RESUMO
BACKGROUND: Intracranial lipomas are extremely rare fat-containing lesions, comprising 0.1-0.5% of all primary brain tumors. Lipoma of corpus callosum, the commonest variety of all intracranial lipomas (40%-50%), is associated with varying degrees of dysgenesis of corpus callosum and generally remains asymptomatic. CASE DESCRIPTION: In this study, we report 2 cases of pericallosal lipomas admitted with seizures and discuss the clinical and radiologic findings in light of the literature. CONCLUSIONS: Lipomas of the corpus callosum are rare, fat-containing asymptomatic lesions, mostly associated with dysgenesis of the corpus callosum. Diagnosis accidentally occurs during diagnostic procedures in case of an encephalic disorder. Magnetic resonance imaging is the most useful modality for a differential diagnosis. Prognosis and symptoms depend on associated malformations. Surgical treatment is mostly not indicated and should be avoided.