Detalhe da pesquisa
1.
Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial.
Eur J Neurol
; 30(1): 69-86, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36148821
2.
Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice.
Mol Ther
; 30(8): 2760-2784, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35477657
3.
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.
Acta Neuropathol
; 144(3): 437-464, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35876881
4.
Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice.
Cell Mol Life Sci
; 79(1): 7, 2021 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34936028
5.
Novel P2X7 Antagonist Ameliorates the Early Phase of ALS Disease and Decreases Inflammation and Autophagy in SOD1-G93A Mouse Model.
Int J Mol Sci
; 22(19)2021 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34638992
6.
A Novel HGF/SF Receptor (MET) Agonist Transiently Delays the Disease Progression in an Amyotrophic Lateral Sclerosis Mouse Model by Promoting Neuronal Survival and Dampening the Immune Dysregulation.
Int J Mol Sci
; 21(22)2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33198383
7.
Motor neuron degeneration, severe myopathy and TDP-43 increase in a transgenic pig model of SOD1-linked familiar ALS.
Neurobiol Dis
; 124: 263-275, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30471417
8.
A pilot trial of RNS60 in amyotrophic lateral sclerosis.
Muscle Nerve
; 59(3): 303-308, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30458059
9.
Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.
J Neurosci
; 37(6): 1413-1427, 2017 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28011744
10.
ALS mouse model SOD1G93A displays early pathology of sensory small fibers associated to accumulation of a neurotoxic splice variant of peripherin.
Hum Mol Genet
; 25(8): 1588-99, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26908600
11.
RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue.
J Neuroinflammation
; 15(1): 65, 2018 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29495962
12.
Presymptomatically applied AMPA receptor antagonist prevents calcium increase in vulnerable type of motor axon terminals of mice modeling amyotrophic lateral sclerosis.
Biochim Biophys Acta Mol Basis Dis
; 1863(7): 1739-1748, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28528135
13.
Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFα.
Mediators Inflamm
; 2017: 2985051, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29081600
14.
The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis.
Int J Mol Sci
; 18(11)2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29104236
15.
Immune response in peripheral axons delays disease progression in SOD1G93A mice.
J Neuroinflammation
; 13(1): 261, 2016 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27717377
16.
NG2, a common denominator for neuroinflammation, blood-brain barrier alteration, and oligodendrocyte precursor response in EAE, plays a role in dendritic cell activation.
Acta Neuropathol
; 132(1): 23-42, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27026411
17.
Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model.
Pharmacol Res
; 103: 180-7, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26640075
18.
Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
Brain
; 138(Pt 4): 974-91, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25678563
19.
Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression.
J Neurochem
; 135(1): 109-24, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25940956
20.
Human SOD1-G93A specific distribution evidenced in murine brain of a transgenic model for amyotrophic lateral sclerosis by MALDI imaging mass spectrometry.
J Proteome Res
; 13(4): 1800-9, 2014 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24579824