Detalhe da pesquisa
1.
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.
Nature
; 593(7859): 429-434, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34012082
2.
Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models.
Circulation
; 147(3): 242-253, 2023 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36314243
3.
Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery.
Circulation
; 132(23): 2248-58, 2015 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26644247
4.
A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices.
Nat Mater
; 14(10): 1065-71, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26213897
5.
Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry.
ACS Cent Sci
; 9(7): 1437-1452, 2023 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37521788
6.
GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy.
Nat Commun
; 14(1): 2776, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37188660
7.
Stressed out: the skeletal muscle ryanodine receptor as a target of stress.
J Clin Invest
; 118(2): 445-53, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18246195
8.
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.
Proc Natl Acad Sci U S A
; 105(6): 2198-202, 2008 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18268335
9.
Childhood lead poisoning: the torturous path from science to policy.
J Clin Invest
; 116(4): 853-7, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16585952
10.
Nonshivering thermogenesis protects against defective calcium handling in muscle.
FASEB J
; 22(11): 3919-24, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18687806
11.
Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits.
Circ Res
; 101(5): 465-74, 2007 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-17626895
12.
A pharmaceutical answer to nonadherence: Once weekly oral memantine for Alzheimer's disease.
J Control Release
; 303: 34-41, 2019 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30928488
13.
A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment.
Sci Transl Med
; 11(483)2019 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30867322
14.
Changing the pill: developments toward the promise of an ultra-long-acting gastroretentive dosage form.
Expert Opin Drug Deliv
; 15(12): 1189-1198, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30392404
15.
Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy.
Nat Commun
; 9(1): 2, 2018 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29317618
16.
Oral, ultra-long-lasting drug delivery: Application toward malaria elimination goals.
Sci Transl Med
; 8(365): 365ra157, 2016 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27856796
17.
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle.
Nat Med
; 15(3): 325-30, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19198614