The signature of undetected change: an exploratory electrotomographic investigation of gradual change blindness.

Neuroimaging-based investigations of change blindness, a phenomenon in which seemingly obvious changes in visual scenes fail to be detected, have significantly advanced our understanding of visual awareness. The vast majority of prior investigations, however, utilize paradigms involving visual disruptions (e.g., intervening blank screens, saccadic movements, "mudsplashes"), making it difficult to isolate neural responses toward visual changes cleanly. To address this issue in this present study, high-density EEG data (256 channel) were collected from 25 participants using a paradigm in which visual changes were progressively introduced into detailed real-world scenes without the use of visual disruption. Oscillatory activity associated with undetected changes was contrasted with activity linked to their absence using standardized low-resolution brain electromagnetic tomography (sLORETA). Although an insufficient number of detections were present to allow for analysis of actual change detection, increased beta-2 activity in the right inferior parietal lobule (rIPL), a region repeatedly associated with change blindness in disruption paradigms, followed by increased theta activity in the right superior temporal gyrus (rSTG) was noted in undetected visual change responses relative to the absence of change. We propose the rIPL beta-2 activity to be associated with orienting attention toward visual changes, with the subsequent rise in rSTG theta activity being potentially linked with updating preconscious perceptual memory representations. NEW & NOTEWORTHY This study represents the first neuroimaging-based investigation of gradual change blindness, a visual phenomenon that has significant potential to shed light on the processes underlying visual detection and conscious perception. The use of gradual change materials is reflective of real-world visual phenomena and allows for cleaner isolation of signals associated with the neural registration of change relative to the use of abrupt change transients.

Attentional responses on an auditory oddball predict false memory susceptibility.

Attention and memory are highly integrated processes. Building on prior behavioral investigations, this study assesses the link between individual differences in low-level neural attentional responding and false memory susceptibility on the misinformation effect, a paradigm in which false event memories are induced via misleading post-event information. Twenty-four subjects completed the misinformation effect paradigm after which high-density (256-channel) EEG data was collected as they engaged in an auditory oddball task. Temporal-spatial decomposition was used to extract two attention-related components from the oddball data, the P3b and Classic Slow Wave. The P3b was utilized as an index of individual differences in salient target attentional responding while the slow wave was adopted as an index of variability in task-level sustained attention. Analyses of these components show a significant negative relationship between slow-wave responses to oddball non-targets and perceptual false memory endorsements, suggestive of a link between individual differences in levels of sustained attention and false memory susceptibility. These findings provide the first demonstrated link between individual differences in basic attentional responses and false memory. These results support prior behavioral work linking attention and false memory and highlight the integration between attentional processes and real-world episodic memory.

Long-Term Health Consequences of Movement Restrictions for Palestinians, 1987-2011.

OBJECTIVES: To estimate the long-term association between Israeli-imposed restrictions on travel for medical care in the occupied Palestinian territory and health status in adulthood. METHODS: Using event history calendar methods, we collected annual data from 1987 to 2011 from a representative sample of 1778 Palestinians aged 32 to 43 years and analyzed the subsample of whomever had a serious medical condition and needed to travel for medical care (n = 246; contributing 1163 person-years). We used ordered logistic regression with person-year data to test the association between movement restrictions from 1987 to 2011 and health status in 2011. RESULTS: Two thirds (65%; n = 161) of participants reported travel restrictions, and 38% (n = 92) reported ever being barred from travel for medical care. Compared with study participants who experienced no travel restrictions in a year (n = 559 person-years), those who were barred from travel in that same year (n = 122 person-years) reported worse self-rated health (57% vs 22% reported bad or very bad self-rated health; P < .05) and greater limits on daily functioning caused by physical health (41% vs 16% reported regular limits; P < .05). CONCLUSIONS: Being barred from travel for medical care was associated with poor health as long as 25 years later.

An exploratory high-density EEG investigation of the misinformation effect: Attentional and recollective differences between true and false perceptual memories.

The misinformation effect, a phenomenon in which eyewitness memories are altered via exposure to post-event misinformation, is one of the most important paradigms used to investigate the reconstructive nature of human memory. The aim of this study was to use the misinformation effect paradigm to investigate differences in attentional and recollective processing between true and false event memories. Nineteen participants completed a variant of the misinformation paradigm in which recognition responses to true and misinformation based event details embedded within a narrative context, were investigated using high-density (256-channel) EEG with a 1-day delay between event exposure and test. Source monitoring responses were used to isolate event-related-potentials (ERPs) associated with perceptual (i.e. event) source attributions. Temporal-spatial analyses of these ERPs showed evidence of an elevated P3b and Late-Positive Component, associated with stronger context-matching responses and recollective activity respectively, in true perceptual memories relative to false misinformation based ones. These findings represent the first retrieval focused EEG investigation of the misinformation effect and highlight the interplay between attention and retrieval processes in episodic memory recognition.

Assessing the feasibility of a life history calendar to measure HIV risk and health in older South Africans.

