Med Chem
; 57(5): 1976-94, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23573957
17.
Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.
J Med Chem
; 57(5): 1995-2012, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24437689
18.
Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.
J Med Chem
; 57(5): 2013-32, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24521299
19.
Characterizations of HCV NS5A replication complex inhibitors.
Virology
; 444(1-2): 343-54, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23896639
20.
Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors.
Bioorg Med Chem Lett
; 17(15): 4284-9, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17540562