Detalhe da pesquisa
1.
Identification of potent, selective KDM5 inhibitors.
Bioorg Med Chem Lett
; 26(17): 4350-4, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476424
2.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg Med Chem Lett
; 22(12): 4089-93, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22595176
3.
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J Med Chem
; 65(16): 11177-11186, 2022 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35930799
4.
Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors.
ACS Med Chem Lett
; 11(6): 1213-1220, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551003
5.
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Bioorg Med Chem Lett
; 19(22): 6307-12, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19819693
6.
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
J Med Chem
; 51(10): 2879-82, 2008 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18426196
7.
Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
J Med Chem
; 59(6): 2328-42, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26812066
8.
Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J Med Chem
; 59(21): 9928-9941, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27739677
9.
Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK).
J Med Chem
; 58(3): 1426-41, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25587754
10.
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.
J Med Chem
; 58(5): 2417-30, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25699405
11.
Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.
J Med Chem
; 55(5): 1858-67, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22320343
12.
Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.
J Med Chem
; 55(5): 1868-97, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22320327
13.
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
ACS Med Chem Lett
; 2(10): 758-63, 2011 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900264
14.
Correction to Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors.
J Med Chem
; 58(9): 4087, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25901648
15.
From concept to reality: the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer.
Anticancer Agents Med Chem
; 9(2): 221-9, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19199866
16.
c-Met inhibitors with different binding modes: two is better than one.
Cell Cycle
; 7(9): 1157-60, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18418040
17.
c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations.
J Biol Chem
; 283(5): 2675-83, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18055465
18.
Design, synthesis, and biological evaluation of potent c-Met inhibitors.
J Med Chem
; 51(18): 5766-79, 2008 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18763753
19.
Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458).
J Med Chem
; 51(13): 3688-91, 2008 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18553959