Life history calendars capture patterns of behavior over time, uncovering transitions and trajectories. Despite the growing numbers of older persons living with HIV in southern Africa, little is known about how HIV testing and risk unfold in this population. Operationalizing a life course approach with the use of an innovative Testing and Risk History Calendar [TRHC], we collected pilot data on older South Africans' risk and HIV testing. We found older persons were able to provide (1) reference points to facilitate recall over a 10-year period, (2) specifics about HIV tests during that decade, and (3) details that contextualize the testing data, such as living arrangements, relationships, and health status. Interviewer debriefing sessions after each interview captured information on context and links across domains. On a larger scale, the TRHC has potential to reveal pathways between sexual behavior, HIV testing and risk perception, and health at older ages.

Long-term exposure to political violence: The particular injury of persistent humiliation.

This study assessed the association between exposure to political violence over a 25-year period and adult functioning among a population that has experienced protracted and severe political conflict. Instead of aggregating exposure to political violence across time and type of exposure, as is commonly done, the event history calendar pioneered in this study assessed exposure to five forms of political violence annually from 1987 to 2011 in a representative sample of 1788 adults, aged 37 on average, in the occupied Palestinian territories (West Bank, East Jerusalem, and the Gaza Strip). This method allowed for the identification of trajectories of exposure to political violence from childhood to adulthood using latent profile analysis. We then correlated the trajectories of exposure to measures of economic, political, community, family, psychological, and health functioning. As expected, being shot at, having one's home raided, being hit or kicked, being verbally abused, and witnessing someone close being humiliated were all elevated during periods of heightened political conflict (the first intifada (1987-1993) and, less so, the second intifada (2000-2005)). In addition, 12% of women and men reported high and persistent levels of exposure to humiliation (being verbally abused and/or witnessing someone close being humiliated) across the entire 25-year period. These individuals lived predominantly in neighborhoods with a high Israeli military presence. Compared to those who experienced periodic exposure to political violence, persistently humiliated men and women reported significantly lower health, economic, political, and psychological functioning, as well as higher social cohesion and political expression. Relevant literatures are reviewed when concluding that persistent humiliation is a neglected form of political violence that is best represented as a direct (versus structural), acute (versus chronic), macro (versus micro), and high-grade (versus low-grade) stressor whose particular injury is due to the violation of individual and collective identity, rights, justice and dignity.

Utilities of dentin regeneration among insured and uninsured adults.

OBJECTIVES: This population-based study measured utilities (preferences measured under conditions of uncertainty) of dentin regeneration (DR), a potential new therapy, root canal therapy (RCT), and extraction (EXT). METHODS: A representative sample of dentate adults (aged 18-69 years) was randomly selected from the Detroit area. A computer program was used to administer the standard gamble (SG) method and record utility score (US) for treatment options of a tooth with reversible pulpitis using the SG method. For the SG method, two anchor states were used: filled tooth with full oral health and filled tooth with severe and continuous pain leading to EXT. Additional data were obtained using a self-administered questionnaire. RESULTS: Out of the 807 adults who resided in 446 screened and selected households, a final sample of 630 adults who resided in 368 households were interviewed. The mean US for DR with 75 and 95% success rates were 72.5 and 86.2 (on a 0-100 scale), respectively. The US for RCT and immediate EXT were 75.6 and 31.3, respectively. Eleven per cent of the adults valued DR with 95% success probability higher than a simple filling with full oral health for life. There were no statistically significant differences in the average US of DR between insured and uninsured adults. Factors such as gender, race, education, income and insurance status, experiences with EXTs or root canal treatment, regularity of dental visits, quality of life, and quality of oral health were not significantly associated with the scores of DR. There was, however, a small but significant interaction between race and dental insurance, and race and gender. CONCLUSION: This population-based study found that DR was highly preferred to other standard treatment options.

Willingness to pay for dentin regeneration in a sample of dentate adults.

OBJECTIVES: Measurement of individuals' valuation of dental treatments is important in the evaluation of new technologies. In this paper the value of dentin regeneration, a new treatment for teeth with reversible pulpitis, is measured based on what individuals say they would be willing to pay to receive the treatment. METHODS: A total of 611 randomly selected dentate adults answered willingness to pay (WTP) and dental insurance questions. Detailed descriptions of the process and expected outcomes for dentin regeneration were presented to subjects as part of a larger study measuring preferences for different treatments. WTP was determined for two different levels of success for dentin regeneration. RESULTS: At a success rate of 95%, the mean WTP for dentin regeneration was $262.70 (noninsured) and $11.00 per month (insured subjects). For success rate of 75%, the corresponding values were $210.90 and $9.20 per month. Multivariate analyses were used to identify any significant relationships between WTP and a range of variables covering socio-demographic, socio-economic, dental experience and oral health status variables. The findings indicate that individuals' valuations of treatments involve substantial unexplained variation. About half of the noninsured subjects would pay for dentin regeneration if it cost $200 per tooth. CONCLUSIONS: The data on the WTP for dentin regeneration indicate that a substantial percentage of adults will pay for this new technology. This study provides for the first time an estimate of WTP for dentin regeneration among the population.

Internal consistency and reliability of a questionnaire assessing organizational innovation in two schools of dentistry.

The objective of this study was to test the internal consistency and test-retest reliability of a questionnaire designed to assess the status of and factors associated with organizational innovation in schools of dentistry. The questionnaire included thirty-three questions that assessed the following six domains: innovation/environment, innovation/leadership, innovation/personal, feedback/environment, feedback/personal, and feedback/interpersonal. A seventh domain, evidence-based learning, assessed the reaction of dental faculty to a scenario where the scientific evidence found a current treatment to be ineffective in improving the health status of patients. The questionnaire was mailed three times to a systematic sample of fifty-six dental faculty working at a research-intensive dental school (RES) and all thirty-nine dental faculty working at a dental school where the emphasis is on clinical education (CL). The two U.S. dental schools had similar numbers of students; however, they differed significantly in their research portfolios. The response rate was 70.5 percent. The seven domains had alpha coefficients ranging between 0.60 and 0.89. The test-retest reliability for the seven domains ranged between 0.65 and 0.92. Dental faculty of the RES school had significantly higher average scores than faculty of the CL school on innovation/leadership, innovation/environment, feedback/environment, and feedback/personal domains. Regression analyses found no differences between the two schools in innovation/environment scores. The innovation/environment scores were significantly associated with innovation/leadership, feedback/environment, feedback/interpersonal, and age. The evidence-based learning domain was negatively associated with the innovation/environment domain, indicating that faculty who were willing to abandon teaching of a treatment found to be ineffective felt that their school environment was not highly innovative. In conclusion, this preliminary study found that the questionnaire reliably assessed six domains representing innovation and feedback. This preliminary study also found that an innovative environment in two schools of dentistry is associated with presence of leaders who promote change and innovation, an environment that encourages feedback, and faculty members who value interpersonal feedback.

Introduction: in the aftermath of the so-called memory wars.

The term "memory wars" has been used by some to characterize the intense debate that emerged in the 1990s regarding the veracity of recovered memories of child sexual abuse. Both sides in this debate have been motivated by scientific and ethical concerns. Recent years have witnessed a burgeoning of relevant behavioral and neuroimaging evidence that when taken together, points the way toward reconciliation. All of the contributors to this volume acknowledge that true recoveries characterize a substantive proportion of recovery experiences and that suggestive therapeutic techniques may promote false memories. Disagreements continue to exist on the cognitive and motivational processes that can lead to true recoveries and the extent to which false recovered memories occur.

Epilogue: continuing points of contention in the recovered memory debate.

Four contentious issues in the recovered memory debate are explored. Volume contributors offer differing perspectives on the generalizability of laboratory research, on the role of emotion in memory, on the prevalence of false recoveries, and on the motivations that underlie differences in opinion, especially with regard to whether the debate ought to be framed within a larger sociopolitical context. The recovered memory debate is argued to center on two ethical concerns that happen to be in conflict, equality among groups on one hand and due process protections on the other. Additional movement toward reconciliation is possible with a fair assessment of all available evidence, with a mutual understanding of differing perspectives, and with civil discourse.

Life-course socioeconomic position and hypertension in African American men: the Pitt County Study.

OBJECTIVES: We investigated the odds of hypertension for Black men in relationship to their socioeconomic position (SEP) in both childhood and adulthood. METHODS: On the basis of their parents' occupation, we classified 379 men in the Pitt County (North Carolina) Study into low and high childhood SEP. The men's own education, occupation, employment status, and home ownership status were used to classify them into low and high adulthood SEP. Four life-course SEP categories resulted: low childhood/low adulthood, low childhood/high adulthood, high childhood/low adulthood, and high childhood/high adulthood. RESULTS: Low childhood SEP was associated with a 60% greater odds of hypertension, and low adulthood SEP was associated with a 2-fold greater odds of hypertension. Compared with men of high SEP in both childhood and adulthood, the odds of hypertension were 7 times greater for low/low SEP men, 4 times greater for low/high SEP men, and 6 times greater for high/low SEP men. CONCLUSIONS: Greater access to material resources in both childhood and adulthood was protective against premature hypertension in this cohort of Black men. Though some parameter estimates were imprecise, study findings are consistent with both pathway and cumulative burden models of hypertension.

Retrospective data collection using event history calendars.

BACKGROUND: Event history calendars are used to collect retrospective data about events and life transitions over short and long periods of time. Event history calendars are highly structured, but flexible, approaches to interviewing respondents about past events that use their own past experiences as cues to remembering. Event history calendars incorporate autobiographical memory retrieval mechanisms to assist respondents in reconstructing past events and experiences accurately and completely. APPROACH: A sample event history calendar and experiences from an ongoing study of adolescent risk behavior are described to illustrate event history calendar methodology application in nursing research. Event history calendar design, recording, interviewing, and interviewer training descriptions are included. DISCUSSION: Event history calendars have been used extensively for retrospective data collection of occurrence, timing, and sequencing of a variety of life events in population studies, psychology, and sociology research, but not in nursing research. Because event history calendars improve recollection of complex sequences of personal events, they would be ideal for retrospective data collection in quantitative and qualitative nursing studies. Nursing expertise in history-taking make this a natural method of choice for retrospective data collection and as a means of stimulating communication during interviewing.